ABCA4 and CNGB1

Number of citations of the paper that reports this interaction (PubMedID 10466724)
0

Data Source:
HPRD (in vivo)

		ABCA4	CNGB1
Description		ATP binding cassette subfamily A member 4	cyclic nucleotide gated channel subunit beta 1
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GO Annotations	Cellular Component	Photoreceptor Outer Segment Endoplasmic Reticulum Plasma Membrane Membrane Cytoplasmic Vesicle Cell Projection Intracellular Membrane-bounded Organelle Photoreceptor Disc Membrane Rod Photoreceptor Disc Membrane	Photoreceptor Outer Segment Plasma Membrane Membrane Intracellular Cyclic Nucleotide Activated Cation Channel Complex Golgi-associated Vesicle Membrane Cell Projection Terminal Bouton Ciliary Membrane Non-motile Cilium Membrane Rod Photoreceptor Outer Segment Transmembrane Transporter Complex
	Molecular Function	Nucleotide Binding GTPase Activity Retinoid Binding 11-cis Retinal Binding All-trans Retinal Binding ATP Binding Phospholipid Transporter Activity Hydrolase Activity ATP Hydrolysis Activity Retinol Transmembrane Transporter Activity ATPase-coupled Transmembrane Transporter Activity Phosphatidylethanolamine Flippase Activity ATPase-coupled Intramembrane Lipid Transporter Activity Flippase Activity N-retinylidene-phosphatidylethanolamine Flippase Activity ABC-type Transporter Activity	Nucleotide Binding Intracellularly Cyclic Nucleotide-activated Monoatomic Cation Channel Activity Intracellularly CAMP-activated Cation Channel Activity Intracellularly CGMP-activated Cation Channel Activity Calcium Channel Activity Sodium Channel Activity Protein Binding Ligand-gated Monoatomic Ion Channel Activity CAMP Binding CGMP Binding Cyclic Nucleotide-activated Monoatomic Ion Channel Activity Protein-containing Complex Binding
	Biological Process	Retinoid Metabolic Process Phospholipid Transfer To Membrane Lipid Transport Visual Perception Phototransduction, Visible Light Organic Hydroxy Compound Transport Retinol Transport Retinal Metabolic Process Phospholipid Translocation Photoreceptor Cell Maintenance Transmembrane Transport	Retina Homeostasis Monoatomic Ion Transport Monoatomic Cation Transport Potassium Ion Transport Sodium Ion Transport Calcium Ion Transport G Protein-coupled Receptor Signaling Pathway Visual Perception Phototransduction Sensory Perception Of Smell Positive Regulation Of Gene Expression Olfactory Nerve Maturation Protein Localization To Organelle Monoatomic Ion Transmembrane Transport Sodium Ion Transmembrane Transport Photoreceptor Cell Outer Segment Organization Photoreceptor Cell Maintenance Detection Of Light Stimulus Involved In Visual Perception Detection Of Chemical Stimulus Involved In Sensory Perception Of Smell Regulation Of Cytosolic Calcium Ion Concentration Membrane Depolarization Calcium Ion Transmembrane Transport Monoatomic Cation Transmembrane Transport Response To Odorant
Pathways		The canonical retinoid cycle in rods (twilight vision) The canonical retinoid cycle in rods (twilight vision) ABC-family proteins mediated transport Defective visual phototransduction due to ABCA4 loss of function	Activation of the phototransduction cascade Inactivation, recovery and regulation of the phototransduction cascade VxPx cargo-targeting to cilium VxPx cargo-targeting to cilium
Drugs
Diseases		Macular degeneration, including: Age-related macular degeneration (ARMD); Patterned dystrophy of retinal pigment epithelium (PDREP); Retinal macular dystrophy 2 (MCDR2); X-linked atrophic macular degeneration (MDXLA) Stargardt disease (STGD); Fundus flavimaculatus Retinitis pigmentosa (RP) Cone-rod dystrophy and cone dystrophy, including: Cone-rod dystrophy (CORD); Cone dystrophy (COD); Retinal cone dystrophy (RCD)	Retinitis pigmentosa (RP)
GWAS		D-dimer levels ( 21502573) Dialysis-related mortality ( 21546767) Nonsyndromic cleft lip with cleft palate ( 28232668) Palmitoleic acid (16:1n-7) levels ( 23362303) Refractive error ( 32231278)	Initial alcohol sensitivity ( 30276832) Low density lipoprotein cholesterol levels ( 32154731) Prudent dietary pattern ( 28644415) Sensory peripheral neuropathy in microtubule targeting agent-treated breast cancer ( 32562552) Triglyceride levels ( 32154731)
Interacting Genes		2 interacting genes: ATP1A3 CNGB1	3 interacting genes: ABCA4 PNN PRPH2
Entrez ID		24	1258
HPRD ID		03408	07204
Ensembl ID		ENSG00000198691	ENSG00000070729
Uniprot IDs		P78363	Q14028
PDB IDs		7E7I 7E7O 7E7Q 7LKP 7LKZ 7M1P 7M1Q 8F5B	7RH9 7RHG 7RHH 7RHI 7RHJ 7RHK 7RHL 8DGH 8DGK
Enriched GO Terms of Interacting Partners?		Sodium Ion Transmembrane Transport Sodium Ion Transport Potassium Ion Transport Cyclic Nucleotide-activated Monoatomic Ion Channel Activity Olfactory Nerve Maturation Non-motile Cilium Membrane P-type Sodium:potassium-exchanging Transporter Activity Response To Glycoside Monoatomic Ion Homeostasis Photoreceptor Inner Segment Membrane Intracellular Monoatomic Ion Homeostasis Monoatomic Cation Homeostasis Regulation Of Membrane Potential Steroid Hormone Binding Intracellular Monoatomic Cation Homeostasis Inorganic Ion Homeostasis P-type Potassium Transmembrane Transporter Activity Nerve Maturation Response To Odorant Intracellularly CGMP-activated Cation Channel Activity Intracellular Cyclic Nucleotide Activated Cation Channel Complex Intracellularly Cyclic Nucleotide-activated Monoatomic Cation Channel Activity Intracellular Chemical Homeostasis Neuron To Neuron Synapse Intracellularly CAMP-activated Cation Channel Activity Rod Photoreceptor Outer Segment Establishment Or Maintenance Of Transmembrane Electrochemical Gradient Sodium:potassium-exchanging ATPase Complex Monoatomic Cation Transmembrane Transport Metal Ion Transport Inorganic Cation Transmembrane Transport Cellular Homeostasis Regulation Of Resting Membrane Potential Neuron Projection Maintenance Inorganic Ion Transmembrane Transport Transmembrane Transporter Complex Photoreceptor Cell Outer Segment Organization Golgi-associated Vesicle Membrane Sodium Ion Export Across Plasma Membrane CGMP Binding Monoatomic Cation Transport Monoatomic Ion Transmembrane Transport Cell Communication By Electrical Coupling Involved In Cardiac Conduction Intracellular Potassium Ion Homeostasis Retina Homeostasis Cell Communication By Electrical Coupling Cell Communication Involved In Cardiac Conduction Intracellular Sodium Ion Homeostasis Chemical Homeostasis CAMP Binding	N-retinylidene-phosphatidylethanolamine Flippase Activity Rod Photoreceptor Disc Membrane Flippase Activity Detection Of Light Stimulus Detection Of Abiotic Stimulus Photoreceptor Outer Segment Response To Low Light Intensity Stimulus Retinol Transmembrane Transporter Activity Visual Perception Phosphatidylethanolamine Flippase Activity Sensory Perception Of Light Stimulus Phospholipid Transfer To Membrane Retinol Transport Detection Of Stimulus All-trans Retinal Binding Terpenoid Transport 11-cis Retinal Binding Response To Light Stimulus Retinoid Binding Response To Radiation ATPase-coupled Intramembrane Lipid Transporter Activity Sensory Perception Phototransduction, Visible Light Photoreceptor Cell Outer Segment Organization Response To Light Intensity Phospholipid Transporter Activity Retinal Metabolic Process Photoreceptor Disc Membrane Exon-exon Junction Complex Detection Of Light Stimulus Involved In Visual Perception Detection Of Visible Light Protein Heterooligomerization Desmosome ATPase-coupled Transmembrane Transporter Activity Phospholipid Translocation Photoreceptor Cell Maintenance ABC-type Transporter Activity Phototransduction Lipid Translocation Cell Adhesion Nervous System Process Regulation Of Membrane Lipid Distribution Photoreceptor Inner Segment Aldehyde Metabolic Process Retinoid Metabolic Process Diterpenoid Metabolic Process Retina Development In Camera-type Eye Phospholipid Transport Cell Projection Catalytic Step 2 Spliceosome
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