TRIM35 and TRIM11

Number of citations of the paper that reports this interaction (PubMedID 22493164)
44

Data Source:
BioGRID (two hybrid)

		TRIM35	TRIM11
Description		tripartite motif containing 35	tripartite motif containing 11
Image		No pdb structure
GO Annotations	Cellular Component	Nucleus Cytoplasm	Nucleus Nucleoplasm Cytoplasm Cytosol
	Molecular Function	Protein Binding Zinc Ion Binding Transferase Activity Metal Ion Binding Ubiquitin Protein Ligase Activity	Ubiquitin-protein Transferase Activity Protein Binding Zinc Ion Binding Transferase Activity Protein Domain Specific Binding Protein-macromolecule Adaptor Activity Metal Ion Binding Ubiquitin Protein Ligase Activity
	Biological Process	Apoptotic Process Protein Ubiquitination Positive Regulation Of Apoptotic Process Suppression Of Viral Release By Host Innate Immune Response Negative Regulation Of Mitotic Cell Cycle	Regulation Of Gene Expression Protein Ubiquitination Negative Regulation Of Viral Transcription Suppression Of Viral Release By Host Innate Immune Response Negative Regulation Of DNA-templated Transcription Host-mediated Suppression Of Symbiont Invasion Positive Regulation Of Viral Entry Into Host Cell Negative Regulation Of Neurogenesis Defense Response To Virus Protein Autoubiquitination Negative Regulation Of AIM2 Inflammasome Complex Assembly
Pathways		Interferon gamma signaling	Antigen processing: Ubiquitination & Proteasome degradation
Drugs
Diseases
GWAS		Chronotype ( 30696823) Crohn's disease ( 26192919) Inflammatory bowel disease ( 26192919) Lung cancer ( 28604730)	Hip circumference (psychosocial stress interaction) ( 25271088) Non-Richardson's syndrome vs Richardson's syndrome in progressive supranuclear palsy ( 30066433)
Interacting Genes		50 interacting genes: ADIPOQ ANTXR1 BANP CABP2 COL8A1 DTX2 ENKD1 FNDC3B GNMT HNRNPA2B1 IGFN1 KANK2 LCK LMO1 MGAT5B NRF1 PAN2 PARD6B PDCD5 PHF24 PKM PPP2CA PRKAB2 PRR20A PRR20B PRR20C PRR20D PRR20E QARS1 SHC3 SMARCB1 TCEANC TRAPPC6A TRIM10 TRIM11 TRIM5 TRIM55 TRIM63 TSG101 TSSK3 UBE2D1 UBE2D2 UBE2D3 UBE2D4 UBE2K UBE2U UBE2W USP2 USP49 ZNF410	14 interacting genes: KDM5C MAPT MCL1 MECOM MED15 OGT PAX6 PHLPP1 RNF126 TRIM27 TRIM29 TRIM35 UBE2D2 USP14
Entrez ID		23087	81559
HPRD ID		15553	07429
Ensembl ID		ENSG00000104228	ENSG00000154370
Uniprot IDs		E5RGB3 Q9UPQ4	Q96F44
PDB IDs			7QS1
Enriched GO Terms of Interacting Partners?		Ubiquitin Conjugating Enzyme Activity Ubiquitin-protein Transferase Activity Post-translational Protein Modification Protein Polyubiquitination Protein Ubiquitination Protein Modification Process Protein Modification By Small Protein Conjugation Protein K48-linked Ubiquitination Ubiquitin Protein Ligase Activity Transferase Activity Host-mediated Suppression Of Symbiont Invasion Protein Metabolic Process Modification-dependent Protein Catabolic Process Ubiquitin-dependent Protein Catabolic Process Protein K11-linked Ubiquitination Host-mediated Perturbation Of Symbiont Process Macromolecule Metabolic Process Modulation Of Process Of Another Organism Protein Binding Macromolecule Catabolic Process Proteolysis Involved In Protein Catabolic Process	Negative Regulation Of Metabolic Process Suppression Of Viral Release By Host Negative Regulation Of DNA-templated Transcription Nucleus Negative Regulation Of Macromolecule Metabolic Process Chromatin Organization Negative Regulation Of RNA Biosynthetic Process Cytosol Response To Stress Regulation Of Protein Localization To Synapse Negative Regulation Of Catabolic Process Post-translational Protein Modification Ubiquitin Protein Ligase Activity Negative Regulation Of RNA Metabolic Process Apoptotic Process Cell Fate Determination Cell Death Negative Regulation Of Nucleobase-containing Compound Metabolic Process Cytoplasm Programmed Cell Death Histone-dependent DNA Binding Tubulin Complex Microtubule Lateral Binding Forebrain-midbrain Boundary Formation Pancreatic A Cell Development Protein N-acetylglucosaminyltransferase Complex Negative Regulation Of Non-canonical Inflammasome Complex Assembly Negative Regulation Of Macromolecule Biosynthetic Process Nucleoplasm Regulation Of Primary Metabolic Process Negative Regulation Of Biosynthetic Process Regulation Of Metabolic Process Protein Modification Process Negative Regulation Of Proteasomal Protein Catabolic Process Protein Ubiquitination Negative Regulation Of Ubiquitin-dependent Protein Catabolic Process Protein Polyubiquitination Innate Immune Response Transferase Activity Chromatin Remodeling Neurofibrillary Tangle Assembly Protein K63-linked Ubiquitination Protein Modification By Small Protein Conjugation Negative Regulation Of Proteolysis Involved In Protein Catabolic Process BH Domain Binding Chromatin DNA Binding Habenula Development Pallium Development Protein O-acetylglucosaminyltransferase Activity Cytoplasm Protein Quality Control By The Ubiquitin-proteasome System
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