JMJD6 and RSPO2

Number of citations of the paper that reports this interaction (PubMedID 23455924)
0

Data Source:
BioGRID (two hybrid)

		JMJD6	RSPO2
Description		jumonji domain containing 6, arginine demethylase and lysine hydroxylase	R-spondin 2
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GO Annotations	Cellular Component	Nucleus Nucleoplasm Nucleolus Cytoplasm Cytosol Plasma Membrane Ribonucleoprotein Complex	Extracellular Region Extracellular Space Cell Surface
	Molecular Function	RNA Binding Single-stranded RNA Binding Iron Ion Binding Protein Binding Oxidoreductase Activity Histone Demethylase Activity Histone H3R2 Demethylase Activity Histone H4R3 Demethylase Activity Oxidative RNA Demethylase Activity Signaling Receptor Activity Identical Protein Binding Metal Ion Binding Dioxygenase Activity Peptidyl-lysine 5-dioxygenase Activity P-TEFb Complex Binding Protein Demethylase Activity Transcription Regulator Activator Activity	Signaling Receptor Binding Protein Binding Heparin Binding BMP Receptor Binding
	Biological Process	Blood Vessel Development Kidney Development Sprouting Angiogenesis Chromatin Organization Chromatin Remodeling MRNA Processing Phagocytosis Cell Surface Receptor Signaling Pathway Heart Development RNA Splicing Peptidyl-lysine Hydroxylation To 5-hydroxy-L-lysine Cell Differentiation Lung Development Negative Regulation Of Protein Homooligomerization T Cell Differentiation In Thymus Oxidative RNA Demethylation Macrophage Activation Apoptotic Cell Clearance Recognition Of Apoptotic Cell Positive Regulation Of DNA-templated Transcription Positive Regulation Of Transcription By RNA Polymerase II Regulation Of MRNA Splicing, Via Spliceosome Erythrocyte Development Protein Homooligomerization Retina Development In Camera-type Eye Membraneless Organelle Assembly	Osteoblast Differentiation Wnt Signaling Pathway Positive Regulation Of Wnt Signaling Pathway Bone Mineralization Embryonic Forelimb Morphogenesis Embryonic Hindlimb Morphogenesis Negative Regulation Of Odontogenesis Of Dentin-containing Tooth Canonical Wnt Signaling Pathway Limb Development Lung Growth Epithelial Tube Branching Involved In Lung Morphogenesis Trachea Cartilage Morphogenesis Dopaminergic Neuron Differentiation Positive Regulation Of Canonical Wnt Signaling Pathway
Pathways		HDMs demethylate histones Protein hydroxylation	Regulation of FZD by ubiquitination
Drugs
Diseases
GWAS		Neutrophil count ( 32888494) Retinal arteriolar caliber ( 23776548)	Acute lymphoblastic leukemia (childhood) ( 22076464) Blond vs. brown/black hair color ( 30531825) Blood protein levels ( 30072576) BMI x environmental factors (excluding physical activity) interaction ( 33654129) Brain morphology (MOSTest) ( 32665545) Dupuytren's disease ( 21732829 28886342) Heel bone mineral density ( 30598549) Hip circumference adjusted for BMI ( 28552196) Intake of total sugars ( 31005972) Macular thickness ( 30535121) Male-pattern baldness ( 28196072 29146897) Ossification of the posterior longitudinal ligament of the spine ( 25064007)
Interacting Genes		31 interacting genes: AEBP2 ANKEF1 BAG5 CCNL1 CENPL CXCL14 DIP2A FGD5 FRMD6 GNA14 H2BC11 H3C1 H4C1 HMGXB4 IRF3 LARP7 LIAT1 NAA50 NFIX NHP2 OGT PRPF38A PSMC1 RNF5 RSPO2 SLFN12 SLU7 STAC3 TAF1A U2AF1 ZNF451	15 interacting genes: CATSPER1 CYSRT1 HOXA1 JMJD6 KRTAP10-1 KRTAP10-4 KRTAP10-6 KRTAP10-7 KRTAP10-9 KRTAP12-3 PLEKHF2 SLC39A7 SUV39H1 ZNF330 ZNF837
Entrez ID		23210	340419
HPRD ID		05371	17536
Ensembl ID		ENSG00000070495	ENSG00000147655
Uniprot IDs		B2WTI3 B2WTI4 Q6NYC1	B3KVP3 Q6UXX9
PDB IDs		3K2O 3LD8 3LDB 6BNH 6GDY 6MEV	8XFP 8XFS 8XFT 8XUM 8Y69
Enriched GO Terms of Interacting Partners?		Pre-mRNA 3'-splice Site Binding SnRNA Modification Nucleoplasm Nucleus	Keratin Filament Intermediate Filament Semicircular Canal Formation Skin Epidermis Development Histone H4R3 Demethylase Activity Peptidyl-lysine Hydroxylation To 5-hydroxy-L-lysine Peptidyl-lysine 5-dioxygenase Activity Histone H3R2 Demethylase Activity Oxidative RNA Demethylation
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