FOXO1 and DANCR

Number of citations of the paper that reports this interaction (PubMedID 31894487)
0

Data Source:
BioGRID (unspecified method, affinity chromatography technology)

		FOXO1	DANCR
Description		forkhead box O1	differentiation antagonizing non-protein coding RNA
Image			No pdb structure
GO Annotations	Cellular Component	Chromatin Nucleus Nucleoplasm Cytoplasm Mitochondrion Cytosol
	Molecular Function	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Repressor Activity, RNA Polymerase II-specific DNA-binding Transcription Activator Activity, RNA Polymerase II-specific Nucleic Acid Binding DNA Binding Chromatin Binding DNA-binding Transcription Factor Activity Protein Binding Beta-catenin Binding Chromatin DNA Binding Ubiquitin Protein Ligase Binding Sequence-specific DNA Binding Protein Phosphatase 2A Binding Promoter-specific Chromatin Binding
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Blood Vessel Development Temperature Homeostasis Intracellular Glucose Homeostasis Gluconeogenesis Regulation Of Gluconeogenesis Regulation Of DNA-templated Transcription Regulation Of Transcription By RNA Polymerase II Protein Acetylation Autophagy Apoptotic Process DNA Damage Response Insulin Receptor Signaling Pathway Cellular Response To Starvation Gene Expression Positive Regulation Of Autophagy Cell Differentiation Response To Insulin Cellular Response To Insulin Stimulus Negative Regulation Of Stress-activated MAPK Cascade Positive Regulation Of Smooth Muscle Cell Apoptotic Process Cellular Response To Oxidative Stress Regulation Of Cell Population Proliferation Glucose Homeostasis Positive Regulation Of Apoptotic Process Negative Regulation Of Apoptotic Process Fat Cell Differentiation Negative Regulation Of Fat Cell Differentiation Positive Regulation Of Gluconeogenesis Positive Regulation Of Protein Catabolic Process Negative Regulation Of DNA-templated Transcription Positive Regulation Of DNA-templated Transcription Positive Regulation Of Transcription By RNA Polymerase II Negative Regulation Of Insulin Secretion Canonical Wnt Signaling Pathway Regulation Of Transcription Initiation By RNA Polymerase II Cellular Response To Cold Response To Fatty Acid Cellular Response To Hyperoxia Cellular Response To Nitric Oxide Negative Regulation Of Canonical Wnt Signaling Pathway Energy Homeostasis Neuronal Stem Cell Population Maintenance Negative Regulation Of Cardiac Muscle Hypertrophy In Response To Stress Regulation Of Neural Precursor Cell Proliferation Regulation Of Reactive Oxygen Species Metabolic Process
Pathways		AKT phosphorylates targets in the nucleus Regulation of gene expression in beta cells AKT-mediated inactivation of FOXO1A Constitutive Signaling by AKT1 E17K in Cancer MAPK6/MAPK4 signaling Interleukin-4 and Interleukin-13 signaling Regulation of localization of FOXO transcription factors FOXO-mediated transcription of cell death genes FOXO-mediated transcription of cell death genes FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes Regulation of FOXO transcriptional activity by acetylation Regulation of FOXO transcriptional activity by acetylation FOXO-mediated transcription of cell cycle genes FOXO-mediated transcription of cell cycle genes
Drugs
Diseases		Alveolar rhabdomyosarcoma
GWAS		Allergic disease (asthma, hay fever or eczema) ( 29083406) Arterial stiffness ( 31070453) Arterial stiffness index ( 31235810) Central corneal thickness ( 32528159 29760442 20485516 31798171 20719862) Corneal hysteresis ( 32716492 31246245 30894546) Corneal resistance factor ( 32716492 31246245 30894546) Corneal structure ( 23291589) Eosinophil count ( 27863252 32888494) Eosinophil percentage of granulocytes ( 27863252) Eosinophil percentage of white cells ( 27863252) Granulocyte percentage of myeloid white cells ( 27863252) Heel bone mineral density ( 30598549) High light scatter reticulocyte count ( 32888494) Intraocular pressure ( 29617998 29235454) Mean corpuscular hemoglobin ( 32888494 29403010 27863252) Mean corpuscular volume ( 27863252 32888494 29403010) Mean reticulocyte volume ( 32888494) Mean spheric corpuscular volume ( 32888494) Metabolite levels ( 23823483) Monocyte count ( 27863252 32888494) Monocyte percentage of white cells ( 27863252 32888494) Platelet count ( 32888494) Plateletcrit ( 32888494) Red blood cell count ( 29403010) Sum eosinophil basophil counts ( 27863252) Uterine fibroids ( 31649266 30194396) Weight ( 28552196)
Interacting Genes		40 interacting genes: AKT1 AR BCKDK CDK1 CEBPB CREBBP CSNK1G1 CTNNB1 DACH1 DANCR DYRK1A ESR1 FHL2 FOXG1 G6PC1 GSK3B HNF4A HOXA10 HOXA5 LRPPRC MDM2 MST1 NCOA1 NEDD4L PAK1 PARP1 PIK3R3 PITX1 PPARG RARA SET SFN SIRT1 SMAD3 SMAD4 SRC THRB TNS2 YWHAG YWHAZ	20 interacting genes: AP1G2 ARF5 CAV1 EZH2 FOXO1 G3BP2 GLRX3 HNRNPA1 KRT9 NCL NONO PKM PSPC1 RBM25 SERBP1 SRSF1 SYT1 TPM4 YBX1 YBX3
Entrez ID		2308	57291
HPRD ID		00645
Ensembl ID		ENSG00000150907	ENSG00000226950
Uniprot IDs		Q12778
PDB IDs		3CO6 3CO7 3COA 4LG0 5DUI 6LBI 6QVW 6QZR 6QZS 8A62 8A65
Enriched GO Terms of Interacting Partners?		Negative Regulation Of RNA Metabolic Process Negative Regulation Of Nucleobase-containing Compound Metabolic Process Negative Regulation Of Biosynthetic Process Negative Regulation Of Macromolecule Biosynthetic Process Regulation Of Transcription By RNA Polymerase II Negative Regulation Of Metabolic Process Negative Regulation Of RNA Biosynthetic Process Negative Regulation Of DNA-templated Transcription Negative Regulation Of Macromolecule Metabolic Process Response To Hormone Negative Regulation Of Transcription By RNA Polymerase II Regulation Of Nucleobase-containing Compound Metabolic Process Chromatin Binding Regulation Of RNA Metabolic Process Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of Primary Metabolic Process Cellular Response To Oxygen-containing Compound Intracellular Signal Transduction Regulation Of Macromolecule Metabolic Process Cellular Response To Hormone Stimulus Regulation Of Apoptotic Process Regulation Of Metabolic Process Regulation Of Gene Expression Positive Regulation Of Macromolecule Biosynthetic Process Regulation Of Programmed Cell Death Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Developmental Process Positive Regulation Of Biosynthetic Process Positive Regulation Of Cell Differentiation Animal Organ Development Regulation Of Protein Localization Chromatin Transcription Regulator Complex Developmental Process Positive Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Macromolecule Metabolic Process RNA Polymerase II-specific DNA-binding Transcription Factor Binding Regulation Of Developmental Process Transcription Coactivator Binding Negative Regulation Of Apoptotic Process Positive Regulation Of Nucleobase-containing Compound Metabolic Process Transcription By RNA Polymerase II Positive Regulation Of Gene Expression Negative Regulation Of Programmed Cell Death Enzyme Binding Positive Regulation Of Metabolic Process Positive Regulation Of DNA-templated Transcription Positive Regulation Of RNA Biosynthetic Process Regulation Of Cell Differentiation	Nucleic Acid Binding RNA Binding Regulation Of MRNA Metabolic Process Positive Regulation Of Cytoplasmic Translation Post-transcriptional Regulation Of Gene Expression Regulation Of MRNA Splicing, Via Spliceosome DNA Topoisomerase Binding Regulation Of Cytoplasmic Translation MRNA Binding Cellular Response To Hyperoxia Regulation Of RNA Metabolic Process Regulation Of MRNA Processing Negative Regulation Of Nucleobase-containing Compound Metabolic Process RNA Transport Regulation Of Nucleobase-containing Compound Metabolic Process Negative Regulation Of Macromolecule Metabolic Process Cellular Response To Peptide Hormone Stimulus RNA Splicing Regulation Of RNA Splicing Paraspeckles Negative Regulation Of Macromolecule Biosynthetic Process Regulation Of MRNA Stability MRNA Stabilization Regulation Of Alternative MRNA Splicing, Via Spliceosome Negative Regulation Of Metabolic Process Negative Regulation Of Biosynthetic Process Cellular Response To Increased Oxygen Levels Negative Regulation Of RNA Metabolic Process Nucleobase-containing Compound Transport Regulation Of Translation Negative Regulation Of MRNA Catabolic Process Regulation Of RNA Stability RNA Stabilization MRNA Processing Regulation Of Protein Metabolic Process Negative Regulation Of RNA Catabolic Process Response To Hyperoxia Negative Regulation Of Necroptotic Process Negative Regulation Of MRNA Metabolic Process Cellular Response To Chemical Stress Positive Regulation Of Protein Metabolic Process Negative Regulation Of Programmed Necrotic Cell Death Regulation Of Circadian Rhythm Response To Peptide Hormone Alternative MRNA Splicing, Via Spliceosome Negative Regulation Of RNA Biosynthetic Process Regulation Of The Force Of Heart Contraction Negative Regulation Of DNA-templated Transcription MRNA 3'-UTR Binding MRNA Transport
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