USP22 and PTGS2

Number of citations of the paper that reports this interaction (PubMedID 25817787)
0

Data Source:
BioGRID (enzymatic study)

		USP22	PTGS2
Description		ubiquitin specific peptidase 22	prostaglandin-endoperoxide synthase 2
Image		No pdb structure
GO Annotations	Cellular Component	SAGA Complex Nucleus Nucleoplasm Cytoplasm Transcription Factor TFTC Complex	Nucleus Nuclear Inner Membrane Nuclear Outer Membrane Cytoplasm Endoplasmic Reticulum Endoplasmic Reticulum Lumen Endoplasmic Reticulum Membrane Cytosol Membrane Neuron Projection
	Molecular Function	Transcription Coactivator Activity Cysteine-type Deubiquitinase Activity Protein Binding Peptidase Activity Cysteine-type Peptidase Activity Zinc Ion Binding Histone H4 Acetyltransferase Activity Hydrolase Activity Enzyme Binding Metal Ion Binding Histone H2B Deubiquitinase Activity Histone H2A Deubiquitinase Activity	Peroxidase Activity Prostaglandin-endoperoxide Synthase Activity Protein Binding Oxidoreductase Activity Oxidoreductase Activity, Acting On Single Donors With Incorporation Of Molecular Oxygen Oxidoreductase Activity, Acting On Single Donors With Incorporation Of Molecular Oxygen, Incorporation Of Two Atoms Of Oxygen Enzyme Binding Heme Binding Protein Homodimerization Activity Metal Ion Binding Dioxygenase Activity
	Biological Process	G2/M Transition Of Mitotic Cell Cycle Regulation Of DNA Repair Chromatin Organization Chromatin Remodeling Regulation Of Transcription By RNA Polymerase II Proteolysis Embryo Development Ending In Birth Or Egg Hatching Protein Deubiquitination Positive Regulation Of Type I Interferon Production Regulation Of RNA Splicing Positive Regulation Of DNA-templated Transcription Positive Regulation Of Mitotic Cell Cycle	Prostaglandin Biosynthetic Process Lipid Metabolic Process Fatty Acid Metabolic Process Fatty Acid Biosynthetic Process Prostaglandin Metabolic Process Response To Oxidative Stress Embryo Implantation Regulation Of Blood Pressure Response To Nematode Response To Selenium Ion Positive Regulation Of Vascular Endothelial Growth Factor Production Cyclooxygenase Pathway Lipoxygenase Pathway Positive Regulation Of Prostaglandin Biosynthetic Process Positive Regulation Of Fever Generation Prostaglandin Secretion Regulation Of Cell Population Proliferation Long-chain Fatty Acid Biosynthetic Process Negative Regulation Of Apoptotic Process Positive Regulation Of Nitric Oxide Biosynthetic Process Decidualization Regulation Of Inflammatory Response Brown Fat Cell Differentiation Cellular Response To Hypoxia Cellular Response To Non-ionic Osmotic Stress Cellular Response To Fluid Shear Stress Positive Regulation Of Transforming Growth Factor Beta Production Positive Regulation Of Cell Migration Involved In Sprouting Angiogenesis Positive Regulation Of Fibroblast Growth Factor Production Positive Regulation Of Brown Fat Cell Differentiation Positive Regulation Of Platelet-derived Growth Factor Production Cellular Oxidant Detoxification Regulation Of Neuroinflammatory Response Negative Regulation Of Intrinsic Apoptotic Signaling Pathway In Response To Osmotic Stress
Pathways		HATs acetylate histones Ub-specific processing proteases	Synthesis of 15-eicosatetraenoic acid derivatives Synthesis of Prostaglandins (PG) and Thromboxanes (TX) Interleukin-10 signaling Interleukin-4 and Interleukin-13 signaling Biosynthesis of DHA-derived SPMs Biosynthesis of EPA-derived SPMs Biosynthesis of DPAn-3 SPMs Biosynthesis of electrophilic ω-3 PUFA oxo-derivatives
Drugs			Dihomo-gamma-linolenic acid Icosapent Aminosalicylic acid Mesalazine Acetaminophen Indomethacin Indomethacin Nabumetone Ketorolac Tenoxicam Lenalidomide Celecoxib Tolmetin Rofecoxib Piroxicam Fenoprofen Valdecoxib Diclofenac Sulindac Flurbiprofen Etodolac Mefenamic acid Naproxen Sulfasalazine Phenylbutazone Meloxicam Carprofen Diflunisal Suprofen Salicylic acid Meclofenamic acid Acetylsalicylic acid Bromfenac Oxaprozin Ketoprofen Balsalazide Ibuprofen Lumiracoxib Magnesium salicylate Salsalate Choline magnesium trisalicylate Ginseng Antrafenine Antipyrine Tiaprofenic acid Etoricoxib Flufenamic acid Resveratrol 1-Phenylsulfonamide-3-Trifluoromethyl-5-Parabromophenylpyrazole Prostaglandin G2 Niflumic acid Licofelone Nimesulide Cimicoxib Lornoxicam Aceclofenac Nepafenac Parecoxib Pomalidomide Cannabidiol Loxoprofen Dexibuprofen Dexketoprofen Droxicam Tolfenamic acid Firocoxib Morniflumate Propacetamol Talniflumate Phenyl salicylate Trolamine salicylate Menthyl salicylate Glycol salicylate Dipyrithione Bryostatin 1 Alclofenac Bufexamac Bendazac Acemetacin Fish oil Medical Cannabis Nabiximols
Diseases			Esophageal cancer Penile cancer Cholangiocarcinoma
GWAS		Body mass index ( 26426971) Mosquito bite size ( 28199695)	Crohn's disease ( 26192919) Inflammatory bowel disease ( 26192919) Knee osteoarthritis ( 18471798)
Interacting Genes		18 interacting genes: B9D1 BAG4 CEBPA H2AC20 H2AC4 H2BC21 H2BC3 HEXA MRPL10 MRPL44 MTUS2 PALB2 PSME1 PTGS2 RCAN1 SCFD1 UBC ZEB1	13 interacting genes: ABHD16A CASK CAV1 CELF2 COPS5 COPS7A CTNNB1 ELAVL1 GAS5 NUCB1 PTGIS TP53 USP22
Entrez ID		23326	5743
HPRD ID		19411	02599
Ensembl ID		ENSG00000124422	ENSG00000073756
Uniprot IDs		Q9UPT9	P35354
PDB IDs			5F19 5F1A 5IKQ 5IKR 5IKT 5IKV 5KIR
Enriched GO Terms of Interacting Partners?		Protein Heterodimerization Activity Structural Constituent Of Chromatin Nucleosome	Negative Regulation Of Nitric Oxide Biosynthetic Process Enzyme Binding Regulation Of Fibroblast Proliferation Regulation Of Post-translational Protein Modification Negative Regulation Of Post-transcriptional Gene Silencing By Regulatory NcRNA Negative Regulation Of MiRNA-mediated Gene Silencing Protein Deneddylation Regulation Of Cellular Response To Growth Factor Stimulus Apoptotic Signaling Pathway MRNA 3'-UTR Binding Positive Regulation Of Execution Phase Of Apoptosis Regulation Of Protein Neddylation Protein Modification By Small Protein Removal Protein Neddylation Glandular Epithelial Cell Differentiation Disordered Domain Specific Binding Regulation Of MiRNA-mediated Gene Silencing Cellular Response To Oxygen Levels Regulation Of Post-transcriptional Gene Silencing Negative Regulation Of Fibroblast Proliferation COP9 Signalosome Regulation Of Programmed Necrotic Cell Death Regulation Of Intrinsic Apoptotic Signaling Pathway Positive Regulation Of Apoptotic Process Fibroblast Proliferation Regulation Of Protein Metabolic Process Regulation Of Cellular Response To Stress Establishment Of Localization In Cell Regulation Of Telomere Maintenance Via Telomerase Regulation Of Calcium Ion Import Regulation Of Neuroblast Proliferation T Cell Differentiation In Thymus Negative Regulation Of Gliogenesis Neuroblast Proliferation Positive Regulation Of Programmed Cell Death Regulation Of Calcium Ion Transport Negative Regulation Of Epithelial Cell Differentiation Gastrulation Inward Rectifier Potassium Channel Inhibitor Activity Basolateral Plasma Membrane Glial Cell Fate Determination Canonical Wnt Signaling Pathway Involved In Mesenchymal Stem Cell Differentiation Regulation Of Telomere Maintenance Via Telomere Lengthening Positive Regulation Of Autophagosome Size Prostaglandin-I Synthase Activity Negative Regulation Of Helicase Activity Negative Regulation Of G1 To G0 Transition Regulation Of RNA Metabolic Process Regulation Of Nitric Oxide Biosynthetic Process Positive Regulation Of Intrinsic Apoptotic Signaling Pathway
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