CKAP5 and TTC3

Number of citations of the paper that reports this interaction (PubMedID 35914814)
83

Data Source:
BioGRID (two hybrid)

		CKAP5	TTC3
Description		cytoskeleton associated protein 5	tetratricopeptide repeat domain 3
Image			No pdb structure
GO Annotations	Cellular Component	Chromosome, Centromeric Region Kinetochore Spindle Pole Chromosome Nucleolus Cytoplasm Centrosome Spindle Cytosol Cytoskeleton Plasma Membrane Cilium Microtubule Cytoskeleton Membrane Protein-containing Complex Microtubule Plus-end Ciliary Basal Body Mitotic Spindle	Nucleus Nucleoplasm Nucleolus Cytoplasm Golgi Apparatus Cytosol
	Molecular Function	Protein Binding Microtubule Binding Tubulin Binding Ribonucleoprotein Complex Binding Cadherin Binding Microtubule Plus-end Binding Microtubule Plus End Polymerase	Ubiquitin-protein Transferase Activity Protein Binding Zinc Ion Binding Transferase Activity Metal Ion Binding Ubiquitin Protein Ligase Activity
	Biological Process	Microtubule Depolymerization Spindle Organization Mitotic Spindle Organization Centrosome Cycle Establishment Or Maintenance Of Microtubule Cytoskeleton Polarity Protein-containing Complex Organization Microtubule Polymerization RNA Transport Centrosome Duplication Cell Division Positive Regulation Of Microtubule Nucleation	Ubiquitin-dependent Protein Catabolic Process Protein Ubiquitination Protein K48-linked Ubiquitination
Pathways		Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal Separation of Sister Chromatids Resolution of Sister Chromatid Cohesion Regulation of PLK1 Activity at G2/M Transition Loss of Nlp from mitotic centrosomes Recruitment of mitotic centrosome proteins and complexes Loss of proteins required for interphase microtubule organization from the centrosome Recruitment of NuMA to mitotic centrosomes Anchoring of the basal body to the plasma membrane RHO GTPases Activate Formins Mitotic Prometaphase AURKA Activation by TPX2 EML4 and NUDC in mitotic spindle formation
Drugs
Diseases
GWAS		Alzheimer's disease (late onset) ( 30820047) Alzheimer's disease or fasting glucose levels (pleiotropy) ( 30805717) Autism spectrum disorder or schizophrenia ( 28540026) Immunoglobulin A ( 20694011) Pulse pressure ( 30578418) Schizophrenia ( 29483656) Serum metabolite levels ( 33031748)	Eye color traits ( 20463881)
Interacting Genes		16 interacting genes: ARHGEF16 AURKA CACNA1A CEBPA CLASP1 CLK1 DYRK1A HSPA13 NDC80 OLIG2 PTPRN2 SLAIN2 SUMO2 TOP1 TTC3 USP19	75 interacting genes: AKAP17A AKT1 APP ARID1A ATF7IP ATP2A2 ATP6V0A1 BLOC1S2 CADPS CADPS2 CEP290 CHUK CKAP2 CKAP5 COG4 COPS5 DAAM2 DLEU7 DSCAM DSP DST EIF4G2 ETS2 EXOC4 FBXO7 FMNL2 FUT8 HARS1 HERC2 HSPB1 IFIT5 JADE2 JAK1 KANSL2 KCNJ15 LCOR LRPAP1 MDH1 MIR7-1 MORF4L1 NR1D2 NR1H2 NUFIP1 PAX6 PBX2 PCP4 PKNOX1 POLG PPFIBP1 PRKDC PSMD7 PSME1 RAI14 SH3BP5 SHROOM2 SMARCA4 SPARCL1 SPTAN1 SPTBN1 STXBP1 TAF1 THOP1 TJP1 TRAF6 TTN UBE2D2 UBE2E3 UBE3A UBR4 USP28 VHL WAC WHAMM XRN2 YWHAE
Entrez ID		9793	7267
HPRD ID		10830	03773
Ensembl ID		ENSG00000175216	ENSG00000182670
Uniprot IDs		Q14008	H7BZ57 P53804
PDB IDs		4QMI 4QMJ
Enriched GO Terms of Interacting Partners?		Protein Serine/threonine/tyrosine Kinase Activity Spindle Assembly Involved In Female Meiosis I Animal Organ Regeneration Regulation Of Proteasomal Protein Catabolic Process Regulation Of Microtubule Polymerization Positive Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process HMG Box Domain Binding Regulation Of Microtubule-based Process Mitotic Spindle Organization Spindle Assembly Involved In Female Meiosis Meiotic Spindle Assembly Spindle Assembly Regulation Of Microtubule Polymerization Or Depolymerization Positive Regulation Of Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Proteasomal Protein Catabolic Process Meiotic Spindle Organization Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Proteolysis Involved In Protein Catabolic Process Regeneration Centrosome Microtubule Cytoskeleton Organization Involved In Mitosis Microtubule Plus-end Regulation Of Protein Catabolic Process Regulation Of Proteolysis Protein Modification Process Microtubule Nucleation Protein Serine/threonine Kinase Activity Regulation Of Microtubule Cytoskeleton Organization Spindle Organization Cell Cycle Phase Transition Kinetochore Positive Regulation Of Microtubule Polymerization Regulation Of Organelle Organization Regulation Of Ubiquitin-dependent Protein Catabolic Process Non-membrane Spanning Protein Tyrosine Kinase Activity Negative Regulation Of Microtubule Polymerization Or Depolymerization Peptidyl-serine Phosphorylation Spindle Microtubule Microtubule Cytoskeleton Organization Cell Division Establishment Of Spindle Orientation Establishment Of Mitotic Spindle Localization Positive Regulation Of Proteolysis RNA Polymerase I Transcription Regulatory Region Sequence-specific DNA Binding Positive Regulation Of Protein Catabolic Process Histone H3T45 Kinase Activity Kinetochore Adaptor Activity Centrosomal Corona Regulation Of Cytoskeleton Organization Establishment Of Spindle Localization	Positive Regulation Of RNA Biosynthetic Process Protein-containing Complex Cytosol Positive Regulation Of DNA-templated Transcription Positive Regulation Of RNA Metabolic Process Protein Polyubiquitination Positive Regulation Of Nucleobase-containing Compound Metabolic Process Protein Modification By Small Protein Conjugation Regulation Of Cell Cycle G1/S Phase Transition Positive Regulation Of Macromolecule Biosynthetic Process Protein Ubiquitination Post-translational Protein Modification Positive Regulation Of Biosynthetic Process Dense Core Granule Exocytosis Regulation Of G1/S Transition Of Mitotic Cell Cycle Establishment Of Vesicle Localization Protein K48-linked Ubiquitination Vesicle Localization Ubiquitin-protein Transferase Activity Positive Regulation Of Metabolic Process Positive Regulation Of Transcription By RNA Polymerase II Calmodulin Binding Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Protein K11-linked Ubiquitination Organelle Localization Toll-like Receptor 4 Signaling Pathway Regulation Of Autophagy Regulation Of Gene Expression Cell Surface Toll-like Receptor Signaling Pathway Regulation Of Cell Cycle Protein Modification Process Regulation Of Metabolic Process Enzyme Binding Intracellular Receptor Signaling Pathway Regulation Of Macromolecule Biosynthetic Process Cadherin Binding Positive Regulation Of Macromolecule Metabolic Process Protein Localization To Cell-cell Junction Secretory Granule Localization Cell Surface Pattern Recognition Receptor Signaling Pathway Regulation Of Cellular Response To Stress Nucleoplasm Positive Regulation Of Protein Localization Regulation Of Cell Cycle Phase Transition Cell Cortex Regulation Of RNA Metabolic Process Golgi To Plasma Membrane Transport Ubiquitin-dependent Protein Catabolic Process Proteasome Complex
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