RSPO2

Description		R-spondin 2
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GO Annotations	Cellular Component	Extracellular Region Extracellular Space Cell Surface
	Molecular Function	Signaling Receptor Binding Protein Binding Heparin Binding BMP Receptor Binding
	Biological Process	Osteoblast Differentiation Wnt Signaling Pathway Positive Regulation Of Wnt Signaling Pathway Bone Mineralization Embryonic Forelimb Morphogenesis Embryonic Hindlimb Morphogenesis Negative Regulation Of Odontogenesis Of Dentin-containing Tooth Canonical Wnt Signaling Pathway Limb Development Lung Growth Epithelial Tube Branching Involved In Lung Morphogenesis Trachea Cartilage Morphogenesis Dopaminergic Neuron Differentiation Positive Regulation Of Canonical Wnt Signaling Pathway
Pathways		Regulation of FZD by ubiquitination
Drugs
Diseases
GWAS		Acute lymphoblastic leukemia (childhood) ( 22076464) Blond vs. brown/black hair color ( 30531825) Blood protein levels ( 30072576) BMI x environmental factors (excluding physical activity) interaction ( 33654129) Brain morphology (MOSTest) ( 32665545) Dupuytren's disease ( 21732829 28886342) Heel bone mineral density ( 30598549) Hip circumference adjusted for BMI ( 28552196) Intake of total sugars ( 31005972) Macular thickness ( 30535121) Male-pattern baldness ( 28196072 29146897) Ossification of the posterior longitudinal ligament of the spine ( 25064007)
Novel Interacting Genes		15 novel interacting genes: CATSPER1 CYSRT1 HOXA1 JMJD6 KRTAP10-1 KRTAP10-4 KRTAP10-6 KRTAP10-7 KRTAP10-9 KRTAP12-3 PLEKHF2 SLC39A7 SUV39H1 ZNF330 ZNF837
Interacting Genes		15 interacting genes: CATSPER1 CYSRT1 HOXA1 JMJD6 KRTAP10-1 KRTAP10-4 KRTAP10-6 KRTAP10-7 KRTAP10-9 KRTAP12-3 PLEKHF2 SLC39A7 SUV39H1 ZNF330 ZNF837
Entrez ID		340419
HPRD ID		17536
Ensembl ID		ENSG00000147655
Uniprot IDs		B3KVP3 Q6UXX9
PDB IDs		8XFP 8XFS 8XFT 8XUM 8Y69
Enriched GO Terms of Interacting Partners?		Keratin Filament Intermediate Filament Semicircular Canal Formation Skin Epidermis Development Histone H4R3 Demethylase Activity Peptidyl-lysine Hydroxylation To 5-hydroxy-L-lysine Peptidyl-lysine 5-dioxygenase Activity Histone H3R2 Demethylase Activity Oxidative RNA Demethylation
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