CLASP1 and CKAP5

Number of citations of the paper that reports this interaction (PubMedID 30217970)
38

Data Source:
BioGRID (two hybrid)

		CLASP1	CKAP5
Description		cytoplasmic linker associated protein 1	cytoskeleton associated protein 5
Image
GO Annotations	Cellular Component	Chromosome, Centromeric Region Kinetochore Chromosome Cytoplasm Golgi Apparatus Centrosome Microtubule Organizing Center Spindle Kinetochore Microtubule Cytosol Cytoskeleton Microtubule Spindle Microtubule Cytoplasmic Microtubule Focal Adhesion Cell Cortex Membrane Cortical Microtubule Cytoskeleton Centrosomal Corona Microtubule Plus-end Basal Cortex Mitotic Spindle	Chromosome, Centromeric Region Kinetochore Spindle Pole Chromosome Nucleolus Cytoplasm Centrosome Spindle Cytosol Cytoskeleton Plasma Membrane Cilium Microtubule Cytoskeleton Membrane Protein-containing Complex Microtubule Plus-end Ciliary Basal Body Mitotic Spindle
	Molecular Function	Dystroglycan Binding Protein Binding Microtubule Binding Tubulin Binding Kinetochore Binding Microtubule Plus-end Binding	Protein Binding Microtubule Binding Tubulin Binding Ribonucleoprotein Complex Binding Cadherin Binding Microtubule Plus-end Binding Microtubule Plus End Polymerase
	Biological Process	Microtubule Cytoskeleton Organization Microtubule Bundle Formation Vesicle Targeting Microtubule Nucleation Negative Regulation Of Microtubule Depolymerization Golgi Organization Mitotic Spindle Organization Establishment Or Maintenance Of Cell Polarity Exit From Mitosis Regulation Of Gastrulation Positive Regulation Of Epithelial Cell Migration Regulation Of Epithelial To Mesenchymal Transition Establishment Of Cell Polarity Astral Microtubule Organization Microtubule Organizing Center Organization Negative Regulation Of Microtubule Polymerization Or Depolymerization Positive Regulation Of Microtubule Polymerization Microtubule Anchoring Establishment Of Mitotic Spindle Localization Positive Regulation Of Exocytosis Establishment Of Spindle Orientation Cell Division Negative Regulation Of Stress Fiber Assembly Regulation Of Focal Adhesion Assembly Basement Membrane Organization Positive Regulation Of Extracellular Matrix Disassembly Mitotic Spindle Assembly Negative Regulation Of Wound Healing, Spreading Of Epidermal Cells Positive Regulation Of Basement Membrane Assembly Involved In Embryonic Body Morphogenesis	Microtubule Depolymerization Spindle Organization Mitotic Spindle Organization Centrosome Cycle Establishment Or Maintenance Of Microtubule Cytoskeleton Polarity Protein-containing Complex Organization Microtubule Polymerization RNA Transport Centrosome Duplication Cell Division Positive Regulation Of Microtubule Nucleation
Pathways		Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal Separation of Sister Chromatids Resolution of Sister Chromatid Cohesion Regulation of PLK1 Activity at G2/M Transition Loss of Nlp from mitotic centrosomes Recruitment of mitotic centrosome proteins and complexes Loss of proteins required for interphase microtubule organization from the centrosome Recruitment of NuMA to mitotic centrosomes Role of ABL in ROBO-SLIT signaling Anchoring of the basal body to the plasma membrane RHO GTPases Activate Formins Mitotic Prometaphase AURKA Activation by TPX2 EML4 and NUDC in mitotic spindle formation	Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal Separation of Sister Chromatids Resolution of Sister Chromatid Cohesion Regulation of PLK1 Activity at G2/M Transition Loss of Nlp from mitotic centrosomes Recruitment of mitotic centrosome proteins and complexes Loss of proteins required for interphase microtubule organization from the centrosome Recruitment of NuMA to mitotic centrosomes Anchoring of the basal body to the plasma membrane RHO GTPases Activate Formins Mitotic Prometaphase AURKA Activation by TPX2 EML4 and NUDC in mitotic spindle formation
Drugs		Fostamatinib
Diseases
GWAS		Chloride levels ( 29403010) Cough in response to angiotensin-converting enzyme inhibitor drugs ( 28084903) HDL cholesterol x physical activity interaction (1df test) ( 30670697) HDL cholesterol x physical activity interaction (2df test) ( 30670697) Low density lipoprotein cholesterol levels ( 32154731) Metabolite levels ( 23823483) Potassium levels ( 29403010) Triglyceride levels ( 32154731)	Alzheimer's disease (late onset) ( 30820047) Alzheimer's disease or fasting glucose levels (pleiotropy) ( 30805717) Autism spectrum disorder or schizophrenia ( 28540026) Immunoglobulin A ( 20694011) Pulse pressure ( 30578418) Schizophrenia ( 29483656) Serum metabolite levels ( 33031748)
Interacting Genes		13 interacting genes: CEBPA CKAP5 EIF4ENIF1 JAKMIP2 MAP4 MAPRE1 MAPRE3 MARK3 MTNR1A MTNR1B PRKRA SRPK2 YWHAG	16 interacting genes: ARHGEF16 AURKA CACNA1A CEBPA CLASP1 CLK1 DYRK1A HSPA13 NDC80 OLIG2 PTPRN2 SLAIN2 SUMO2 TOP1 TTC3 USP19
Entrez ID		23332	9793
HPRD ID		09322	10830
Ensembl ID		ENSG00000074054	ENSG00000175216
Uniprot IDs		A0A8V8TLP7 A0A8V8TRF6 Q7Z460	Q14008
PDB IDs		4K92 6MQ5 6MQ7	4QMI 4QMJ
Enriched GO Terms of Interacting Partners?		Microtubule Binding Microtubule Polymerization Microtubule Plus-end Microtubule Plus-end Binding Mitotic Spindle Astral Microtubule End Microtubule Polymerization Or Depolymerization Melatonin Receptor Activity Spindle Organization Microtubule Cytoskeleton Organization Regulation Of Microtubule Polymerization Protein Polymerization Microtubule Cytoskeleton Microtubule Organizing Center Protein Localization To Microtubule Kinase Binding Regulation Of Microtubule Polymerization Or Depolymerization Microtubule Cytoskeleton Organization Involved In Mitosis Protein Serine/threonine Kinase Binding Organelle Organization Spindle Midzone Microtubule-based Process Regulation Of Microtubule Cytoskeleton Organization Cell Division Positive Regulation Of Microtubule Polymerization RNA Binding Establishment Of Spindle Orientation Cytoskeleton Organization Protein Localization To Cytoskeleton RNA Polymerase I Transcription Regulatory Region Sequence-specific DNA Binding G Protein-coupled Receptor Signaling Pathway, Coupled To Cyclic Nucleotide Second Messenger Microtubule Plus End Polymerase Protein Localization To Astral Microtubule Negative Regulation Of Deadenylation-dependent Decapping Of Nuclear-transcribed MRNA Establishment Of Spindle Localization Cellular Component Assembly Cytoplasmic Microtubule Regulation Of Microtubule-based Process Tubulin Binding Spindle Localization Protein Localization To Organelle Membraneless Organelle Assembly Response To Vitamin B2 C/EBP Complex Negative Regulation Of Non-motile Cilium Assembly Microtubule Stabilizing Activity Ciliary Basal Body Protein Localization To Mitotic Spindle Protein Localization To Spindle Microtubule Regulation Of Deadenylation-dependent Decapping Of Nuclear-transcribed MRNA Protein-containing Complex Assembly	Protein Serine/threonine/tyrosine Kinase Activity Spindle Assembly Involved In Female Meiosis I Animal Organ Regeneration Regulation Of Proteasomal Protein Catabolic Process Regulation Of Microtubule Polymerization Positive Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process HMG Box Domain Binding Regulation Of Microtubule-based Process Mitotic Spindle Organization Spindle Assembly Involved In Female Meiosis Meiotic Spindle Assembly Spindle Assembly Regulation Of Microtubule Polymerization Or Depolymerization Positive Regulation Of Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Proteasomal Protein Catabolic Process Meiotic Spindle Organization Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Proteolysis Involved In Protein Catabolic Process Regeneration Centrosome Microtubule Cytoskeleton Organization Involved In Mitosis Microtubule Plus-end Regulation Of Protein Catabolic Process Regulation Of Proteolysis Protein Modification Process Microtubule Nucleation Protein Serine/threonine Kinase Activity Regulation Of Microtubule Cytoskeleton Organization Spindle Organization Cell Cycle Phase Transition Kinetochore Positive Regulation Of Microtubule Polymerization Regulation Of Organelle Organization Regulation Of Ubiquitin-dependent Protein Catabolic Process Non-membrane Spanning Protein Tyrosine Kinase Activity Negative Regulation Of Microtubule Polymerization Or Depolymerization Peptidyl-serine Phosphorylation Spindle Microtubule Microtubule Cytoskeleton Organization Cell Division Establishment Of Spindle Orientation Establishment Of Mitotic Spindle Localization Positive Regulation Of Proteolysis RNA Polymerase I Transcription Regulatory Region Sequence-specific DNA Binding Positive Regulation Of Protein Catabolic Process Histone H3T45 Kinase Activity Kinetochore Adaptor Activity Centrosomal Corona Regulation Of Cytoskeleton Organization Establishment Of Spindle Localization
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