LRCH1 and TMEM14A

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		LRCH1	TMEM14A
Description		leucine rich repeats and calponin homology domain containing 1	transmembrane protein 14A
Image		No pdb structure
GO Annotations	Cellular Component	Cytoplasm	Mitochondrion Endoplasmic Reticulum Endoplasmic Reticulum Membrane Membrane Mitochondrial Membrane
	Molecular Function	Protein Binding	Protein Binding
	Biological Process	Negative Regulation Of GTPase Activity Cellular Response To Chemokine Negative Regulation Of T Cell Migration	Apoptotic Process Negative Regulation Of Apoptotic Process Negative Regulation Of Mitochondrial Outer Membrane Permeabilization Involved In Apoptotic Signaling Pathway
Pathways
Drugs
Diseases
GWAS		Brain morphology (MOSTest) ( 32665545) Electrocardiogram morphology (amplitude at temporal datapoints) ( 32916098) Immature fraction of reticulocytes ( 32888494) Mean platelet volume ( 27863252 32888494) Mosquito bite size ( 28199695) Optic disc size ( 31809533) Platelet count ( 32888494) Platelet distribution width ( 27863252 32888494) PR interval ( 30679814 32439900 30046033) PR segment duration ( 24850809) Pulse pressure ( 30578418) QRS complex (12-leadsum) ( 27659466) Systolic blood pressure ( 30224653)	Metabolite levels ( 23823483) Perceived intensity of neohesperidin dihydrochalcone ( 31005972) Response to hepatitis B vaccine ( 29534301)
Interacting Genes		3 interacting genes: RB1 TMEM14A TMEM14B	39 interacting genes: AQP6 CLN8 CPLX4 CREB3 CREB3L1 CXCR3 ERBB3 ERBB4 ERGIC3 ERMAP FAM209A FKBP7 IER3IP1 KCNK5 LMNA LRCH1 LXN MMGT1 MTNR1A MTNR1B MUC1 NEMP1 PDZK1IP1 SAR1A SCN3B SERINC2 SLC10A6 SLC18A1 SLC19A3 SLC35H1 SLC7A1 SSMEM1 TMEM14B TMEM179B TMEM31 TMEM51 TMEM80 TMEM86B USP18
Entrez ID		23143	28978
HPRD ID		14307	15522
Ensembl ID		ENSG00000136141	ENSG00000096092
Uniprot IDs		Q9Y2L9	Q9Y6G1
PDB IDs			2LOO 2LOP
Enriched GO Terms of Interacting Partners?		Negative Regulation Of Myofibroblast Differentiation Regulation Of G1/S Transition Of Mitotic Cell Cycle Sister Chromatid Biorientation Maintenance Of Mitotic Sister Chromatid Cohesion Regulation Of Lipid Kinase Activity Regulation Of Mitotic Cell Cycle Phase Transition Negative Regulation Of Hepatocyte Apoptotic Process Enucleate Erythrocyte Differentiation Negative Regulation Of Apoptotic Signaling Pathway Glial Cell Apoptotic Process Regulation Of Cell Cycle G1/S Phase Transition Rb-E2F Complex Regulation Of Centromere Complex Assembly Chromatin Lock Complex Positive Regulation Of Collagen Fibril Organization Mitochondrial Membrane Regulation Of Myofibroblast Differentiation Regulation Of Apoptotic Signaling Pathway Regulation Of Collagen Fibril Organization Cyclin/CDK Positive Transcription Elongation Factor Complex Importin-alpha Family Protein Binding Positive Regulation Of Transcription Regulatory Region DNA Binding Regulation Of Cell Cycle Phase Transition Regulation Of Mitotic Cell Cycle Negative Regulation Of Mitochondrial Outer Membrane Permeabilization Involved In Apoptotic Signaling Pathway Positive Regulation Of Mitotic Sister Chromatid Separation Positive Regulation Of Macrophage Differentiation Positive Regulation Of DNA Binding Positive Regulation Of Mitotic Metaphase/anaphase Transition Hepatocyte Apoptotic Process Cell Morphogenesis Involved In Neuron Differentiation Regulation Of Transcription Regulatory Region DNA Binding Negative Regulation Of Glial Cell Proliferation Negative Regulation Of Membrane Permeability Negative Regulation Of Mitochondrial Membrane Permeability Heme Biosynthetic Process Disordered Domain Specific Binding Positive Regulation Of Extracellular Matrix Organization Negative Regulation Of Epithelial Cell Apoptotic Process Regulation Of Macrophage Differentiation Regulation Of Mitochondrial Outer Membrane Permeabilization Involved In Apoptotic Signaling Pathway Tetrapyrrole Biosynthetic Process Porphyrin-containing Compound Biosynthetic Process Glial Cell Proliferation Neuron Maturation Cell Population Proliferation Regulation Of Cell Cycle Process SWI/SNF Complex Myoblast Differentiation Positive Regulation Of Chromosome Separation	Membrane Negative Regulation Of Apoptotic Process Neuregulin Receptor Activity Negative Regulation Of Programmed Cell Death Melatonin Receptor Activity Transmembrane Transport
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