CABIN1 and PPP3CB

Number of citations of the paper that reports this interaction (PubMedID 11714752)
52

Data Source:
HPRD (in vivo, two hybrid)

		CABIN1	PPP3CB
Description		calcineurin binding protein 1	protein phosphatase 3 catalytic subunit beta
Image
GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytosol Aggresome	Nucleoplasm Cytoplasm Cytosol Plasma Membrane Calcineurin Complex Protein Serine/threonine Phosphatase Complex Z Disc T-tubule Glutamatergic Synapse
	Molecular Function	Protein Phosphatase Inhibitor Activity Protein Binding Nucleosome Binding	Phosphoprotein Phosphatase Activity Protein Serine/threonine Phosphatase Activity Calcium Ion Binding Protein Binding Calmodulin Binding Hydrolase Activity Enzyme Binding Protein Phosphatase 2B Binding Calmodulin-dependent Protein Phosphatase Activity Metal Ion Binding Protein Dimerization Activity
	Biological Process	Chromatin Organization Nucleosome Assembly Cell Surface Receptor Signaling Pathway	T Cell Mediated Cytotoxicity Negative Regulation Of T Cell Mediated Cytotoxicity Lymphangiogenesis Protein Phosphorylation Protein Dephosphorylation Response To Stress Lysosome Organization Signal Transduction Heart Development Learning Memory Regulation Of Gene Expression Dephosphorylation Calcium-ion Regulated Exocytosis Negative Regulation Of Signaling T Cell Differentiation Locomotion Involved In Locomotory Behavior Calcineurin-NFAT Signaling Cascade Response To Cytokine Positive Regulation Of Insulin Secretion Involved In Cellular Response To Glucose Stimulus T Cell Proliferation T Cell Activation T Cell Homeostasis Negative Regulation Of Innate Immune Response Positive Regulation Of DNA-templated Transcription Positive Regulation Of Transcription By RNA Polymerase II Regulation Of Synaptic Plasticity Axon Extension Skeletal Muscle Fiber Development Regulation Of Insulin Secretion Positive Regulation Of Calcineurin-NFAT Signaling Cascade Calcineurin-mediated Signaling Antibacterial Innate Immune Response Negative Regulation Of Protein Localization To Nucleus Positive Regulation Of Protein Localization To Nucleus Regulation Of Synaptic Vesicle Endocytosis Positive Regulation Of Calcium Ion Import Across Plasma Membrane Positive Regulation Of Lysosome Organization Negative Regulation Of Calcium Ion Import Across Plasma Membrane
Pathways		Formation of Senescence-Associated Heterochromatin Foci (SAHF)	DARPP-32 events Calcineurin activates NFAT Calcineurin activates NFAT FCERI mediated Ca+2 mobilization Ca2+ pathway CLEC7A (Dectin-1) induces NFAT activation ROBO receptors bind AKAP5
Drugs
Diseases
GWAS		Acne (severe) ( 24927181) Amyotrophic lateral sclerosis ( 23624525) Coronary artery disease ( 29212778) Femur bone mineral density x serum urate levels interaction ( 34046847) Monocyte count ( 32888494) S-phenylmercapturic acid levels in smokers ( 26959369) Urinary metabolite levels in chronic kidney disease ( 31959995)
Interacting Genes		14 interacting genes: AMPH BORCS8-MEF2B CALM1 CAMK4 DNM1 GRM1 HDAC2 LCOR MEF2B MEF2D PPP3CA PPP3CB PPP3CC YWHAQ	21 interacting genes: AATK CABIN1 EGFR FBXL17 IRAK1 IRF2 JUN LMTK2 MARCHF7 MYOZ2 MYOZ3 NFATC2 PRICKLE1 PTK7 RCAN1 ROR2 RUNX1 SLC8A1 SLC8A2 SLC8A3 SOCS3
Entrez ID		23523	5532
HPRD ID		10369	00235
Ensembl ID		ENSG00000099991	ENSG00000107758
Uniprot IDs		A0A087WWW8 Q9Y6J0	B7Z781 P16298
PDB IDs		1N6J	4OR9 4ORA 4ORC
Enriched GO Terms of Interacting Partners?		Negative Regulation Of Monoatomic Ion Transmembrane Transport Calcineurin-mediated Signaling Calmodulin-dependent Protein Phosphatase Activity Negative Regulation Of Calcium Ion Import Across Plasma Membrane Calcineurin Complex Negative Regulation Of Monoatomic Ion Transport Negative Regulation Of Calcium Ion Transmembrane Transport Negative Regulation Of Transmembrane Transport Protein Serine/threonine Phosphatase Complex Histone Deacetylase Binding Positive Regulation Of Calcium Ion Import Across Plasma Membrane Negative Regulation Of Calcium Ion Transport Negative Regulation Of Calcium Ion Import Regulation Of Calcium Ion Import Across Plasma Membrane Protein Dimerization Activity Negative Regulation Of Cation Transmembrane Transport Positive Regulation Of Calcineurin-NFAT Signaling Cascade Calcineurin-NFAT Signaling Cascade Regulation Of Calcium-mediated Signaling Positive Regulation Of Calcium Ion Import Regulation Of Monoatomic Ion Transmembrane Transport Regulation Of Calcineurin-NFAT Signaling Cascade Regulation Of Calcineurin-mediated Signaling Regulation Of Calcium Ion Transmembrane Transport Regulation Of Calcium Ion Import Calcium-mediated Signaling Positive Regulation Of Calcium-mediated Signaling Regulation Of Monoatomic Ion Transport Negative Regulation Of Transport Calmodulin Binding Positive Regulation Of Calcium Ion Transmembrane Transport Regulation Of Calcium Ion Transport Protein Dephosphorylation Protein Serine/threonine Phosphatase Activity Regulation Of Monoatomic Cation Transmembrane Transport Heart Development Positive Regulation Of Calcium Ion Transport Positive Regulation Of Cation Transmembrane Transport Positive Regulation Of Monoatomic Ion Transmembrane Transport Muscle Organ Development Regulation Of Metal Ion Transport Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription Dephosphorylation Cardiac Muscle Hypertrophy Regulation Of Synaptic Vesicle Endocytosis Phosphoprotein Phosphatase Activity Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Muscle Structure Development	Calcium:sodium Antiporter Activity Eyelid Development In Camera-type Eye Striated Muscle Cell Development Calcium:monoatomic Cation Antiporter Activity Involved In Regulation Of Postsynaptic Cytosolic Calcium Ion Concentration Calcium Ion Import Across Plasma Membrane Calcium Ion Import Into Cytosol Regulation Of Cardiac Conduction Muscle Cell Development Regulation Of Signal Transduction Calcium Ion Import Regulation Of Calcineurin-mediated Signaling Calcium Ion Export Across Plasma Membrane FATZ Binding Negative Regulation Of Signal Transduction Protein Phosphatase Inhibitor Activity Transcription Factor AP-1 Complex Protein Kinase Activity Regulation Of Cell Communication Negative Regulation Of Cell Communication Regulation Of Signaling Negative Regulation Of Signaling Telethonin Binding Axon Terminus Regulation Of Postsynaptic Cytosolic Calcium Ion Concentration Export Across Plasma Membrane Neuronal Cell Body Axon Negative Regulation Of Cardiocyte Differentiation Calcium Ion Transport Into Cytosol Negative Regulation Of Calcineurin-NFAT Signaling Cascade Calcium Ion Transmembrane Import Into Cytosol Cellular Developmental Process Regulation Of Calcium-mediated Signaling Inorganic Cation Import Across Plasma Membrane Antiporter Activity Negative Regulation Of Intracellular Signal Transduction Synapse Organization Postsynaptic Density Transcription Cis-regulatory Region Binding Calcineurin-NFAT Signaling Cascade Learning Or Memory Regulation Of Intracellular Signal Transduction Negative Regulation Of Calcium-mediated Signaling Negative Regulation Of Smooth Muscle Cell Differentiation Cell Surface Receptor Signaling Pathway Sarcolemma Memory Intracellular Signaling Cassette Response To Muscle Stretch Coronary Vasculature Development
Tagcloud ?
Tagcloud (Difference) ?
Tagcloud (Intersection) ?