PPP3CB and SLC8A2

Number of citations of the paper that reports this interaction (PubMedID 15557343)
0

Data Source:
HPRD (in vivo)

		PPP3CB	SLC8A2
Description		protein phosphatase 3 catalytic subunit beta	solute carrier family 8 member A2
Image			No pdb structure
GO Annotations	Cellular Component	Nucleoplasm Cytoplasm Cytosol Plasma Membrane Calcineurin Complex Protein Serine/threonine Phosphatase Complex Z Disc T-tubule Glutamatergic Synapse	Plasma Membrane Postsynaptic Density Membrane Basolateral Plasma Membrane Axon Dendrite Sarcolemma Cell Projection Neuronal Cell Body Dendritic Spine Perikaryon Axon Terminus Synapse Presynapse Postsynapse
	Molecular Function	Phosphoprotein Phosphatase Activity Protein Serine/threonine Phosphatase Activity Calcium Ion Binding Protein Binding Calmodulin Binding Hydrolase Activity Enzyme Binding Protein Phosphatase 2B Binding Calmodulin-dependent Protein Phosphatase Activity Metal Ion Binding Protein Dimerization Activity	Calcium:sodium Antiporter Activity Calmodulin Binding Sodium Ion Transmembrane Transporter Activity Calcium Ion Transmembrane Transporter Activity Antiporter Activity Metal Ion Binding Calcium:monoatomic Cation Antiporter Activity Involved In Regulation Of Postsynaptic Cytosolic Calcium Ion Concentration
	Biological Process	T Cell Mediated Cytotoxicity Negative Regulation Of T Cell Mediated Cytotoxicity Lymphangiogenesis Protein Phosphorylation Protein Dephosphorylation Response To Stress Lysosome Organization Signal Transduction Heart Development Learning Memory Regulation Of Gene Expression Dephosphorylation Calcium-ion Regulated Exocytosis Negative Regulation Of Signaling T Cell Differentiation Locomotion Involved In Locomotory Behavior Calcineurin-NFAT Signaling Cascade Response To Cytokine Positive Regulation Of Insulin Secretion Involved In Cellular Response To Glucose Stimulus T Cell Proliferation T Cell Activation T Cell Homeostasis Negative Regulation Of Innate Immune Response Positive Regulation Of DNA-templated Transcription Positive Regulation Of Transcription By RNA Polymerase II Regulation Of Synaptic Plasticity Axon Extension Skeletal Muscle Fiber Development Regulation Of Insulin Secretion Positive Regulation Of Calcineurin-NFAT Signaling Cascade Calcineurin-mediated Signaling Antibacterial Innate Immune Response Negative Regulation Of Protein Localization To Nucleus Positive Regulation Of Protein Localization To Nucleus Regulation Of Synaptic Vesicle Endocytosis Positive Regulation Of Calcium Ion Import Across Plasma Membrane Positive Regulation Of Lysosome Organization Negative Regulation Of Calcium Ion Import Across Plasma Membrane	Response To Ischemia Monoatomic Ion Transport Sodium Ion Transport Calcium Ion Transport Intracellular Calcium Ion Homeostasis Cell Communication Learning Or Memory Learning Memory Regulation Of Gene Expression Sodium Ion Transmembrane Transport Regulation Of Short-term Neuronal Synaptic Plasticity Synapse Organization Cognition Regulation Of Cytosolic Calcium Ion Concentration Transmembrane Transport Long-term Synaptic Potentiation Neuron Cellular Homeostasis Calcium Ion Transmembrane Transport Calcium Ion Import Across Plasma Membrane Modulation Of Excitatory Postsynaptic Potential Regulation Of Postsynaptic Cytosolic Calcium Ion Concentration Regulation Of Action Potential Firing Pattern Regulation Of Calcineurin-mediated Signaling Transport Across Blood-brain Barrier Positive Regulation Of Intracellular Signal Transduction Regulation Of Cardiac Conduction Calcium Ion Export Across Plasma Membrane
Pathways		DARPP-32 events Calcineurin activates NFAT Calcineurin activates NFAT FCERI mediated Ca+2 mobilization Ca2+ pathway CLEC7A (Dectin-1) induces NFAT activation ROBO receptors bind AKAP5	Reduction of cytosolic Ca++ levels Sodium/Calcium exchangers Ion homeostasis
Drugs
Diseases
GWAS			Resting-state electroencephalogram vigilance ( 29703947)
Interacting Genes		21 interacting genes: AATK CABIN1 EGFR FBXL17 IRAK1 IRF2 JUN LMTK2 MARCHF7 MYOZ2 MYOZ3 NFATC2 PRICKLE1 PTK7 RCAN1 ROR2 RUNX1 SLC8A1 SLC8A2 SLC8A3 SOCS3	7 interacting genes: GPR35 GPR37 PPP3CB YWHAB YWHAE YWHAQ YWHAZ
Entrez ID		5532	6543
HPRD ID		00235	15990
Ensembl ID		ENSG00000107758	ENSG00000118160
Uniprot IDs		B7Z781 P16298	Q9UPR5
PDB IDs		4OR9 4ORA 4ORC
Enriched GO Terms of Interacting Partners?		Calcium:sodium Antiporter Activity Eyelid Development In Camera-type Eye Striated Muscle Cell Development Calcium:monoatomic Cation Antiporter Activity Involved In Regulation Of Postsynaptic Cytosolic Calcium Ion Concentration Calcium Ion Import Across Plasma Membrane Calcium Ion Import Into Cytosol Regulation Of Cardiac Conduction Muscle Cell Development Regulation Of Signal Transduction Calcium Ion Import Regulation Of Calcineurin-mediated Signaling Calcium Ion Export Across Plasma Membrane FATZ Binding Negative Regulation Of Signal Transduction Protein Phosphatase Inhibitor Activity Transcription Factor AP-1 Complex Protein Kinase Activity Regulation Of Cell Communication Negative Regulation Of Cell Communication Regulation Of Signaling Negative Regulation Of Signaling Telethonin Binding Axon Terminus Regulation Of Postsynaptic Cytosolic Calcium Ion Concentration Export Across Plasma Membrane Neuronal Cell Body Axon Negative Regulation Of Cardiocyte Differentiation Calcium Ion Transport Into Cytosol Negative Regulation Of Calcineurin-NFAT Signaling Cascade Calcium Ion Transmembrane Import Into Cytosol Cellular Developmental Process Regulation Of Calcium-mediated Signaling Inorganic Cation Import Across Plasma Membrane Antiporter Activity Negative Regulation Of Intracellular Signal Transduction Synapse Organization Postsynaptic Density Transcription Cis-regulatory Region Binding Calcineurin-NFAT Signaling Cascade Learning Or Memory Regulation Of Intracellular Signal Transduction Negative Regulation Of Calcium-mediated Signaling Negative Regulation Of Smooth Muscle Cell Differentiation Cell Surface Receptor Signaling Pathway Sarcolemma Memory Intracellular Signaling Cassette Response To Muscle Stretch Coronary Vasculature Development	Phosphoserine Residue Binding Negative Regulation Of Monoatomic Ion Transmembrane Transport Negative Regulation Of Monoatomic Ion Transport Negative Regulation Of Transmembrane Transport Negative Regulation Of Transport Negative Regulation Of Calcium Ion Transmembrane Transport Protein Sequestering Activity Negative Regulation Of Protein Localization To Nucleus Protein Targeting Negative Regulation Of Calcium Ion Transport Protein Domain Specific Binding Negative Regulation Of Cation Transmembrane Transport Regulation Of Monoatomic Ion Transmembrane Transport Locomotion Involved In Locomotory Behavior Melanosome Regulation Of Monoatomic Ion Transport Focal Adhesion Regulation Of Lysosome Organization Antibacterial Innate Immune Response Transmembrane Transporter Binding Regulation Of Calcium Ion Transmembrane Transport Regulation Of Protein Localization To Nucleus Signal Transduction Negative Regulation Of Protein Localization Regulation Of Calcium Ion Transport Phosphoprotein Binding Regulation Of Transport Regulation Of Monoatomic Cation Transmembrane Transport Protein Phosphatase Inhibitor Activity Substantia Nigra Development Ubiquitin Protein Ligase Binding Intracellular Signaling Cassette Cadherin Binding Regulation Of Protein Localization Regulation Of Metal Ion Transport Lysosome Organization Regulation Of Vacuole Organization Neural Nucleus Development Enzyme Binding Regulation Of Protein Transport Regulation Of Innate Immune Response Protein Phosphatase Binding Negative Regulation Of Innate Immune Response Prosaposin Receptor Activity Regulation Of Heart Rate By Hormone Synaptic Target Recognition Regulation Of Cellular Localization Establishment Of Protein Localization Regulation Of Establishment Of Protein Localization Negative Regulation Of Immune System Process
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