LEPROTL1 and EHHADH

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		LEPROTL1	EHHADH
Description		leptin receptor overlapping transcript like 1	enoyl-CoA hydratase and 3-hydroxyacyl CoA dehydrogenase
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Endosome Membrane	Peroxisome Peroxisomal Matrix Cytosol
	Molecular Function	Protein Binding Identical Protein Binding	Catalytic Activity (3S)-3-hydroxyacyl-CoA Dehydrogenase (NAD+) Activity Delta(3)-delta(2)-enoyl-CoA Isomerase Activity Enoyl-CoA Hydratase Activity Protein Binding Oxidoreductase Activity Long-chain (3S)-3-hydroxyacyl-CoA Dehydrogenase (NAD+) Activity Oxidoreductase Activity, Acting On The CH-OH Group Of Donors, NAD Or NADP As Acceptor Lyase Activity Isomerase Activity Intramolecular Oxidoreductase Activity, Transposing C=C Bonds 3-hydroxyacyl-CoA Dehydratase Activity Enzyme Binding NAD+ Binding
	Biological Process	Late Endosome To Vacuole Transport Via Multivesicular Body Sorting Pathway Negative Regulation Of Growth Hormone Receptor Signaling Pathway	Lipid Metabolic Process Fatty Acid Metabolic Process Fatty Acid Beta-oxidation Unsaturated Fatty Acid Biosynthetic Process Fatty Acid Beta-oxidation Using Acyl-CoA Oxidase Alpha-linolenic Acid Metabolic Process Long-chain Fatty Acid Biosynthetic Process Fatty Acid Derivative Biosynthetic Process
Pathways			Beta-oxidation of very long chain fatty acids Peroxisomal protein import Peroxisomal protein import
Drugs			NADH
Diseases
GWAS			Cognitive performance ( 19734545) Major depressive disorder ( 21042317 27519822)
Interacting Genes		74 interacting genes: AGPAT4 ARL13B CD300C CD79A CISD2 CLDN7 CLEC2D CREB3L1 CYP4F2 EDA EHHADH ELOVL4 EMP1 FCER1G FFAR2 FMO1 GJA5 GJA8 GPR152 GPR42 GPX8 JPH1 KCNJ6 KLRG1 LMBR1 LMNA LNX1 LPAR3 LRRC4C MALL MSR1 NAT8 ORMDL3 PAQR8 PDZK1IP1 PEX16 PLP1 PPP3CC RBFA REEP4 REEP6 RNF5 RTP2 SCN3B SDCBP SFXN3 SLC16A2 SLC25A46 SLC30A4 SLC35H1 SLC71A2 SLC7A1 SMCO4 SPG21 SSMEM1 STING1 STX12 SYNDIG1 TGFA TMEM11 TMEM14B TMEM19 TMEM237 TMEM248 TMEM42 TMEM50A TMEM50B TMX2 TSNARE1 TSPAN2 TVP23A VAPA YIPF2 ZDHHC15	98 interacting genes: AARS2 ACTB ACTG1 ADARB1 ANKRD36B ARMC12 ARMCX3 BHLHE40 BOLL CAT CBS CCDC102B CCDC13 CDR2L CEP83 CISD2 CLDN18 CLDN5 CLK2 CMTM6 COQ9 CYB561 CYB561A3 DAAM2 DERL3 DES DRC4 EMP1 ERGIC1 FGF14 FUNDC1 GMCL1 GRIPAP1 HID1 HIP1 HSD17B11 HTATIP2 JAGN1 KCTD9 KRTAP10-7 KRTAP4-11 LCN2 LEPROTL1 LYPD5 LZTFL1 LZTS2 MAB21L3 MID1 MTUS2 NACC1 NECAB2 OPRM1 ORMDL1 PAQR8 PICK1 PNMA1 PNMA5 PPP1R12C PRKRA PSTPIP1 PTGES REL RNF4 RPRM RUSF1 SCARA5 SCP2 SDR16C5 SGCB SLC14A2 SLC39A2 SMIM5 SMN1 SMN2 SSNA1 SSX2IP SYNGR3 TMEM121 TMEM17 TMEM31 TMEM35A TNIP1 TPP2 TRAF1 TRIM21 TRIM23 TRIM27 TRIM41 TRIM5 TRIM54 TRIM55 TRIM63 VAC14 ZBTB10 ZBTB26 ZBTB8A ZBTB9 ZCCHC17
Entrez ID		23484	1962
HPRD ID		09551	06125
Ensembl ID		ENSG00000104660	ENSG00000113790
Uniprot IDs		O95214 Q6FHL7	Q08426
PDB IDs
Enriched GO Terms of Interacting Partners?		Membrane Endoplasmic Reticulum Membrane Protein Binding Plasma Membrane Endoplasmic Reticulum Cellular Localization Myelination Axon Ensheathment SA Node Cell Action Potential Transmembrane Transport	Identical Protein Binding Protein Binding Ubiquitin Protein Ligase Activity Negative Regulation Of Protein Localization Innate Immune Response Protein K63-linked Ubiquitination Suppression Of Viral Release By Host Regulation Of Transepithelial Transport
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