SEPHS2 and ARHGEF5

Number of citations of the paper that reports this interaction (PubMedID 21988832)
38

Data Source:
BioGRID (two hybrid)

		SEPHS2	ARHGEF5
Description		selenophosphate synthetase 2	Rho guanine nucleotide exchange factor 5
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Cytoplasm Cytosol	Podosome Nucleus Nucleoplasm Cytoplasm Cytosol Plasma Membrane Cell Projection Anchoring Junction Cell Periphery
	Molecular Function	Nucleotide Binding Selenide, Water Dikinase Activity Protein Binding ATP Binding Kinase Activity Transferase Activity Metal Ion Binding	Guanyl-nucleotide Exchange Factor Activity Protein Binding GTP Binding Lipid Binding
	Biological Process	Selenium Compound Metabolic Process Selenocysteine Metabolic Process Selenocysteine Biosynthetic Process	Myeloid Dendritic Cell Chemotaxis Actin Cytoskeleton Organization Regulation Of Actin Cytoskeleton Organization Intracellular Signal Transduction Regulation Of GTPase Activity Positive Regulation Of JUN Kinase Activity Regulation Of Small GTPase Mediated Signal Transduction Positive Regulation Of DNA-binding Transcription Factor Activity Regulation Of Cytoskeleton Organization Positive Regulation Of Stress Fiber Assembly Hematopoietic Stem Cell Homeostasis Regulation Of ERK1 And ERK2 Cascade Positive Regulation Of Podosome Assembly Positive Regulation Of Protein Import
Pathways		Selenocysteine synthesis	NRAGE signals death through JNK G alpha (12/13) signalling events RHOA GTPase cycle RHOB GTPase cycle RHOC GTPase cycle CDC42 GTPase cycle RAC1 GTPase cycle RHOG GTPase cycle
Drugs
Diseases
GWAS		Eosinophil count ( 32888494)	Breast cancer ( 23535729) Breast cancer, ovarian cancer or prostate cancer (pleiotropy) ( 27432226) Gut microbiota relative abundance (Parabacteroides) ( 33208821) Post bronchodilator FEV1/FVC ratio ( 26634245)
Interacting Genes		3 interacting genes: ARHGEF5 PRDX6 SCLY	29 interacting genes: APP ATP13A1 CALCOCO2 CCNE1 CHPF COG6 EFHC2 EPM2AIP1 FKBP8 HSF2BP HSPBAP1 LMO2 LRATD1 MB21D2 MID2 NR4A1 PICK1 PLCG1 PLEKHG4 POLR1C RHOA SEPHS2 SLAIN1 SLU7 TBC1D13 TCF4 TRIM27 TRIM54 ZRANB1
Entrez ID		22928	7984
HPRD ID		12096	02932
Ensembl ID		ENSG00000179918	ENSG00000050327
Uniprot IDs		Q99611	Q12774
PDB IDs
Enriched GO Terms of Interacting Partners?		Selenocysteine Lyase Activity Vitamin B6 Binding Selenocysteine Catabolic Process Positive Regulation Of Protein Import Myeloid Dendritic Cell Chemotaxis Regulation Of Protein Import Selenocysteine Metabolic Process 1-acylglycerophosphocholine O-acyltransferase Activity Peroxiredoxin Activity Calcium-independent Phospholipase A2 Activity Positive Regulation Of Podosome Assembly Regulation Of Podosome Assembly Positive Regulation Of JUN Kinase Activity Amino Acid Binding Dendritic Cell Migration Hematopoietic Stem Cell Homeostasis Dendritic Cell Chemotaxis Glutathione Peroxidase Activity Phospholipase A2 Activity Hydrogen Peroxide Catabolic Process Peroxidase Activity Antioxidant Activity Hydrogen Peroxide Metabolic Process Positive Regulation Of MRNA Splicing, Via Spliceosome Glycerophospholipid Catabolic Process Serine Family Amino Acid Metabolic Process Catalytic Complex Positive Regulation Of MAP Kinase Activity Podosome Phospholipid Catabolic Process Positive Regulation Of RNA Splicing Cell Redox Homeostasis	Regulation Of Supramolecular Fiber Organization Cytoplasm
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