RBFOX2 and MYO1C

Number of citations of the paper that reports this interaction (PubMedID 34133714)
84

Data Source:
BioGRID (two hybrid)

		RBFOX2	MYO1C
Description		RNA binding fox-1 homolog 2	myosin IC
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GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm	Stress Fiber Nucleus Nucleoplasm Nucleolus Cytoplasm Cytosol Actin Filament Plasma Membrane Microvillus Brush Border Cell Cortex Basal Plasma Membrane Actin Cytoskeleton Membrane Lateral Plasma Membrane Myosin Complex Unconventional Myosin Complex Nuclear Body Cytoplasmic Vesicle Membrane Cytoplasmic Vesicle Filamentous Actin Stereocilium Ruffle Membrane Cell Projection Membrane Raft Phagocytic Vesicle Stereocilium Membrane Extracellular Exosome B-WICH Complex Plasma Membrane Bounded Cell Projection
	Molecular Function	Nucleic Acid Binding Transcription Corepressor Activity RNA Binding MRNA Binding Protein Binding DNA-binding Transcription Factor Binding	Microfilament Motor Activity Nucleotide Binding Cytoskeletal Motor Activity Actin Binding Signaling Receptor Binding Protein Binding Calmodulin Binding ATP Binding Small GTPase Binding Actin Filament Binding
	Biological Process	Regulation Of Alternative MRNA Splicing, Via Spliceosome MRNA Processing Nervous System Development RNA Splicing RNA Metabolic Process Estrogen Receptor Signaling Pathway Regulation Of Cell Population Proliferation Regulation Of RNA Splicing Negative Regulation Of DNA-templated Transcription	Chromatin Remodeling Protein Targeting To Membrane Endocytosis Actin Filament Organization Actin Filament-based Movement Vesicle Transport Along Actin Filament Positive Regulation Of Cell Migration Vascular Endothelial Growth Factor Signaling Pathway Positive Regulation Of Transcription By RNA Polymerase I Positive Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Transcription By RNA Polymerase III Cellular Response To Type II Interferon Positive Regulation Of Protein Targeting To Membrane Positive Regulation Of Cellular Response To Insulin Stimulus Regulation Of Bicellular Tight Junction Assembly
Pathways		FGFR2 alternative splicing	Translocation of SLC2A4 (GLUT4) to the plasma membrane Regulation of actin dynamics for phagocytic cup formation Sensory processing of sound by inner hair cells of the cochlea Sensory processing of sound by outer hair cells of the cochlea FCGR3A-mediated phagocytosis
Drugs
Diseases
GWAS		Body size at age 10 ( 32376654) Mean corpuscular hemoglobin ( 32888494) Mean corpuscular volume ( 32888494) Reading disability or specific language impairment (pleiotropy) ( 25065397) Red cell distribution width ( 32888494) Waist-to-hip ratio adjusted for BMI (age >50) ( 26426971) Waist-to-hip ratio adjusted for BMI x sex x age interaction (4df test) ( 26426971)	Appendicular lean mass ( 33097823) Atrial fibrillation ( 30061737) Mean platelet volume ( 32888494) Neutrophil count ( 32888494) Pulse pressure ( 30578418) White blood cell count ( 32888494)
Interacting Genes		183 interacting genes: ADARB1 ALG13 ANKHD1 APH1A ATN1 ATXN1 ATXN1L BAG4 BOLL C1orf94 CALD1 CAMK2A CAMK2B CHAF1A CHERP CLASP2 CPSF7 DAB1 DAZAP2 DDX21 DDX5 DEDD2 DENND1B DMRTB1 DNAH5 EIF4ENIF1 ELAVL1 ELAVL2 ESR1 ESR2 FAM168B FBXO7 FSAF1 GIMAP4 GLIS2 GTF2A1L H1-4 HMGA1 HNRNPAB HNRNPF HNRNPH1 HNRNPH2 HNRNPK KHDRBS1 KHDRBS2 KIF20A KRT31 KRTAP6-2 LMNA LSM5 MAGED1 MAPK1IP1L MBNL1 MED7 MIR1-1 MIR106A MIR107 MIR10B MIR122 MIR128-1 MIR128-2 MIR138-2 MIR140 MIR141 MIR143 MIR155 MIR15B MIR16-1 MIR16-2 MIR17 MIR18A MIR18B MIR199A1 MIR199A2 MIR19A MIR19B1 MIR19B2 MIR200A MIR200B MIR200C MIR205 MIR206 MIR20B MIR21 MIR214 MIR221 MIR222 MIR25 MIR29A MIR29B1 MIR29C MIR31 MIR34A MIR34B MIR34C MIR363 MIR429 MIR451A MIR7-1 MIR9-1 MIR9-2 MIR9-3 MIR93 MIRLET7A1 MIRLET7A3 MIRLET7B MIRLET7C MIRLET7E MIRLET7F1 MIRLET7F2 MIRLET7G MIRLET7I MRPL4 MSI2 MTG1 MYO1C NAF1 NLGN3 NOL8 NR2E3 NXF1 OGT OXER1 PA2G4 PCBP1 PCBP2 PCNP PDIA3 PEG10 POLR3D PPIL4 PRMT5 PRPF19 PRPF38B PRRC2B PSMA3 PSMF1 PTBP1 PURB QARS1 QKI RBFOX1 RBFOX3 RBM12 RBM17 RBM22 RBM23 RBM42 RBPMS RBPMS2 RERE RHOXF2 RNF8 RPL3 RPL4 RPN1 RPS13 RPS28 SDHC SF1 SF3A1 SF3B3 SF3B4 SMN1 SNRPA SNRPC SNW1 SPATS2L SPMIP9 SPOP SRP68 ST13 SUPV3L1 SURF6 TNRC6A TOLLIP U2AF2 UBQLN2 VAC14 YTHDF1 YTHDF3 ZC3H10 ZNF137P	12 interacting genes: BAZ1B CBL CDC42 KHDRBS1 MYH10 NEIL3 PTEN RBFOX2 RBPMS RRN3 SEPTIN9 WEE2-AS1
Entrez ID		23543	4641
HPRD ID		15231	09411
Ensembl ID		ENSG00000100320	ENSG00000197879
Uniprot IDs		A0A8Q3WKT3 O43251	F5H6E2 O00159
PDB IDs		2CQ3	4BYF
Enriched GO Terms of Interacting Partners?		MiRNA-mediated Post-transcriptional Gene Silencing Regulatory NcRNA-mediated Post-transcriptional Gene Silencing Post-transcriptional Gene Silencing MRNA Base-pairing Post-transcriptional Repressor Activity RISC Complex Regulatory NcRNA-mediated Gene Silencing Post-transcriptional Regulation Of Gene Expression MRNA 3'-UTR Binding Negative Regulation Of Gene Expression Negative Regulation Of Macromolecule Metabolic Process Negative Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of Biosynthetic Process MiRNA-mediated Gene Silencing By Inhibition Of Translation Regulation Of MRNA Metabolic Process Negative Regulation Of Metabolic Process Regulation Of Gene Expression Regulation Of Macromolecule Biosynthetic Process MiRNA-mediated Gene Silencing By MRNA Destabilization Regulation Of Macromolecule Metabolic Process Positive Regulation Of MRNA Metabolic Process RNA Binding Extracellular Vesicle Positive Regulation Of MRNA Catabolic Process Regulation Of Metabolic Process MRNA Destabilization RNA Destabilization Negative Regulation Of Translation Nucleic Acid Binding Regulation Of Translation Regulation Of RNA Stability Regulation Of MRNA Stability Regulation Of RNA Splicing MRNA Binding Negative Regulation Of Vascular Endothelial Growth Factor Production Negative Regulation Of Cell Migration Negative Regulation Of Cell Motility Negative Regulation Of Locomotion Regulation Of Primary Metabolic Process Negative Regulation Of Cytokine Production Negative Regulation Of Angiogenesis Negative Regulation Of Vasculature Development Negative Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Negative Regulation Of Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway MRNA Processing Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Negative Regulation Of Protein Metabolic Process RNA Processing Regulation Of Blood Vessel Endothelial Cell Migration Regulation Of Angiogenesis Regulation Of Vasculature Development	Regulation Of Alternative MRNA Splicing, Via Spliceosome Dendritic Spine Morphogenesis Regulation Of MRNA Splicing, Via Spliceosome Regulation Of MRNA Processing Nucleus Localization Dendritic Spine Organization Nuclear Migration Molecular Function Inhibitor Activity Regulation Of RNA Splicing Protein Tyrosine Kinase Binding Neuron Projection Organization Postsynapse Organization Nucleic Acid Binding Establishment Of Organelle Localization Neuron Projection Morphogenesis Negative Regulation Of Synaptic Vesicle Clustering Histone H2AXY142 Kinase Activity Grb2-Sos Complex MRNA Binding MCM Complex Binding Cell Projection Morphogenesis Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction GBD Domain Binding Storage Vacuole Fourth Ventricle Development Phosphatidylinositol-3,4-bisphosphate 3-phosphatase Activity Negative Regulation Of Keratinocyte Migration Inositol-1,3,4,5-tetrakisphosphate 3-phosphatase Activity Inositol-1,3,4,5,6-pentakisphosphate 3-phosphatase Activity WICH Complex Negative Regulation Of Mitotic Chromosome Condensation Regulation Of MRNA Metabolic Process Neuron Projection Stress Fiber Positive Regulation Of Transport Endothelin Receptor Signaling Pathway Involved In Heart Process Actin Cytoskeleton Organization Cytoskeleton-dependent Cytokinesis Myosin II Filament Central Nervous System Myelin Maintenance Rhythmic Synaptic Transmission RNA Polymerase I Core Binding SH3 Domain Binding Regulation Of Rap Protein Signal Transduction Actin Filament-based Process Apolipoprotein A-I Receptor Binding Neuropilin Signaling Pathway Cytoplasmic Side Of Plasma Membrane Negative Regulation Of Wound Healing, Spreading Of Epidermal Cells Negative Regulation Of Chromosome Condensation
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