USP22 and B9D1

		USP22	B9D1
Description		ubiquitin specific peptidase 22	B9 domain containing 1
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	SAGA Complex Nucleus Nucleoplasm Cytoplasm Transcription Factor TFTC Complex	Cytoplasm Centrosome Cytosol Cytoskeleton Cilium Membrane Ciliary Transition Zone MKS Complex Ciliary Basal Body Cell Projection
	Molecular Function	Transcription Coactivator Activity Cysteine-type Deubiquitinase Activity Protein Binding Peptidase Activity Cysteine-type Peptidase Activity Zinc Ion Binding Histone H4 Acetyltransferase Activity Hydrolase Activity Enzyme Binding Metal Ion Binding Histone H2B Deubiquitinase Activity Histone H2A Deubiquitinase Activity	Protein Binding Hedgehog Receptor Activity
	Biological Process	G2/M Transition Of Mitotic Cell Cycle Regulation Of DNA Repair Chromatin Organization Chromatin Remodeling Regulation Of Transcription By RNA Polymerase II Proteolysis Embryo Development Ending In Birth Or Egg Hatching Protein Deubiquitination Positive Regulation Of Type I Interferon Production Regulation Of RNA Splicing Positive Regulation Of DNA-templated Transcription Positive Regulation Of Mitotic Cell Cycle	In Utero Embryonic Development Vasculature Development Smoothened Signaling Pathway Cell Projection Organization Regulation Of Protein Localization Embryonic Digit Morphogenesis Camera-type Eye Development Cilium Assembly Neuroepithelial Cell Differentiation
Pathways		HATs acetylate histones Ub-specific processing proteases	Anchoring of the basal body to the plasma membrane
Drugs
Diseases
GWAS		Body mass index ( 26426971) Mosquito bite size ( 28199695)
Interacting Genes		18 interacting genes: B9D1 BAG4 CEBPA H2AC20 H2AC4 H2BC21 H2BC3 HEXA MRPL10 MRPL44 MTUS2 PALB2 PSME1 PTGS2 RCAN1 SCFD1 UBC ZEB1	5 interacting genes: EXOSC10 GIT1 LIG4 TNFRSF13B USP22
Entrez ID		23326	27077
HPRD ID		19411	16866
Ensembl ID		ENSG00000124422	ENSG00000108641
Uniprot IDs		Q9UPT9	A0A0B4J223 A0A2R8Y646 A0A6Q8PFJ7 A8MYG7 B4DEW0 J3QKN6 Q9UPM9
PDB IDs
Enriched GO Terms of Interacting Partners?		Protein Heterodimerization Activity Structural Constituent Of Chromatin Nucleosome	Establishment Of Integrated Proviral Latency DNA Ligase (ATP) Activity Hematopoietic Progenitor Cell Differentiation DNA Ligase IV Complex Pro-B Cell Differentiation T Cell Receptor V(D)J Recombination Establishment Of Viral Latency DNA Ligase Activity DN2 Thymocyte Differentiation Regulation Of RNA Splicing Nuclear Polyadenylation-dependent SnoRNA Catabolic Process Nuclear Polyadenylation-dependent SnRNA Catabolic Process Nuclear Polyadenylation-dependent CUT Catabolic Process Nuclear Polyadenylation-dependent Antisense Transcript Catabolic Process Sno(s)RNA Catabolic Process Positive Regulation Of MRNA Cis Splicing, Via Spliceosome Histone H2B Deubiquitinase Activity Negative Regulation Of ARF Protein Signal Transduction Structural Constituent Of Postsynaptic Specialization Embryo Development Ending In Birth Or Egg Hatching Multicellular Organism Development DNA-dependent Protein Kinase-DNA Ligase 4 Complex Immunoglobulin V(D)J Recombination Regulation Of Chromosome Organization Nonhomologous End Joining Complex Nucleotide-excision Repair, DNA Gap Filling Exonucleolytic Trimming To Generate Mature 3'-end Of 5.8S RRNA From Tricistronic RRNA Transcript (SSU-rRNA, 5.8S RRNA, LSU-rRNA) TRNA Surveillance SnRNA Catabolic Process TRAMP-dependent TRNA Surveillance Pathway Poly(A)-dependent SnoRNA 3'-end Processing Nuclear Polyadenylation-dependent RRNA Catabolic Process CUT Catabolic Process Histone H2A Deubiquitinase Activity Intramembranous Ossification Positive Regulation Of Microtubule Nucleation Motor Learning Positive Regulation Of Receptor Catabolic Process Double-strand Break Repair Via Classical Nonhomologous End Joining Lymphoid Progenitor Cell Differentiation Single Strand Break Repair AMP Binding Regulation Of Organelle Organization TRNA Decay RRNA 3'-end Processing Nuclear MRNA Surveillance Regulation Of Telomerase RNA Localization To Cajal Body Nucleolar Exosome (RNase Complex) Histone H4 Acetyltransferase Activity Maintenance Of Postsynaptic Specialization Structure
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