POR and PSPHP1

		POR	PSPHP1
Description		cytochrome p450 oxidoreductase	phosphoserine phosphatase pseudogene 1
Image			No pdb structure
GO Annotations	Cellular Component	Cytoplasm Endoplasmic Reticulum Endoplasmic Reticulum Membrane Cytosol Membrane Intracellular Membrane-bounded Organelle
	Molecular Function	NADPH-hemoprotein Reductase Activity Cytochrome-b5 Reductase Activity, Acting On NAD(P)H Protein Binding Enzyme Activator Activity Nitric Oxide Dioxygenase NAD(P)H Activity Electron Transfer Activity FMN Binding Oxidoreductase Activity Hydrolase Activity Enzyme Binding Iron-cytochrome-c Reductase Activity Flavin Adenine Dinucleotide Binding NADP Binding
	Biological Process	Xenobiotic Metabolic Process Nitric Oxide Biosynthetic Process Response To Nutrient Response To Xenobiotic Stimulus Carnitine Metabolic Process Response To Hormone Flavonoid Metabolic Process Fatty Acid Oxidation Electron Transport Chain Positive Regulation Of Chondrocyte Differentiation Negative Regulation Of Apoptotic Process Nitrate Catabolic Process Positive Regulation Of Smoothened Signaling Pathway Nitric Oxide Catabolic Process Positive Regulation Of Growth Plate Cartilage Chondrocyte Proliferation Demethylation Cellular Response To Gonadotropin Stimulus Cellular Response To Follicle-stimulating Hormone Stimulus Cellular Response To Peptide Hormone Stimulus Response To Dexamethasone Positive Regulation Of Steroid Hormone Biosynthetic Process Organofluorine Metabolic Process
Pathways		Cytochrome P450 - arranged by substrate type
Drugs		Flavin adenine dinucleotide Flavin mononucleotide Nicotinamide adenine dinucleotide phosphate
Diseases		46,XX disorders of sex development (Disorders related to androgen excess), including: Congenital adrenal hyperplasias; Glucocorticoid resistance; Aromatase deficiency Craniosynostosis, including: Pfeiffer syndrome; Apert syndrome; Crouzon syndrome; Jackson-Weiss syndrome; Beare-Stevenson syndrome; Muenke craniosynostosis; Saethre-Chotzen syndrome; Craniosynostosis Boston type; Antley-Bixler syndrome; Carpenter syndrome; Craniofrontonasal dysplasia; Noonan syndrome; Baller-Gerold syndrome 46,XY disorders of sex development (Disorders in androgen synthesis or action), including: Congenital adrenal hyperplasias; Leydig cell hypoplasia; Androgen insensitivity syndrome (AIS)
GWAS		Bitter beverage consumption ( 31046077) Bitter non-alcoholic beverage consumption ( 31046077) Caffeine consumption from coffee ( 33287642) Caffeine consumption from coffee or tea ( 33287642) Caffeine consumption from tea ( 33287642) Coffee consumption ( 25288136 31959922 31046077) Coffee consumption (cups per day) ( 31837886 25288136) Eosinophil percentage of white cells ( 32888494) Estimated glomerular filtration rate ( 31152163 31451708) High light scatter reticulocyte count ( 32888494) Low density lipoprotein cholesterol levels ( 32154731) Metabolite levels ( 23823483) Platelet count ( 32888494) Response to cognitive-behavioural therapy in major depressive disorder ( 31123309) Reticulocyte count ( 32888494) Urinary albumin-to-creatinine ratio ( 31511532)
Interacting Genes		21 interacting genes: CYB5A CYP17A1 CYP1A2 CYP2A6 CYP2C19 CYP2C9 CYP2D6 CYP2E1 CYP3A4 EHMT2 FANCC HMOX1 LINC01554 PSPHP1 RABEPK RPS4X SIN3B SLC39A2 STAT1 TGFBI XRCC6	1 interacting genes: POR
Entrez ID		5447	8781
HPRD ID		00485	11972
Ensembl ID		ENSG00000127948	ENSG00000226278
Uniprot IDs		A0A9L9PY49 P16435
PDB IDs		1B1C 3FJO 3QE2 3QFC 3QFR 3QFS 3QFT 5EMN 5FA6
Enriched GO Terms of Interacting Partners?		Monoterpenoid Metabolic Process Oxidoreductase Activity, Acting On Paired Donors, With Incorporation Or Reduction Of Molecular Oxygen, Reduced Flavin Or Flavoprotein As One Donor, And Incorporation Of One Atom Of Oxygen Heme Binding Oxidoreductase Activity, Acting On Paired Donors, With Incorporation Or Reduction Of Molecular Oxygen Monooxygenase Activity Xenobiotic Catabolic Process Iron Ion Binding Olefinic Compound Metabolic Process Intracellular Membrane-bounded Organelle Epoxygenase P450 Pathway Steroid Hydroxylase Activity Arachidonate Metabolic Process Long-chain Fatty Acid Metabolic Process Xenobiotic Metabolic Process Oxidative Demethylation Steroid Metabolic Process Demethylation Long-chain Fatty Acid Biosynthetic Process Terpenoid Metabolic Process Unsaturated Fatty Acid Metabolic Process Icosanoid Metabolic Process Isoprenoid Metabolic Process Oxidoreductase Activity Caffeine Oxidase Activity Enzyme Binding Oxygen Binding Fatty Acid Metabolic Process Estrogen Metabolic Process Estrogen 2-hydroxylase Activity Endoplasmic Reticulum Membrane Alkaloid Metabolic Process Omega-hydroxylase P450 Pathway Arachidonate Epoxygenase Activity Secondary Metabolic Process Fatty Acid Biosynthetic Process Monocarboxylic Acid Metabolic Process (S)-limonene 7-monooxygenase Activity (R)-limonene 6-monooxygenase Activity (S)-limonene 6-monooxygenase Activity Anandamide 8,9 Epoxidase Activity Anandamide 11,12 Epoxidase Activity Anandamide 14,15 Epoxidase Activity Hormone Metabolic Process Endoplasmic Reticulum Coumarin Metabolic Process Alkaloid Catabolic Process Long-chain Fatty Acid Omega-1 Hydroxylase Activity Cholesterol Metabolic Process Carboxylic Acid Biosynthetic Process Small Molecule Biosynthetic Process	Iron-cytochrome-c Reductase Activity Positive Regulation Of Growth Plate Cartilage Chondrocyte Proliferation Nitric Oxide Dioxygenase NAD(P)H Activity Nitrate Catabolic Process Nitric Oxide Catabolic Process Organofluorine Metabolic Process Nitrate Metabolic Process NADPH-hemoprotein Reductase Activity Positive Regulation Of Steroid Hormone Biosynthetic Process Cytochrome-b5 Reductase Activity, Acting On NAD(P)H Demethylation Flavonoid Metabolic Process Positive Regulation Of Hormone Biosynthetic Process Carnitine Metabolic Process Cellular Response To Follicle-stimulating Hormone Stimulus Response To Follicle-stimulating Hormone FMN Binding Amino-acid Betaine Metabolic Process Regulation Of Steroid Hormone Biosynthetic Process Positive Regulation Of Chondrocyte Differentiation Cellular Response To Gonadotropin Stimulus Nitric Oxide Biosynthetic Process Regulation Of Hormone Biosynthetic Process Response To Gonadotropin Nitric Oxide Metabolic Process Reactive Nitrogen Species Metabolic Process Positive Regulation Of Cartilage Development Regulation Of Hormone Metabolic Process Positive Regulation Of Steroid Biosynthetic Process NADP Binding Positive Regulation Of Smoothened Signaling Pathway Positive Regulation Of Steroid Metabolic Process Response To Dexamethasone Regulation Of Chondrocyte Differentiation Electron Transfer Activity Flavin Adenine Dinucleotide Binding Regulation Of Cartilage Development Enzyme Activator Activity Fatty Acid Oxidation Regulation Of Steroid Biosynthetic Process Lipid Oxidation Regulation Of Smoothened Signaling Pathway Positive Regulation Of Lipid Biosynthetic Process Electron Transport Chain Regulation Of Steroid Metabolic Process Xenobiotic Metabolic Process Response To Glucocorticoid Lipid Modification Intracellular Membrane-bounded Organelle Positive Regulation Of Lipid Metabolic Process
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