NANOS3 and IMP3

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		NANOS3	IMP3
Description		nanos C2HC-type zinc finger 3	IMP U3 small nucleolar ribonucleoprotein 3
Image		No pdb structure
GO Annotations	Cellular Component	P-body Nucleus Nucleoplasm Cytoplasm Cytosol Cytoplasmic Stress Granule Perinuclear Region Of Cytoplasm	Nucleus Nucleoplasm Nucleolus Cytosol Preribosome Small-subunit Processome Mpp10 Complex Ribonucleoprotein Complex
	Molecular Function	RNA Binding MRNA Binding Protein Binding Enzyme Activator Activity Zinc Ion Binding Metal Ion Binding	RNA Binding Protein Binding RRNA Binding SnoRNA Binding
	Biological Process	Regulation Of Translation Germ Cell Development Spermatogenesis Negative Regulation Of Translation Cell Differentiation Oogenesis Regulation Of Cell Cycle MRNA Destabilization Apoptotic Signaling Pathway Negative Regulation Of Apoptotic Signaling Pathway	RRNA Processing Maturation Of SSU-rRNA Ribosome Biogenesis Ribosomal Small Subunit Biogenesis
Pathways		Specification of primordial germ cells	rRNA modification in the nucleus and cytosol Major pathway of rRNA processing in the nucleolus and cytosol
Drugs
Diseases
GWAS		Hand grip strength ( 29691431)
Interacting Genes		7 interacting genes: CIB3 CNOT1 IMP3 MLH1 PSMB1 SIAH1 TEKT4	15 interacting genes: CCNDBP1 EFHC1 EVI5 KLC3 LPXN MPHOSPH10 NANOS3 PPP1R12C SERTAD3 SORBS3 TFIP11 TNFRSF9 USHBP1 ZNF655 ZYX
Entrez ID		342977	55272
HPRD ID		19428	12664
Ensembl ID		ENSG00000187556	ENSG00000177971
Uniprot IDs		P60323	Q9NV31
PDB IDs			2CQJ 7MQ8 7MQ9 7MQA
Enriched GO Terms of Interacting Partners?		Nuclear-transcribed MRNA Poly(A) Tail Shortening Meiotic Spindle Midzone Assembly Macromolecule Catabolic Process Meiotic Metaphase Chromosome Alignment Male Meiosis Chromosome Segregation MutLalpha Complex Chiasma Nuclear-transcribed MRNA Catabolic Process Late Recombination Nodule MRNA Catabolic Process Meiotic Metaphase I Homologous Chromosome Alignment Mpp10 Complex Positive Regulation Of Isotype Switching To IgA Isotypes RNA Catabolic Process Guanine/thymine Mispair Binding MutSalpha Complex Binding Homologous Chromosome Segregation Female Meiosis Chromosome Segregation Regulation Of Mitotic Recombination Mismatch Repair Complex Negative Regulation Of Mitotic Recombination CCR4-NOT Core Complex Negative Regulation Of Retinoic Acid Receptor Signaling Pathway Positive Regulation Of Cytoplasmic MRNA Processing Body Assembly Preribosome Meiotic Telomere Clustering Chromosome Localization To Nuclear Envelope Involved In Homologous Chromosome Segregation Armadillo Repeat Domain Binding Telomere Localization Spindle Midzone Assembly Mismatched DNA Binding Positive Regulation Of Isotype Switching To IgG Isotypes Catabolic Process Proteasome Core Complex, Beta-subunit Complex Beta-catenin Destruction Complex Positive Regulation Of Nuclear-transcribed MRNA Catabolic Process, Deadenylation-dependent Decay Poly(A)-specific Ribonuclease Activity Positive Regulation Of Nuclear-transcribed MRNA Poly(A) Tail Shortening Somatic Hypermutation Of Immunoglobulin Genes Meiotic Chromosome Segregation Somatic Diversification Of Immune Receptors Via Somatic Mutation Regulation Of Retinoic Acid Receptor Signaling Pathway Negative Regulation Of Intracellular Estrogen Receptor Signaling Pathway
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