CYTH4 and AMOTL2

Number of citations of the paper that reports this interaction (PubMedID 25416956)
56

Data Source:
BioGRID (two hybrid)

		CYTH4	AMOTL2
Description		cytohesin 4	angiomotin like 2
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Golgi Membrane Cytosol Plasma Membrane Membrane Centriolar Satellite Intercellular Bridge	Podosome Cytoplasm Endosome Cytosol Plasma Membrane Bicellular Tight Junction Cell Junction Cytoplasmic Vesicle Cell Projection Recycling Endosome Anchoring Junction
	Molecular Function	Guanyl-nucleotide Exchange Factor Activity Protein Binding Lipid Binding	Protein Binding Actin Filament Binding
	Biological Process	Regulation Of ARF Protein Signal Transduction	Negative Regulation Of Transcription By RNA Polymerase II Angiogenesis Endothelial Cell Morphogenesis Establishment Of Cell Polarity Involved In Ameboidal Cell Migration Wnt Signaling Pathway Actin Cytoskeleton Organization Regulation Of Cell Migration Hippo Signaling Positive Regulation Of Protein Localization
Pathways		Intra-Golgi traffic	Signaling by Hippo
Drugs
Diseases
GWAS		Response to methotrexate in juvenile idiopathic arthritis ( 24709693) Uterine fibroids ( 28836065)	Cadmium levels ( 26025379) High light scatter reticulocyte count ( 32888494) High light scatter reticulocyte percentage of red cells ( 32888494) Reticulocyte fraction of red cells ( 32888494) Spherical equivalent or myopia (age of diagnosis) ( 29808027) Vertical cup-disc ratio (adjusted for vertical disc diameter) ( 31959993)
Interacting Genes		24 interacting genes: AMOTL2 AP1B1 CBY2 CCDC197 CCDC6 CNKSR1 CTAG1A CTAG1B FOS FOSB HOOK2 KANK2 KIFC3 KRT15 KRT16 KRT34 KRT40 PCM1 PSMB1 SNAPC5 SNCA SYCE1L TRIM54 USHBP1	93 interacting genes: AMOT BFSP2 BLZF1 BRMS1L BYSL CARD9 CCDC185 CCDC196 CCDC57 CCHCR1 CDC37 CDR2 CHCHD3 CINP CYTH4 DAXX DDIT3 DSCAM DTNB DYNLL1 DZIP1L EIF4E2 EPHB1 FAM184A FAM90A1 FBXO7 FCRL5 FXR2 GCC1 GNG11 GNG5 GOLGA2 GSTM5 KIF9 KRT1 KRT13 KRT15 KRT19 KRT20 KRT31 KRT38 KRTAP10-5 KRTAP4-2 L3MBTL2 LMNB2 LMO3 LMO4 MAD1L1 MAGEA4 MAGOHB MFAP1 MORF4L2 MPP1 MTCL2 MTMR6 MTNR1A MYO5B NDC80 NF2 NFIL3 NME7 NTAQ1 PIBF1 PPP2CA PPP2R1A PRKAA2 PRPF18 PSMC3 RAD51D RALBP1 RASAL3 RASSF5 RNF20 RNF40 RNF8 SAAL1 SH3RF2 SMARCE1 SP100 SPAG5 SPOP SPP1 TCEA2 THRA TMCC2 TNKS2 TRAF2 TRIM27 TSGA10IP YES1 ZBED1 ZBTB16 ZGPAT
Entrez ID		27128	51421
HPRD ID		07354	16485
Ensembl ID		ENSG00000100055	ENSG00000114019
Uniprot IDs		B4E2V8 Q9UIA0	Q9Y2J4
PDB IDs
Enriched GO Terms of Interacting Partners?		Structural Constituent Of Skin Epidermis Supramolecular Fiber Organization Intermediate Filament Organization Intermediate Filament Cytoskeleton Organization Keratin Filament Intermediate Filament-based Process Cytoskeleton Cytoskeleton Organization Organelle Organization Intermediate Filament Structural Molecule Activity Response To Corticosterone Behavioral Response To Cocaine TRNA Threonylcarbamoyladenosine Metabolic Process Identical Protein Binding Microtubule Binding Structural Constituent Of Cytoskeleton Response To Progesterone Response To Mineralocorticoid Medium-term Memory Cellular Response To Prolactin Epidermis Development Morphogenesis Of An Epithelium Epithelial Cell Migration Response To Desipramine Negative Regulation Of Norepinephrine Uptake Phospholipase D Inhibitor Activity Negative Regulation Of Supramolecular Fiber Organization Positive Regulation Of SNARE Complex Assembly Negative Regulation Of Cytoskeleton Organization Negative Regulation Of Dopamine Uptake Involved In Synaptic Transmission Response To Cocaine Cytoplasmic Vesicle Membrane Cellular Response To Metal Ion Negative Regulation Of Microtubule Polymerization Or Depolymerization	Keratin Filament Intermediate Filament Intermediate Filament Organization Cytoskeleton Structural Constituent Of Skin Epidermis Intermediate Filament-based Process Intermediate Filament Cytoskeleton Organization Protein Binding Identical Protein Binding Structural Constituent Of Cytoskeleton Cytoskeleton Organization Ubiquitin Protein Ligase Binding Structural Molecule Activity Nucleus Cytosol Centriolar Satellite Organelle Organization Protein Polyubiquitination Centrosome Chromosome, Centromeric Region HULC Complex PML Body Supramolecular Fiber Organization Ubiquitin Ligase Complex Protein Modification By Small Protein Conjugation Protein Modification Process Regulation Of Primary Metabolic Process Protein Ubiquitination Negative Regulation Of Nucleobase-containing Compound Metabolic Process Negative Regulation Of Metabolic Process Regulation Of Cell Cycle
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