POLA2 and PRPF38A

Number of citations of the paper that reports this interaction (PubMedID 16169070)
0

Data Source:
BioGRID (two hybrid)
HPRD (two hybrid)

		POLA2	PRPF38A
Description		DNA polymerase alpha 2, accessory subunit	pre-mRNA processing factor 38A
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GO Annotations	Cellular Component	Nucleus Nucleoplasm Alpha DNA Polymerase:primase Complex Cytosol Ciliary Basal Body	Nucleus Nucleoplasm Spliceosomal Complex U2-type Precatalytic Spliceosome Precatalytic Spliceosome
	Molecular Function	DNA Binding Protein Binding	RNA Binding Protein Binding
	Biological Process	DNA Replication DNA Replication, Synthesis Of Primer DNA Replication Initiation Protein Import Into Nucleus	MRNA Splicing, Via Spliceosome MRNA Processing RNA Splicing
Pathways		Inhibition of replication initiation of damaged DNA by RB1/E2F1 Polymerase switching on the C-strand of the telomere Telomere C-strand synthesis initiation DNA replication initiation Activation of the pre-replicative complex Polymerase switching Removal of the Flap Intermediate Processive synthesis on the lagging strand Defective pyroptosis	mRNA Splicing - Major Pathway
Drugs		Dacarbazine
Diseases
GWAS		Acne (severe) ( 24927181) Appendicular lean mass ( 33097823) Hip circumference adjusted for BMI ( 34021172) Serum uric acid levels ( 32514006)
Interacting Genes		41 interacting genes: AGO2 AKTIP APP ARL2 ASCC2 ATL3 ATP5F1C CATSPERZ CPE CRELD1 DCP2 DDX24 DHX34 EIF6 EZH2 FAM219A FGFR3 FRZB HDAC6 HELB HGH1 IGFBP3 KCNE3 KDM2A KLF6 LRPAP1 MFHAS1 NR4A1 PARP1 POLA1 PRIM2 PRPF38A RBM23 SAC3D1 SETDB1 SNU13 STK40 TMEM216 ULK2 XPNPEP1 ZNRD2	29 interacting genes: AP2M1 APP CHERP CLK1 CLK2 CSNK2A1 DHX8 DVL3 GTF3C1 JMJD6 LUC7L2 MAPK6 POLA2 PPIG PRMT5 RBM39 RDX RNPS1 SDCBP SDCBP2 SRPK1 SRPK2 SRRM4 SRSF4 SRSF7 SRSF8 U2AF1 UBC ZCCHC10
Entrez ID		23649	84950
HPRD ID		10160	10972
Ensembl ID		ENSG00000014138	ENSG00000134748
Uniprot IDs		A0A9L9PY44 H0YDR7 Q14181	Q8NAV1
PDB IDs		2KEB 4E2I 4Y97 5EXR 7OPL 7U5C 8B9D 8D0B 8D0K 8D9D 8QJ7 8VY3 9C8V	4RZ9 4RZA 5F5S 5O9Z 6AHD 7AAV 7ABF 7ABG 7ABI 8H6K 8Q7N 8QO9 8QPE 8QZS
Enriched GO Terms of Interacting Partners?		DNA Replication, Synthesis Of Primer Regulation Of Phosphorus Metabolic Process Nucleic Acid Metabolic Process Collateral Sprouting RNA Metabolic Process Nucleobase-containing Compound Metabolic Process Regulation Of ATP Metabolic Process Regulation Of Purine Nucleotide Metabolic Process Macromolecule Metabolic Process Alpha DNA Polymerase:primase Complex Regulation Of Glycolytic Process	Regulation Of RNA Splicing Regulation Of MRNA Splicing, Via Spliceosome Regulation Of MRNA Processing RNA Splicing Nuclear Speck MRNA Processing Regulation Of MRNA Metabolic Process MRNA Metabolic Process RNA Binding RNA Processing RNA Metabolic Process Nucleoplasm Regulation Of Alternative MRNA Splicing, Via Spliceosome Nucleic Acid Metabolic Process Nucleic Acid Binding Nucleus Nucleobase-containing Compound Metabolic Process Negative Regulation Of MRNA Splicing, Via Spliceosome Negative Regulation Of RNA Splicing Protein Serine Kinase Activity Frizzled Binding Macromolecule Metabolic Process RS Domain Binding Protein Serine/threonine Kinase Activity MRNA Binding Protein Kinase Activity Protein Heterodimerization Activity Regulation Of Receptor Internalization Protein-RNA Complex Assembly Regulation Of Gene Expression RNA Splicing, Via Transesterification Reactions Kinase Activity Regulation Of Macromolecule Biosynthetic Process Regulation Of RNA Metabolic Process Regulation Of Primary Metabolic Process Positive Regulation Of JNK Cascade Negative Regulation Of MRNA Metabolic Process Low-density Lipoprotein Particle Receptor Binding Protein Binding Positive Regulation Of Receptor Internalization Protein Serine/threonine/tyrosine Kinase Activity Neuron Maturation Regulation Of Receptor-mediated Endocytosis Positive Regulation Of Viral Genome Replication Amyloid-beta Complex Growth Cone Lamellipodium Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Response To Calcium Ion Amylin Binding Positive Regulation Of Toll Signaling Pathway
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