CBX7 and RING1

Number of citations of the paper that reports this interaction (PubMedID 14647293)
0

Data Source:
HPRD (in vitro, in vivo)

		CBX7	RING1
Description		chromobox 7	ring finger protein 1
Image			No pdb structure
GO Annotations	Cellular Component	Chromatin Nucleus Nucleoplasm Cytosol PcG Protein Complex PRC1 Complex	Ubiquitin Ligase Complex Sex Chromatin Nucleus Nucleoplasm Cytosol Nuclear Body Nuclear Speck PcG Protein Complex PRC1 Complex
	Molecular Function	Protein Binding	Chromatin Binding Protein Binding Zinc Ion Binding Transferase Activity Metal Ion Binding Ubiquitin Protein Ligase Activity Ubiquitin-protein Transferase Activator Activity
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Chromatin Organization	Chromatin Organization Chromatin Remodeling Anterior/posterior Pattern Specification Protein Ubiquitination Negative Regulation Of DNA-templated Transcription Camera-type Eye Morphogenesis
Pathways			Oxidative Stress Induced Senescence SUMOylation of DNA damage response and repair proteins SUMOylation of transcription cofactors SUMOylation of chromatin organization proteins SUMOylation of RNA binding proteins SUMOylation of DNA methylation proteins RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known Regulation of PTEN gene transcription Regulation of PTEN gene transcription Transcriptional Regulation by E2F6
Drugs
Diseases
GWAS		Hematocrit ( 32888494) Hemoglobin ( 32888494) Immunoglobulin light chain (AL) amyloidosis ( 28025584) Lymphocyte count ( 27863252 32888494) Menarche (age at onset) ( 25231870) Multiple myeloma ( 23955597 26007630 33875642) Multiple myeloma and monoclonal gammopathy ( 26007630) Neutrophil count ( 32888494) White blood cell count ( 27863252 32888494)	Asthma ( 32296059) Wegener's granulomatosis ( 23740775)
Interacting Genes		12 interacting genes: B3GNT5 H3-3A H3-4 H3C1 H3C14 PCGF1 PCGF5 PCGF6 RING1 RNF2 SUV39H2 ZRANB1	34 interacting genes: APP BMI1 CBX4 CBX7 CBX8 E2F6 ELAC2 ERG FBXO38 FHL1 GRSF1 H2AC4 H3-4 NFKBID NSD1 OGT PCGF3 PHC1 PIK3R3 PTEN RB1 RNF2 RYBP TP53 TRIM55 TRIM63 UBE2D1 UBE2D2 UBE2D3 UBE2D4 UBE2E2 UBE2E3 UBE2K ZIM3
Entrez ID		23492	6015
HPRD ID		12234	03624
Ensembl ID		ENSG00000100307	ENSG00000204227
Uniprot IDs		B0QYP2 O95931 Q4PNR6	A0A1U9X8F2 Q06587
PDB IDs		2K1B 2L12 2L1B 3GS2 4MN3 5EPJ 6V2R 8SII
Enriched GO Terms of Interacting Partners?		Chromatin Remodeling PRC1 Complex Chromatin Organization PcG Protein Complex Structural Constituent Of Chromatin Nucleoplasm Nucleosome Assembly Epigenetic Regulation Of Gene Expression Nucleosome Nucleosome Organization Histone H2AK119 Ubiquitin Ligase Activity Chromosome Protein-DNA Complex Assembly Sex Chromatin Negative Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of Biosynthetic Process Negative Regulation Of Macromolecule Metabolic Process Protein Heterodimerization Activity Negative Regulation Of DNA-templated Transcription Negative Regulation Of RNA Biosynthetic Process Zinc Ion Binding Negative Regulation Of Metabolic Process Nucleus Negative Regulation Of RNA Metabolic Process Negative Regulation Of Gene Expression, Epigenetic Negative Regulation Of Nucleobase-containing Compound Metabolic Process Negative Regulation Of Transcription By RNA Polymerase II Heterochromatin Lactosylceramide 1,3-N-acetyl-beta-D-glucosaminyltransferase Activity Regulation Of Gene Expression Gene Expression Regulation Of Macromolecule Biosynthetic Process RING-like Zinc Finger Domain Binding Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Negative Regulation Of Chromosome Condensation Regulation Of Macromolecule Metabolic Process Ubiquitin Ligase Complex Spermatogonial Cell Division Protein K29-linked Deubiquitination Histone H3K9 Trimethyltransferase Activity X Chromosome Pericentric Heterochromatin Formation Telomere Organization Protein K33-linked Deubiquitination Regulation Of Transcription By RNA Polymerase II Regulation Of RNA Metabolic Process Chromatin Binding Regulation Of Centromere Complex Assembly Heterochromatin Formation	PcG Protein Complex PRC1 Complex Ubiquitin Conjugating Enzyme Activity Protein K48-linked Ubiquitination Nucleus Chromatin Organization Negative Regulation Of Metabolic Process Negative Regulation Of Macromolecule Metabolic Process Ubiquitin-protein Transferase Activity Negative Regulation Of Transcription By RNA Polymerase II Negative Regulation Of Macromolecule Biosynthetic Process Protein Polyubiquitination Protein Modification By Small Protein Conjugation Negative Regulation Of Biosynthetic Process Negative Regulation Of DNA-templated Transcription Negative Regulation Of RNA Biosynthetic Process Negative Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Macromolecule Metabolic Process Regulation Of Metabolic Process Protein Ubiquitination Negative Regulation Of RNA Metabolic Process Regulation Of Gene Expression Chromatin Remodeling Post-translational Protein Modification Regulation Of Macromolecule Biosynthetic Process Regulation Of Transcription By RNA Polymerase II Protein Modification Process Nucleoplasm Chromatin Binding Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of RNA Metabolic Process Epigenetic Regulation Of Gene Expression Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Protein K11-linked Ubiquitination Regulation Of Primary Metabolic Process Heterochromatin Negative Regulation Of G1/S Transition Of Mitotic Cell Cycle Regulation Of Carbohydrate Catabolic Process Regulation Of Proteolysis Negative Regulation Of Cell Cycle G1/S Phase Transition RING-like Zinc Finger Domain Binding Regulation Of Phosphorus Metabolic Process Transferase Activity Protein K63-linked Ubiquitination Regulation Of G1/S Transition Of Mitotic Cell Cycle Regulation Of Purine Nucleotide Metabolic Process Histone H2AK119 Ubiquitin Ligase Activity Regulation Of Ubiquitin-dependent Protein Catabolic Process Regulation Of Cell Cycle G1/S Phase Transition
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