LEPROTL1 and MSR1

Number of citations of the paper that reports this interaction (PubMedID 25416956)
56

Data Source:
BioGRID (two hybrid, two hybrid)

		LEPROTL1	MSR1
Description		leptin receptor overlapping transcript like 1	macrophage scavenger receptor 1
Image		No pdb structure
GO Annotations	Cellular Component	Endosome Membrane	Collagen Trimer Plasma Membrane Membrane Endocytic Vesicle Membrane Low-density Lipoprotein Particle
	Molecular Function	Protein Binding Identical Protein Binding	Amyloid-beta Binding Scavenger Receptor Activity Protein Binding Low-density Lipoprotein Particle Binding Cargo Receptor Activity
	Biological Process	Late Endosome To Vacuole Transport Via Multivesicular Body Sorting Pathway Negative Regulation Of Growth Hormone Receptor Signaling Pathway	Endocytosis Receptor-mediated Endocytosis Phagocytosis, Engulfment Negative Regulation Of Gene Expression Positive Regulation Of Macrophage Derived Foam Cell Differentiation Positive Regulation Of Cholesterol Storage Cholesterol Transport Plasma Lipoprotein Particle Clearance Lipoprotein Transport Establishment Of Localization In Cell Amyloid-beta Clearance
Pathways			Scavenging by Class A Receptors Scavenging by Class A Receptors
Drugs
Diseases
GWAS			Alcohol dependence ( 26365420) Blood protein levels ( 23696881) HDL cholesterol levels in HIV infection ( 33109212) Hip circumference adjusted for BMI ( 28552196) Neurological blood protein biomarker levels ( 31320639) Triglyceride levels ( 32203549) Waist-hip index ( 34021172) Waist-to-hip ratio adjusted for BMI ( 34021172)
Interacting Genes		74 interacting genes: AGPAT4 ARL13B CD300C CD79A CISD2 CLDN7 CLEC2D CREB3L1 CYP4F2 EDA EHHADH ELOVL4 EMP1 FCER1G FFAR2 FMO1 GJA5 GJA8 GPR152 GPR42 GPX8 JPH1 KCNJ6 KLRG1 LMBR1 LMNA LNX1 LPAR3 LRRC4C MALL MSR1 NAT8 ORMDL3 PAQR8 PDZK1IP1 PEX16 PLP1 PPP3CC RBFA REEP4 REEP6 RNF5 RTP2 SCN3B SDCBP SFXN3 SLC16A2 SLC25A46 SLC30A4 SLC35H1 SLC71A2 SLC7A1 SMCO4 SPG21 SSMEM1 STING1 STX12 SYNDIG1 TGFA TMEM11 TMEM14B TMEM19 TMEM237 TMEM248 TMEM42 TMEM50A TMEM50B TMX2 TSNARE1 TSPAN2 TVP23A VAPA YIPF2 ZDHHC15	9 interacting genes: ADRB2 ATP6V0C FA2H HSPA1A LEPROTL1 MALL NKG7 SEC22A SNCA
Entrez ID		23484	4481
HPRD ID		09551	01092
Ensembl ID		ENSG00000104660	ENSG00000038945
Uniprot IDs		O95214 Q6FHL7	B4DDJ5 P21757
PDB IDs			7DPX
Enriched GO Terms of Interacting Partners?		Membrane Endoplasmic Reticulum Membrane Protein Binding Plasma Membrane Endoplasmic Reticulum Cellular Localization Myelination Axon Ensheathment SA Node Cell Action Potential Transmembrane Transport	Establishment Of Localization In Cell Inclusion Body Negative Regulation Of G Protein-coupled Receptor Signaling Pathway Regulation Of Systemic Arterial Blood Pressure By Norepinephrine-epinephrine Vesicle-mediated Transport Vacuolar Transport Positive Regulation Of Mini Excitatory Postsynaptic Potential Regulation Of Microtubule Polymerization Membrane Organization Natural Killer Cell Mediated Cytotoxicity Directed Against Tumor Cell Target Response To Desipramine Negative Regulation Of Norepinephrine Uptake Phospholipase D Inhibitor Activity Positive Regulation Of SNARE Complex Assembly Negative Regulation Of Dopamine Uptake Involved In Synaptic Transmission 4-hydroxysphinganine Ceramide Fatty Acyl 2-hydroxylase Activity Free Fatty Acid 2-hydroxylase Activity Fatty Acid 2-hydroxylase Activity Enzyme Binding Regulation Of Autophagy Beta2-adrenergic Receptor Activity Denatured Protein Binding Regulation Of Norepinephrine Uptake Negative Regulation Of Mitochondrial Electron Transport, NADH To Ubiquinone Positive Regulation Of Hydrogen Peroxide Catabolic Process Sebaceous Gland Cell Differentiation Glucosylceramide Biosynthetic Process Regulation Of Sebum Secreting Cell Proliferation Regulation Of Acinar Cell Proliferation Norepinephrine-epinephrine-mediated Vasodilation Involved In Regulation Of Systemic Arterial Blood Pressure Beta-adrenergic Receptor Activity Mitochondrial Membrane Organization Regulation Of Microtubule Polymerization Or Depolymerization Positive Regulation Of Defense Response Regulated Exocytosis Negative Regulation Of Serotonin Uptake Transporter Regulator Activity Negative Regulation Of Chaperone-mediated Autophagy Central Nervous System Myelin Maintenance Lysosome Norepinephrine Binding Lysosomal Transport Positive Regulation Of Organelle Organization Intracellular Transport Synaptic Vesicle Membrane Death Receptor Agonist Activity Cytolytic Granule Membrane Negative Regulation Of Dopamine Metabolic Process Regulation Of Serotonin Uptake Response To Psychosocial Stress
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