SGK3 and NHERF2

Number of citations of the paper that reports this interaction (PubMedID 11751930)
0

Data Source:
HPRD (in vitro)

		SGK3	NHERF2
Description		serum/glucocorticoid regulated kinase family member 3	NHERF family PDZ scaffold protein 2
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GO Annotations	Cellular Component	Cytoplasm Endosome Early Endosome Cytosol Cytoplasmic Vesicle Recycling Endosome	Nucleus Plasma Membrane Focal Adhesion Endomembrane System Membrane Apical Plasma Membrane Extracellular Exosome
	Molecular Function	Nucleotide Binding Protein Kinase Activity Protein Serine/threonine Kinase Activity Calcium Channel Regulator Activity Protein Binding ATP Binding Potassium Channel Regulator Activity Kinase Activity Transferase Activity Sodium Channel Regulator Activity Chloride Channel Regulator Activity Phosphatidylinositol Binding Protein Serine Kinase Activity	Signaling Receptor Binding Protein Binding Beta-catenin Binding Phosphatase Binding Type 2 Metabotropic Glutamate Receptor Binding Type 3 Metabotropic Glutamate Receptor Binding Identical Protein Binding Protein-membrane Adaptor Activity Cadherin Binding Molecular Adaptor Activity
	Biological Process	Regulation Of Cell Growth Protein Phosphorylation Regulation Of Cell Migration Intracellular Signal Transduction Regulation Of Cell Population Proliferation Regulation Of DNA-binding Transcription Factor Activity Negative Regulation Of Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand	Protein-containing Complex Assembly Protein Localization To Plasma Membrane
Pathways		Stimuli-sensing channels
Drugs		Fostamatinib
Diseases
GWAS		Electrocardiogram morphology (amplitude at temporal datapoints) ( 32916098)
Interacting Genes		8 interacting genes: APP GSK3A GSK3B ITCH LYN NHERF2 PDPK1 SMCO1	47 interacting genes: ABCC4 ACE2 ACTN4 ACVR2B ADORA2B ADRB2 ATP2B2 BRSK2 CFTR DLGAP4 EZR IFT140 KCNJ1 LPAR1 LPAR2 P2RY1 PDGFRB PDPK1 PDZK1 PLCB3 PODXL PRKACA PRKCA PTEN PTH1R RDX RPS6KA1 SGK1 SGK3 SIAH1 SLC13A1 SLC22A4 SLC22A5 SLC22A9 SLC26A3 SLC34A1 SLC9A3 SLCO1A2 SLCO3A1 SRY TAFAZZIN TBC1D10A TCF7 TRAF4 UBC WWP2 WWTR1
Entrez ID		23678	9351
HPRD ID		06349	05946
Ensembl ID		ENSG00000104205	ENSG00000065054
Uniprot IDs		Q53EW6 Q96BR1	H3BQS0 Q15599
PDB IDs		6EDX	2D11 2HE4 2OCS 4P0C
Enriched GO Terms of Interacting Partners?		Positive Regulation Of Amyloid Precursor Protein Catabolic Process Negative Regulation Of Type B Pancreatic Cell Development Negative Regulation Of Glycogen (starch) Synthase Activity Regulation Of Amyloid Precursor Protein Catabolic Process Positive Regulation Of Protein Catabolic Process Regulation Of Glycogen (starch) Synthase Activity Beta-arrestin-dependent Dopamine Receptor Signaling Pathway Positive Regulation Of Neuron Apoptotic Process Cellular Response To Interleukin-3 C-X-C Chemokine Receptor CXCR4 Signaling Pathway Signaling Receptor Activator Activity Regulation Of Type B Pancreatic Cell Development Insulin Receptor Signaling Pathway Negative Regulation Of Glycogen Biosynthetic Process Positive Regulation Of Mitochondrial Outer Membrane Permeabilization Involved In Apoptotic Signaling Pathway Negative Regulation Of Signal Transduction Regulation Of Apoptotic Process Negative Regulation Of Signaling Regulation Of Programmed Cell Death Negative Regulation Of Cell Communication Regulation Of Cell Adhesion Positive Regulation Of Protein Metabolic Process Beta-catenin Destruction Complex Regulation Of Protein Catabolic Process Cellular Response To Oxygen-containing Compound Extrinsic Apoptotic Signaling Pathway Protein Kinase A Catalytic Subunit Binding Signaling Receptor Binding Protein Autophosphorylation Regulation Of Protein Localization Regulation Of Generation Of Precursor Metabolites And Energy Negative Regulation Of Canonical Wnt Signaling Pathway Regulation Of Innate Immune Response Positive Regulation Of Protein Localization Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Tolerance Induction Regulation Of Calcium Ion Transmembrane Transport Tau-protein Kinase Activity Negative Regulation Of Catalytic Activity Positive Regulation Of Cell Adhesion Protein Kinase Activity Response To Insulin Negative Regulation Of Wnt Signaling Pathway Regulation Of Mitochondrial Outer Membrane Permeabilization Involved In Apoptotic Signaling Pathway Cell Surface Receptor Signaling Pathway Regulation Of Intracellular Signal Transduction Positive Regulation Of Apoptotic Process Positive Regulation Of Catabolic Process Positive Regulation Of Programmed Cell Death Ephrin Receptor Binding	Apical Plasma Membrane PDZ Domain Binding Plasma Membrane Monoatomic Ion Transport Regulation Of Transport Brush Border Membrane Basolateral Plasma Membrane Regulation Of Cell Communication Regulation Of Signaling Sodium Ion Transport Regulation Of Biological Quality Membrane Regulation Of Monoatomic Ion Transport Transmembrane Transport Regulation Of Signal Transduction Positive Regulation Of Transport Adenylate Cyclase-activating G Protein-coupled Receptor Signaling Pathway Adenylate Cyclase-modulating G Protein-coupled Receptor Signaling Pathway ATP Binding Regulation Of Intracellular Signal Transduction Chloride Channel Regulator Activity Carnitine Transmembrane Transport Carnitine Transport System Process Protein Serine/threonine/tyrosine Kinase Activity Positive Regulation Of Intracellular Signal Transduction Sodium-independent Organic Anion Transport Sodium-independent Organic Anion Transmembrane Transporter Activity Circulatory System Process Amino-acid Betaine Transport Metal Ion Transport Organic Cation Transport Organic Anion Transport Protein Phosphorylation Quaternary Ammonium Group Transport Xenobiotic Transport Carboxylic Acid Transport Organic Acid Transport Nucleotide Binding Protein Kinase Activity Vascular Process In Circulatory System Phosphorylation Regulation Of MAPK Cascade Positive Regulation Of Cell Communication Positive Regulation Of Signaling Intracellular Chemical Homeostasis Protein Serine/threonine Kinase Activity Intracellular Monoatomic Cation Homeostasis Positive Regulation Of Signal Transduction Intracellular Monoatomic Ion Homeostasis
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