FOSB and CYTH4

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		FOSB	CYTH4
Description		FosB proto-oncogene, AP-1 transcription factor subunit	cytohesin 4
Image			No pdb structure
GO Annotations	Cellular Component	Chromatin Nucleus Nucleoplasm Cytosol	Golgi Membrane Cytosol Plasma Membrane Membrane Centriolar Satellite Intercellular Bridge
	Molecular Function	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Activator Activity, RNA Polymerase II-specific DNA Binding Double-stranded DNA Binding DNA-binding Transcription Factor Activity Protein Binding Sequence-specific DNA Binding Sequence-specific Double-stranded DNA Binding	Guanyl-nucleotide Exchange Factor Activity Protein Binding Lipid Binding
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Response To Amphetamine Regulation Of DNA-templated Transcription Regulation Of Transcription By RNA Polymerase II Transcription By RNA Polymerase II Female Pregnancy Response To Xenobiotic Stimulus Response To Mechanical Stimulus Response To Progesterone Cellular Response To Hormone Stimulus Response To Nicotine Response To Cocaine Response To Morphine Response To Ethanol Positive Regulation Of Transcription By RNA Polymerase II Behavioral Response To Cocaine Response To Corticosterone Response To CAMP Cellular Response To Calcium Ion	Regulation Of ARF Protein Signal Transduction
Pathways		Estrogen-dependent gene expression NGF-stimulated transcription NGF-stimulated transcription Regulation of PD-L1(CD274) transcription	Intra-Golgi traffic
Drugs
Diseases
GWAS		Alzheimer's disease or HDL levels (pleiotropy) ( 30805717) Heel bone mineral density ( 28869591 30598549)	Response to methotrexate in juvenile idiopathic arthritis ( 24709693) Uterine fibroids ( 28836065)
Interacting Genes		28 interacting genes: AGXT CENPO CREB5 CYTH4 DNMT3L ENKD1 EP300 FAM222B FAM90A1 FOXP3 GLIS2 JUNB JUND LINC00963 NCK2 NEDD9 NFE2L2 PHC2 PHF1 POGZ POU6F2 ROR2 SRA1 TENT5B TLE5 TLX3 VEZF1 ZC3H10	24 interacting genes: AMOTL2 AP1B1 CBY2 CCDC197 CCDC6 CNKSR1 CTAG1A CTAG1B FOS FOSB HOOK2 KANK2 KIFC3 KRT15 KRT16 KRT34 KRT40 PCM1 PSMB1 SNAPC5 SNCA SYCE1L TRIM54 USHBP1
Entrez ID		2354	27128
HPRD ID		01270	07354
Ensembl ID		ENSG00000125740	ENSG00000100055
Uniprot IDs		P53539	B4E2V8 Q9UIA0
PDB IDs		5VPA 5VPB 5VPC 5VPD 5VPE 5VPF 6UCI 6UCL 6UCM 7UCC 7UCD
Enriched GO Terms of Interacting Partners?		Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of DNA-templated Transcription Regulation Of RNA Metabolic Process Regulation Of RNA Biosynthetic Process Regulation Of Gene Expression Regulation Of Transcription By RNA Polymerase II DNA Binding Regulation Of Macromolecule Biosynthetic Process Regulation Of T-helper 17 Cell Differentiation Positive Regulation Of Macromolecule Biosynthetic Process Regulation Of Macromolecule Metabolic Process Regulation Of Primary Metabolic Process Positive Regulation Of Biosynthetic Process Positive Regulation Of Macromolecule Metabolic Process Positive Regulation Of RNA Biosynthetic Process Chromatin Regulation Of T-helper 17 Type Immune Response Positive Regulation Of DNA-templated Transcription DNA-binding Transcription Factor Activity, RNA Polymerase II-specific Transcription Factor AP-1 Complex Transcription Coregulator Binding Protein-DNA Complex DNA-binding Transcription Activator Activity, RNA Polymerase II-specific Positive Regulation Of RNA Metabolic Process Regulation Of T-helper Cell Differentiation DNA-binding Transcription Factor Activity Regulation Of Metabolic Process Positive Regulation Of Metabolic Process Positive Regulation Of Transcription By RNA Polymerase II Regulation Of CD4-positive, Alpha-beta T Cell Differentiation Positive Regulation Of Nucleobase-containing Compound Metabolic Process Nucleus Negative Regulation Of RNA Metabolic Process ESC/E(Z) Complex Sequence-specific Double-stranded DNA Binding Regulation Of CD4-positive, Alpha-beta T Cell Activation Nucleoplasm Negative Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Cell Activation CD4-positive, Alpha-beta T Cell Lineage Commitment Regulation Of Cell Differentiation Zinc Ion Binding Alpha-beta T Cell Lineage Commitment CD4-positive Or CD8-positive, Alpha-beta T Cell Lineage Commitment Negative Regulation Of DNA-templated Transcription Negative Regulation Of RNA Biosynthetic Process Regulation Of Alpha-beta T Cell Activation Negative Regulation Of Macromolecule Metabolic Process L-serine-pyruvate Transaminase Activity T Cell Lineage Commitment	Structural Constituent Of Skin Epidermis Supramolecular Fiber Organization Intermediate Filament Organization Intermediate Filament Cytoskeleton Organization Keratin Filament Intermediate Filament-based Process Cytoskeleton Cytoskeleton Organization Organelle Organization Intermediate Filament Structural Molecule Activity Response To Corticosterone Behavioral Response To Cocaine TRNA Threonylcarbamoyladenosine Metabolic Process Identical Protein Binding Microtubule Binding Structural Constituent Of Cytoskeleton Response To Progesterone Response To Mineralocorticoid Medium-term Memory Cellular Response To Prolactin Epidermis Development Morphogenesis Of An Epithelium Epithelial Cell Migration Response To Desipramine Negative Regulation Of Norepinephrine Uptake Phospholipase D Inhibitor Activity Negative Regulation Of Supramolecular Fiber Organization Positive Regulation Of SNARE Complex Assembly Negative Regulation Of Cytoskeleton Organization Negative Regulation Of Dopamine Uptake Involved In Synaptic Transmission Response To Cocaine Cytoplasmic Vesicle Membrane Cellular Response To Metal Ion Negative Regulation Of Microtubule Polymerization Or Depolymerization
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