SEPHS2 and PRDX6

Number of citations of the paper that reports this interaction (PubMedID 39547224)
0

Data Source:
BioGRID (pull down)

		SEPHS2	PRDX6
Description		selenophosphate synthetase 2	peroxiredoxin 6
Image		No pdb structure
GO Annotations	Cellular Component	Cytoplasm Cytosol	Extracellular Region Extracellular Space Nucleus Cytoplasm Lysosome Cytosol Membrane Azurophil Granule Lumen Perinuclear Region Of Cytoplasm Extracellular Exosome
	Molecular Function	Nucleotide Binding Selenide, Water Dikinase Activity Protein Binding ATP Binding Kinase Activity Transferase Activity Metal Ion Binding	Catalytic Activity Peroxidase Activity Glutathione Peroxidase Activity Phospholipase A2 Activity Protein Binding Antioxidant Activity Oxidoreductase Activity Transferase Activity Hydrolase Activity Ubiquitin Protein Ligase Binding Identical Protein Binding Cadherin Binding 1-acylglycerophosphocholine O-acyltransferase Activity Calcium-independent Phospholipase A2 Activity Peroxiredoxin Activity
	Biological Process	Selenium Compound Metabolic Process Selenocysteine Metabolic Process Selenocysteine Biosynthetic Process	Lipid Metabolic Process Response To Oxidative Stress Lipid Catabolic Process Hydrogen Peroxide Catabolic Process Cell Redox Homeostasis Glycerophospholipid Catabolic Process Positive Regulation Of MRNA Splicing, Via Spliceosome Cellular Oxidant Detoxification
Pathways		Selenocysteine synthesis	Detoxification of Reactive Oxygen Species Neutrophil degranulation
Drugs			2-(N-morpholino)ethanesulfonic acid Copper
Diseases
GWAS		Eosinophil count ( 32888494)	Adult body size ( 32376654) Asthma (age of onset) ( 31036433) Asthma (childhood onset) ( 31036433) Blood protein levels ( 30072576) Systemic lupus erythematosus ( 26663301) Systemic sclerosis ( 31672989)
Interacting Genes		3 interacting genes: ARHGEF5 PRDX6 SCLY	23 interacting genes: CASP10 CASP8 GPX4 GSTP1 HNF4G MAPK1 MX1 NCF2 NR4A1 ORM2 PAXIP1 PPARD PSMD8 RARA SEPHS2 SFTPA1 STH SUMO2 SUMO4 TERF1 TERF2IP UCHL5 YWHAE
Entrez ID		22928	9588
HPRD ID		12096	03817
Ensembl ID		ENSG00000179918	ENSG00000117592
Uniprot IDs		Q99611	P30041 V9HWC7
PDB IDs			1PRX 5B6M 5B6N
Enriched GO Terms of Interacting Partners?		Selenocysteine Lyase Activity Vitamin B6 Binding Selenocysteine Catabolic Process Positive Regulation Of Protein Import Myeloid Dendritic Cell Chemotaxis Regulation Of Protein Import Selenocysteine Metabolic Process 1-acylglycerophosphocholine O-acyltransferase Activity Peroxiredoxin Activity Calcium-independent Phospholipase A2 Activity Positive Regulation Of Podosome Assembly Regulation Of Podosome Assembly Positive Regulation Of JUN Kinase Activity Amino Acid Binding Dendritic Cell Migration Hematopoietic Stem Cell Homeostasis Dendritic Cell Chemotaxis Glutathione Peroxidase Activity Phospholipase A2 Activity Hydrogen Peroxide Catabolic Process Peroxidase Activity Antioxidant Activity Hydrogen Peroxide Metabolic Process Positive Regulation Of MRNA Splicing, Via Spliceosome Glycerophospholipid Catabolic Process Serine Family Amino Acid Metabolic Process Catalytic Complex Positive Regulation Of MAP Kinase Activity Podosome Phospholipid Catabolic Process Positive Regulation Of RNA Splicing Cell Redox Homeostasis	Response To Molecule Of Bacterial Origin Response To Lipopolysaccharide Nuclear Receptor Activity Positive Regulation Of Telomere Maintenance Death Effector Domain Binding Response To Stress Intracellular Receptor Signaling Pathway Positive Regulation Of Chromosome Organization Regulation Of Telomere Maintenance Response To Estradiol Ripoptosome Positive Regulation Of Metabolic Process Response To External Biotic Stimulus CD95 Death-inducing Signaling Complex Positive Regulation Of Nucleobase-containing Compound Metabolic Process Shelterin Complex Positive Regulation Of DNA Metabolic Process Positive Regulation Of Macromolecule Metabolic Process Response To Lipid Regulation Of Canonical NF-kappaB Signal Transduction Nuclear Telomere Cap Complex Nucleus G-rich Strand Telomeric DNA Binding Connective Tissue Development Telomere Capping Apoptotic Process Response To Vitamin Response To Vitamin A Programmed Cell Death Cell Death Protein Tag Activity Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Biosynthetic Process Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Chromosome Organization Regulation Of Interleukin-1 Beta Production Telomere Maintenance Positive Regulation Of Execution Phase Of Apoptosis Glutathione Peroxidase Activity Face Development Telomere Maintenance Via Telomerase Regulation Of DNA Metabolic Process Regulation Of Interleukin-1 Production Execution Phase Of Apoptosis RNA-templated DNA Biosynthetic Process Response To Ethanol Ubiquitin-like Protein Ligase Binding Regulation Of RNA Metabolic Process Negative Regulation Of MiRNA Transcription Ubiquitin Protein Ligase Binding
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