SIN3B and POR

		SIN3B	POR
Description		SIN3 transcription regulator family member B	cytochrome p450 oxidoreductase
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GO Annotations	Cellular Component	Chromatin X Chromosome Y Chromosome XY Body Nucleus Nucleoplasm Cytoplasm Autosome Sin3-type Complex	Cytoplasm Endoplasmic Reticulum Endoplasmic Reticulum Membrane Cytosol Membrane Intracellular Membrane-bounded Organelle
	Molecular Function	Chromatin Binding Transcription Corepressor Activity Protein Binding	NADPH-hemoprotein Reductase Activity Cytochrome-b5 Reductase Activity, Acting On NAD(P)H Protein Binding Enzyme Activator Activity Nitric Oxide Dioxygenase NAD(P)H Activity Electron Transfer Activity FMN Binding Oxidoreductase Activity Hydrolase Activity Enzyme Binding Iron-cytochrome-c Reductase Activity Flavin Adenine Dinucleotide Binding NADP Binding
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Regulation Of DNA-templated Transcription Negative Regulation Of Cell Migration Negative Regulation Of DNA-templated Transcription	Xenobiotic Metabolic Process Nitric Oxide Biosynthetic Process Response To Nutrient Response To Xenobiotic Stimulus Carnitine Metabolic Process Response To Hormone Flavonoid Metabolic Process Fatty Acid Oxidation Electron Transport Chain Positive Regulation Of Chondrocyte Differentiation Negative Regulation Of Apoptotic Process Nitrate Catabolic Process Positive Regulation Of Smoothened Signaling Pathway Nitric Oxide Catabolic Process Positive Regulation Of Growth Plate Cartilage Chondrocyte Proliferation Demethylation Cellular Response To Gonadotropin Stimulus Cellular Response To Follicle-stimulating Hormone Stimulus Cellular Response To Peptide Hormone Stimulus Response To Dexamethasone Positive Regulation Of Steroid Hormone Biosynthetic Process Organofluorine Metabolic Process
Pathways		NoRC negatively regulates rRNA expression RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function	Cytochrome P450 - arranged by substrate type
Drugs			Flavin adenine dinucleotide Flavin mononucleotide Nicotinamide adenine dinucleotide phosphate
Diseases			46,XX disorders of sex development (Disorders related to androgen excess), including: Congenital adrenal hyperplasias; Glucocorticoid resistance; Aromatase deficiency Craniosynostosis, including: Pfeiffer syndrome; Apert syndrome; Crouzon syndrome; Jackson-Weiss syndrome; Beare-Stevenson syndrome; Muenke craniosynostosis; Saethre-Chotzen syndrome; Craniosynostosis Boston type; Antley-Bixler syndrome; Carpenter syndrome; Craniofrontonasal dysplasia; Noonan syndrome; Baller-Gerold syndrome 46,XY disorders of sex development (Disorders in androgen synthesis or action), including: Congenital adrenal hyperplasias; Leydig cell hypoplasia; Androgen insensitivity syndrome (AIS)
GWAS			Bitter beverage consumption ( 31046077) Bitter non-alcoholic beverage consumption ( 31046077) Caffeine consumption from coffee ( 33287642) Caffeine consumption from coffee or tea ( 33287642) Caffeine consumption from tea ( 33287642) Coffee consumption ( 25288136 31959922 31046077) Coffee consumption (cups per day) ( 31837886 25288136) Eosinophil percentage of white cells ( 32888494) Estimated glomerular filtration rate ( 31152163 31451708) High light scatter reticulocyte count ( 32888494) Low density lipoprotein cholesterol levels ( 32154731) Metabolite levels ( 23823483) Platelet count ( 32888494) Response to cognitive-behavioural therapy in major depressive disorder ( 31123309) Reticulocyte count ( 32888494) Urinary albumin-to-creatinine ratio ( 31511532)
Interacting Genes		22 interacting genes: AURKA COPS2 GDF15 H3-4 HDAC1 HDAC9 IKZF1 IKZF4 MAD1L1 MXD1 MXI1 NR1D2 POR REST RNF220 SETDB1 SMARCA2 SMARCA4 SMARCB1 SMARCE1 TP53 ZBTB16	21 interacting genes: CYB5A CYP17A1 CYP1A2 CYP2A6 CYP2C19 CYP2C9 CYP2D6 CYP2E1 CYP3A4 EHMT2 FANCC HMOX1 LINC01554 PSPHP1 RABEPK RPS4X SIN3B SLC39A2 STAT1 TGFBI XRCC6
Entrez ID		23309	5447
HPRD ID		09691	00485
Ensembl ID		ENSG00000127511	ENSG00000127948
Uniprot IDs		B7Z392 M0QYC5 O75182	A0A9L9PY49 P16435
PDB IDs		8BPA 8BPB 8BPC 8C60	1B1C 3FJO 3QE2 3QFC 3QFR 3QFS 3QFT 5EMN 5FA6
Enriched GO Terms of Interacting Partners?		Positive Regulation Of Stem Cell Population Maintenance Negative Regulation Of DNA-templated Transcription Negative Regulation Of RNA Biosynthetic Process Chromatin Organization Negative Regulation Of RNA Metabolic Process Chromatin Remodeling Negative Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of Nucleobase-containing Compound Metabolic Process Negative Regulation Of Biosynthetic Process Regulation Of Stem Cell Population Maintenance BBAF Complex DNA Binding Negative Regulation Of Macromolecule Metabolic Process NpBAF Complex NBAF Complex Negative Regulation Of Metabolic Process Regulation Of Cell Differentiation Negative Regulation Of Transcription By RNA Polymerase II Nucleoplasm Protein-containing Complex Nucleus Regulation Of Transcription By RNA Polymerase II Regulation Of Cell Development Regulation Of Primary Metabolic Process Regulation Of DNA-templated Transcription Epigenetic Regulation Of Gene Expression Regulation Of RNA Biosynthetic Process Host-mediated Perturbation Of Viral Transcription Regulation Of Nucleotide-excision Repair SWI/SNF Complex Regulation Of Metabolic Process Regulation Of Mitotic Metaphase/anaphase Transition Regulation Of Developmental Process Regulation Of RNA Metabolic Process Regulation Of G0 To G1 Transition Regulation Of Mitotic Cell Cycle Phase Transition Regulation Of Gene Expression Nucleosomal DNA Binding Regulation Of Sister Chromatid Segregation Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Myoblast Differentiation Positive Regulation Of T Cell Differentiation Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Chromosome Organization Positive Regulation Of Cell Differentiation Regulation Of Chromosome Segregation Brahma Complex Positive Regulation Of Lymphocyte Differentiation Positive Regulation Of Cell Development RSC-type Complex	Monoterpenoid Metabolic Process Oxidoreductase Activity, Acting On Paired Donors, With Incorporation Or Reduction Of Molecular Oxygen, Reduced Flavin Or Flavoprotein As One Donor, And Incorporation Of One Atom Of Oxygen Heme Binding Oxidoreductase Activity, Acting On Paired Donors, With Incorporation Or Reduction Of Molecular Oxygen Monooxygenase Activity Xenobiotic Catabolic Process Iron Ion Binding Olefinic Compound Metabolic Process Intracellular Membrane-bounded Organelle Epoxygenase P450 Pathway Steroid Hydroxylase Activity Arachidonate Metabolic Process Long-chain Fatty Acid Metabolic Process Xenobiotic Metabolic Process Oxidative Demethylation Steroid Metabolic Process Demethylation Long-chain Fatty Acid Biosynthetic Process Terpenoid Metabolic Process Unsaturated Fatty Acid Metabolic Process Icosanoid Metabolic Process Isoprenoid Metabolic Process Oxidoreductase Activity Caffeine Oxidase Activity Enzyme Binding Oxygen Binding Fatty Acid Metabolic Process Estrogen Metabolic Process Estrogen 2-hydroxylase Activity Endoplasmic Reticulum Membrane Alkaloid Metabolic Process Omega-hydroxylase P450 Pathway Arachidonate Epoxygenase Activity Secondary Metabolic Process Fatty Acid Biosynthetic Process Monocarboxylic Acid Metabolic Process (S)-limonene 7-monooxygenase Activity (R)-limonene 6-monooxygenase Activity (S)-limonene 6-monooxygenase Activity Anandamide 8,9 Epoxidase Activity Anandamide 11,12 Epoxidase Activity Anandamide 14,15 Epoxidase Activity Hormone Metabolic Process Endoplasmic Reticulum Coumarin Metabolic Process Alkaloid Catabolic Process Long-chain Fatty Acid Omega-1 Hydroxylase Activity Cholesterol Metabolic Process Carboxylic Acid Biosynthetic Process Small Molecule Biosynthetic Process
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