MCF2

Description		MCF.2 cell line derived transforming sequence
Image		No pdb structure
GO Annotations	Cellular Component	Cytoplasm Cytosol Cytoskeleton Membrane
	Molecular Function	Guanyl-nucleotide Exchange Factor Activity Protein Binding
	Biological Process	Dendrite Development Intracellular Signal Transduction Negative Regulation Of Axonogenesis Regulation Of Small GTPase Mediated Signal Transduction Cellular Response To Leukemia Inhibitory Factor
Pathways		Axonal growth inhibition (RHOA activation) NRAGE signals death through JNK G alpha (12/13) signalling events RHOA GTPase cycle RHOB GTPase cycle RHOC GTPase cycle CDC42 GTPase cycle RAC1 GTPase cycle RAC2 GTPase cycle RHOG GTPase cycle RAC3 GTPase cycle
Drugs
Diseases
GWAS		Metabolite levels ( 23823483)
Novel Interacting Genes		9 novel interacting genes: ERCC3 GNA13 GNB1 RAC1 RHOA RHOG SHANK2 STUB1 TNK2
Interacting Genes		9 interacting genes: ERCC3 GNA13 GNB1 RAC1 RHOA RHOG SHANK2 STUB1 TNK2
Entrez ID		4168
HPRD ID		02406
Ensembl ID		ENSG00000101977
Uniprot IDs		B2R9S6 P10911
PDB IDs
Enriched GO Terms of Interacting Partners?		Small GTPase-mediated Signal Transduction Intracellular Signaling Cassette GTPase Activity Regulation Of Postsynapse Assembly Intracellular Signal Transduction Postsynapse Rho Protein Signal Transduction G Protein Activity Regulation Of Cell Junction Assembly Regulation Of Synapse Organization Regulation Of Vascular Associated Smooth Muscle Contraction Secretory Granule Membrane GTP Binding Positive Regulation Of Protein Modification Process Focal Adhesion Regulation Of Cell Shape Regulation Of Postsynapse Organization Establishment Or Maintenance Of Cell Polarity Nucleotide Binding Regulation Of Synapse Assembly Rac Protein Signal Transduction Cerebral Cortex Cell Migration Regulation Of Ruffle Assembly Wnt Signaling Pathway, Planar Cell Polarity Pathway Positive Regulation Of Protein-containing Complex Assembly Heterotrimeric G-protein Complex Telencephalon Cell Migration Positive Regulation Of Protein Phosphorylation Positive Regulation Of Phosphorylation Regulation Of Protein Modification Process Semaphorin-plexin Signaling Pathway Substrate Adhesion-dependent Cell Spreading Forebrain Cell Migration Membrane Invagination Cortical Cytoskeleton Organization Regulation Of Cell Morphogenesis Regulation Of Fibroblast Migration Actin Filament Organization Non-canonical Wnt Signaling Pathway Positive Regulation Of Stress Fiber Assembly Brush Border Membrane Ficolin-1-rich Granule Membrane Regulation Of Cellular Component Organization Positive Regulation Of Phosphate Metabolic Process Regulation Of Smooth Muscle Contraction Regulation Of Vasoconstriction Positive Regulation Of Actin Filament Bundle Assembly Positive Regulation Of Protein Metabolic Process Regulation Of Focal Adhesion Assembly Angiotensin-mediated Vasoconstriction Involved In Regulation Of Systemic Arterial Blood Pressure
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