TRIM11 and MED15

Number of citations of the paper that reports this interaction (PubMedID 16904669)
0

Data Source:
HPRD (in vivo)

		TRIM11	MED15
Description		tripartite motif containing 11	mediator complex subunit 15
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GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Cytosol	Nucleus Nucleoplasm Cytoplasm Membrane Core Mediator Complex
	Molecular Function	Ubiquitin-protein Transferase Activity Protein Binding Zinc Ion Binding Transferase Activity Protein Domain Specific Binding Protein-macromolecule Adaptor Activity Metal Ion Binding Ubiquitin Protein Ligase Activity	Transcription Coregulator Activity Protein Binding
	Biological Process	Regulation Of Gene Expression Protein Ubiquitination Negative Regulation Of Viral Transcription Suppression Of Viral Release By Host Innate Immune Response Negative Regulation Of DNA-templated Transcription Host-mediated Suppression Of Symbiont Invasion Positive Regulation Of Viral Entry Into Host Cell Negative Regulation Of Neurogenesis Defense Response To Virus Protein Autoubiquitination Negative Regulation Of AIM2 Inflammasome Complex Assembly	Regulation Of DNA-templated Transcription Positive Regulation Of Transcription Elongation By RNA Polymerase II Somatic Stem Cell Population Maintenance RNA Polymerase II Preinitiation Complex Assembly Positive Regulation Of Transcription Initiation By RNA Polymerase II
Pathways		Antigen processing: Ubiquitination & Proteasome degradation	PPARA activates gene expression Generic Transcription Pathway Transcriptional regulation of white adipocyte differentiation Transcriptional regulation of white adipocyte differentiation RSV-host interactions
Drugs
Diseases
GWAS		Hip circumference (psychosocial stress interaction) ( 25271088) Non-Richardson's syndrome vs Richardson's syndrome in progressive supranuclear palsy ( 30066433)	Lung function (FEV1/FVC) ( 30061609)
Interacting Genes		14 interacting genes: KDM5C MAPT MCL1 MECOM MED15 OGT PAX6 PHLPP1 RNF126 TRIM27 TRIM29 TRIM35 UBE2D2 USP14	13 interacting genes: ATP5F1C ATXN1 CEBPA CTDP1 FHL3 MED25 MLLT6 PLSCR1 RELA SMAD2 SMAD3 TRIM11 UBC
Entrez ID		81559	51586
HPRD ID		07429	12117
Ensembl ID		ENSG00000154370	ENSG00000099917
Uniprot IDs		Q96F44	B3KWF1 B7Z2H7 G3V1P5 Q6PKB8 Q96RN5
PDB IDs		7QS1	2GUT 7EMF 7ENA 7ENC 7ENJ 7LBM 8GXQ 8GXS 8J9A 8T9D 8TQW 8TRH
Enriched GO Terms of Interacting Partners?		Negative Regulation Of Metabolic Process Suppression Of Viral Release By Host Negative Regulation Of DNA-templated Transcription Nucleus Negative Regulation Of Macromolecule Metabolic Process Chromatin Organization Negative Regulation Of RNA Biosynthetic Process Cytosol Response To Stress Regulation Of Protein Localization To Synapse Negative Regulation Of Catabolic Process Post-translational Protein Modification Ubiquitin Protein Ligase Activity Negative Regulation Of RNA Metabolic Process Apoptotic Process Cell Fate Determination Cell Death Negative Regulation Of Nucleobase-containing Compound Metabolic Process Cytoplasm Programmed Cell Death Histone-dependent DNA Binding Tubulin Complex Microtubule Lateral Binding Forebrain-midbrain Boundary Formation Pancreatic A Cell Development Protein N-acetylglucosaminyltransferase Complex Negative Regulation Of Non-canonical Inflammasome Complex Assembly Negative Regulation Of Macromolecule Biosynthetic Process Nucleoplasm Regulation Of Primary Metabolic Process Negative Regulation Of Biosynthetic Process Regulation Of Metabolic Process Protein Modification Process Negative Regulation Of Proteasomal Protein Catabolic Process Protein Ubiquitination Negative Regulation Of Ubiquitin-dependent Protein Catabolic Process Protein Polyubiquitination Innate Immune Response Transferase Activity Chromatin Remodeling Neurofibrillary Tangle Assembly Protein K63-linked Ubiquitination Protein Modification By Small Protein Conjugation Negative Regulation Of Proteolysis Involved In Protein Catabolic Process BH Domain Binding Chromatin DNA Binding Habenula Development Pallium Development Protein O-acetylglucosaminyltransferase Activity Cytoplasm Protein Quality Control By The Ubiquitin-proteasome System	Transcription Regulator Complex Positive Regulation Of Transcription By RNA Polymerase II Paraxial Mesoderm Morphogenesis Regulation Of DNA-templated Transcription Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription DNA-binding Transcription Factor Binding Regulation Of RNA Biosynthetic Process Mesoderm Morphogenesis Pericardium Development Transcription Coactivator Binding Regulation Of Transcription By RNA Polymerase II DNA-binding Transcription Activator Activity, RNA Polymerase II-specific SMAD Protein Complex Trophoblast Cell Migration Positive Regulation Of RNA Metabolic Process Negative Regulation Of DNA-templated Transcription Regulation Of RNA Metabolic Process Negative Regulation Of RNA Biosynthetic Process Heteromeric SMAD Protein Complex Chromatin Binding Nucleobase-containing Compound Biosynthetic Process Embryonic Foregut Morphogenesis Positive Regulation Of Nucleobase-containing Compound Metabolic Process Negative Regulation Of RNA Metabolic Process Negative Regulation Of Developmental Process Regulation Of Nucleobase-containing Compound Metabolic Process Chromatin DNA Binding Nodal Signaling Pathway Co-SMAD Binding Primary MiRNA Processing Negative Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Cell Differentiation Nucleoplasm Nucleus Liver Development Osteoblast Development I-SMAD Binding Ubiquitin Protein Ligase Binding Transforming Growth Factor Beta Receptor Binding Negative Regulation Of Cell Differentiation Negative Regulation Of Multicellular Organismal Process Double-stranded DNA Binding Protein-containing Complex Positive Regulation Of Macromolecule Biosynthetic Process SMAD Protein Signal Transduction Response To Virus Response To Angiotensin R-SMAD Binding Negative Regulation Of MiRNA Transcription
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