FOXE1 and PLCB3

Number of citations of the paper that reports this interaction (PubMedID 10748198)
0

Data Source:
HPRD (in vitro)

		FOXE1	PLCB3
Description		forkhead box E1	phospholipase C beta 3
Image		No pdb structure
GO Annotations	Cellular Component	Chromatin Nucleus	Nucleus Cytoplasm Cytosol Membrane Protein-containing Complex Postsynaptic Cytosol
	Molecular Function	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA Binding DNA-binding Transcription Factor Activity Protein Binding Sequence-specific DNA Binding Sequence-specific Double-stranded DNA Binding	Phosphatidylinositol-4,5-bisphosphate Phospholipase C Activity Phospholipase C Activity Calcium Ion Binding Protein Binding Calmodulin Binding Phosphoric Diester Hydrolase Activity Hydrolase Activity Cadherin Binding Molecular Adaptor Activity Phosphatidylinositol Phospholipase C Activity Molecular Function Activator Activity
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Regulation Of DNA-templated Transcription Regulation Of Transcription By RNA Polymerase II Thyroid Hormone Generation Anatomical Structure Morphogenesis Cell Migration Cell Differentiation Thyroid Gland Development Hair Follicle Morphogenesis Positive Regulation Of DNA-templated Transcription Animal Organ Development Thymus Development Embryonic Organ Morphogenesis System Development Roof Of Mouth Development Hard Palate Development Soft Palate Development Chordate Pharynx Development Cranial Skeletal System Development	Regulation Of Systemic Arterial Blood Pressure Lipid Metabolic Process Signal Transduction G Protein-coupled Receptor Signaling Pathway Phospholipase C-activating G Protein-coupled Receptor Signaling Pathway Phospholipase C-activating Serotonin Receptor Signaling Pathway Lipid Catabolic Process Intracellular Signal Transduction Phosphatidylinositol Metabolic Process Phosphatidylinositol-mediated Signaling Release Of Sequestered Calcium Ion Into Cytosol Adenylate Cyclase-activating G Protein-coupled CAMP Receptor Signaling Pathway
Pathways			PLC beta mediated events PLC beta mediated events Synthesis of IP3 and IP4 in the cytosol Acetylcholine regulates insulin secretion Acetylcholine regulates insulin secretion Ca2+ pathway G alpha (q) signalling events G alpha (q) signalling events G beta:gamma signalling through PLC beta Fatty Acids bound to GPR40 (FFAR1) regulate insulin secretion Fatty Acids bound to GPR40 (FFAR1) regulate insulin secretion Presynaptic function of Kainate receptors
Drugs
Diseases		Bamforth-Lazarus syndrome
GWAS		Alopecia areata ( 25608926) Alzheimer disease and age of onset ( 26830138) Autoimmune thyroid disease ( 32581359) Blond vs. brown/black hair color ( 30531825) Differentiated thyroid cancer ( 28703219) Hyperthyroidism ( 30367059) Hypothyroidism ( 30367059 27182965 22493691 21981779) Obesity-related traits ( 23251661) Papillary thyroid cancer ( 28703219) Parent of origin effect on language impairment (paternal) ( 24571439) Plasma thyroid-stimulating hormone levels ( 28333968) Serum thyroid-stimulating hormone levels ( 24852370 25436638) Thyroid cancer ( 23894154 25855579 19198613) Thyroid cancer (Papillary, radiation-related) ( 20350937) Thyroid hormone levels ( 23408906) Thyroid stimulating hormone levels ( 25743335)	Crohn's disease ( 28067908) High light scatter reticulocyte count ( 27863252 32888494) High light scatter reticulocyte percentage of red cells ( 27863252 32888494) Lymphocyte percentage of white cells ( 32888494) Mean spheric corpuscular volume ( 32888494) Red blood cell count ( 32888494) Reticulocyte count ( 32888494) Type 2 diabetes (adjusted for BMI) ( 29632382) Vitiligo ( 27723757) Waist-to-hip ratio adjusted for BMI (additive genetic model) ( 30778226)
Interacting Genes		1 interacting genes: PLCB3	13 interacting genes: CALM3 CAMK2B CAMK2G FOXE1 KRIT1 NHERF2 PARD3 PARD6A PRKG1 PRKG2 RGS12 TRPC3 TRPM7
Entrez ID		2304	5331
HPRD ID		04014	02577
Ensembl ID		ENSG00000178919	ENSG00000149782
Uniprot IDs		O00358	Q01970
PDB IDs			4GNK 4QJ3 4QJ4 4QJ5 7SQ2 8EMV 8EMW 8EMX 8UQN 8UQO
Enriched GO Terms of Interacting Partners?		Phosphatidylinositol Phospholipase C Activity Adenylate Cyclase-activating G Protein-coupled CAMP Receptor Signaling Pathway Phospholipase C-activating Serotonin Receptor Signaling Pathway Phosphatidylinositol-4,5-bisphosphate Phospholipase C Activity Phospholipase C Activity G Protein-coupled Serotonin Receptor Signaling Pathway Molecular Function Activator Activity Phosphatidylinositol-mediated Signaling Postsynaptic Cytosol Regulation Of Systemic Arterial Blood Pressure Negative Regulation Of Sequestering Of Calcium Ion Phosphoric Diester Hydrolase Activity Release Of Sequestered Calcium Ion Into Cytosol Calcium Ion Transmembrane Import Into Cytosol Phospholipase C-activating G Protein-coupled Receptor Signaling Pathway Phosphatidylinositol Metabolic Process Regulation Of Sequestering Of Calcium Ion Adenylate Cyclase-activating G Protein-coupled Receptor Signaling Pathway Calcium Ion Transmembrane Transport Calmodulin Binding Molecular Adaptor Activity Regulation Of Blood Pressure Glycerophospholipid Metabolic Process Lipid Catabolic Process Calcium Ion Transport Adenylate Cyclase-modulating G Protein-coupled Receptor Signaling Pathway Cadherin Binding Glycerolipid Metabolic Process Phospholipid Metabolic Process	Regulation Of Muscle System Process CGMP-dependent Protein Kinase Activity Type 3 Metabotropic Glutamate Receptor Binding Regulation Of System Process Protein Serine Kinase Activity Calcium- And Calmodulin-dependent Protein Kinase Complex Long-term Synaptic Potentiation Regulation Of Monoatomic Ion Transport Protein Serine/threonine Kinase Activity PAR Polarity Complex Regulation Of Calcium Ion Transport Protein Kinase Activity Regulation Of Skeletal Muscle Adaptation Regulation Of Transport Kinase Activity CGMP Binding Regulation Of Metal Ion Transport Protein Phosphorylation Calcium/calmodulin-dependent Protein Kinase Activity Apical Plasma Membrane Phosphorylation Positive Regulation Of Synaptic Transmission GTPase Regulator Activity Plasma Membrane Tight Junction Sarcoplasmic Reticulum Membrane Regulation Of Synaptic Plasticity Regulation Of Multicellular Organismal Process Localization Within Membrane Regulation Of Cellular Localization Calcium Channel Regulator Activity Establishment Or Maintenance Of Epithelial Cell Apical/basal Polarity Establishment Or Maintenance Of Apical/basal Cell Polarity Regulation Of Neuronal Synaptic Plasticity Sarcoplasmic Reticulum Negative Regulation Of High Voltage-gated Calcium Channel Activity Endocytic Vesicle Membrane Phosphatidylinositol-4,5-bisphosphate Binding Negative Regulation Of Inositol Phosphate Biosynthetic Process Negative Regulation Of Chloride Transport Type 2 Metabotropic Glutamate Receptor Binding Calcium-dependent Cell-matrix Adhesion Calcium Channel Activity Calcium-dependent Protein Serine/threonine Phosphatase Activity Chordate Pharynx Development Negative Regulation Of Monoatomic Ion Transport ATP Binding Ruffle Internode Region Of Axon Negative Regulation Of Peptidyl-threonine Phosphorylation
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