PLA2R1 and SCN2A

		PLA2R1	SCN2A
Description		phospholipase A2 receptor 1	sodium voltage-gated channel alpha subunit 2
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GO Annotations	Cellular Component	Extracellular Region Plasma Membrane Cell Surface Membrane Receptor Complex	Voltage-gated Sodium Channel Complex Plasma Membrane Membrane Axon Node Of Ranvier Monoatomic Ion Channel Complex
	Molecular Function	Phospholipase A2 Inhibitor Activity Carbohydrate Binding Signaling Receptor Activity Phospholipase Binding	Monoatomic Ion Channel Activity Voltage-gated Sodium Channel Activity Monoatomic Cation Channel Activity Sodium Channel Activity Protein Binding Calmodulin Binding
	Biological Process	Positive Regulation Of Cytokine Production Endocytosis Receptor-mediated Endocytosis Positive Regulation Of DNA Damage Response, Signal Transduction By P53 Class Mediator Reactive Oxygen Species Metabolic Process Positive Regulation Of Arachidonate Secretion Replicative Senescence Oxidative Stress-induced Premature Senescence Negative Regulation Of Arachidonate Secretion Positive Regulation Of Podocyte Apoptotic Process	Action Potential Monoatomic Ion Transport Sodium Ion Transport Nervous System Development Memory Intrinsic Apoptotic Signaling Pathway In Response To Osmotic Stress Neuronal Action Potential Monoatomic Ion Transmembrane Transport Sodium Ion Transmembrane Transport Myelination Neuron Apoptotic Process Transmembrane Transport Cellular Response To Hypoxia Cardiac Muscle Cell Action Potential Involved In Contraction
Pathways		Acyl chain remodelling of PC Acyl chain remodelling of PS Acyl chain remodelling of PE Acyl chain remodelling of PI Acyl chain remodelling of PG Synthesis of PA	Interaction between L1 and Ankyrins Phase 0 - rapid depolarisation Sensory perception of sweet, bitter, and umami (glutamate) taste
Drugs			Tramadol Ranolazine Phenytoin Topiramate Valproic acid Lamotrigine Carbamazepine Oxcarbazepine Propofol Cocaine Zonisamide Promethazine Chloroprocaine Tetrodotoxin Brivaracetam Tetracaine Amylocaine Propoxycaine Pramocaine Pentoxyverine Dichlorobenzyl alcohol Metergoline Bioallethrin Amylmetacresol Fish oil
Diseases			Early infantile epileptic encephalopathy; Ohtahara syndrome
GWAS		Bilirubin levels ( 20639394) Blood protein levels ( 30072576) Crohn's disease ( 26192919) Idiopathic membranous nephropathy ( 21323541) Inflammatory bowel disease ( 26192919) Membranous nephropathy ( 27333618 32231244) Platelet count ( 32888494) Plateletcrit ( 32888494) Proportion of activated microglia (inferior temporal cortex) ( 30679421) Refractive error ( 32231278) Tourette syndrome ( 30818990) Waist-hip index ( 34021172) Waist-to-hip ratio adjusted for BMI ( 34021172)	Adult body size ( 32376654) Age at first birth ( 34211149) Age at first sexual intercourse ( 34211149) Bipolar disorder ( 34002096 33263727 31043756) Diastolic blood pressure ( 30224653) Epilepsy ( 30531953) Factor VII activity ( 30642921) Febrile seizures ( 25344690) Febrile seizures (MMR vaccine-related) ( 25344690) Febrile seizures (MMR vaccine-unrelated) ( 25344690) Focal epilepsy ( 30531953) Generalized epilepsy ( 30531953) Periodontitis (DPAL) ( 24024966) Refractive error ( 32231278) Trunk fat mass ( 28552196) Urinary sodium excretion ( 31409800)
Interacting Genes		3 interacting genes: PLA2G10 PLA2G2A SCN2A	10 interacting genes: ANK3 ARHGEF10L B4GAT1 BAZ2B GALNT13 MPP3 PKP4 PLA2R1 RNF130 SCN4B
Entrez ID		22925	6326
HPRD ID		09222	03133
Ensembl ID		ENSG00000153246	ENSG00000136531
Uniprot IDs		B7ZML4 Q13018	Q99250
PDB IDs		6JLI 7QSR	2KAV 4JPZ 4RLY 6BUT 6J8E
Enriched GO Terms of Interacting Partners?		Intestinal Stem Cell Homeostasis Positive Regulation Of Macrophage Derived Foam Cell Differentiation Low-density Lipoprotein Particle Remodeling Calcium-dependent Phospholipase A2 Activity Arachidonate Secretion Phospholipase A2 Activity Phosphatidylglycerol Metabolic Process Phosphatidylethanolamine Metabolic Process Phosphatidic Acid Metabolic Process Regulation Of Macrophage Derived Foam Cell Differentiation Plasma Lipoprotein Particle Remodeling Protein-containing Complex Remodeling Long-chain Fatty Acid Transport Phosphatidylcholine Metabolic Process Fatty Acid Transport Phospholipid Binding Monocarboxylic Acid Transport Homeostasis Of Number Of Cells Platelet Activating Factor Catabolic Process Intrinsic Apoptotic Signaling Pathway In Response To Osmotic Stress Lysophospholipid Transport Carboxylic Acid Transport Organic Acid Transport Glycerophospholipid Metabolic Process Lipid Catabolic Process Positive Regulation Of Arachidonate Secretion Lipid Transport Glycerolipid Metabolic Process Regulation Of Arachidonate Secretion Phospholipid Metabolic Process Organic Anion Transport 1-alkyl-2-acetylglycerophosphocholine Esterase Activity Platelet Activating Factor Metabolic Process Positive Regulation Of Acrosome Reaction Regulation Of Inflammatory Response Regulation Of Neutrophil Activation Voltage-gated Sodium Channel Complex Phosphatidylcholine Catabolic Process Positive Regulation Of Prostaglandin Secretion Production Of Molecular Mediator Involved In Inflammatory Response Multicellular Organismal-level Homeostasis Regulation Of Acrosome Reaction Negative Regulation Of Cholesterol Efflux Secretion Prostaglandin Biosynthetic Process Voltage-gated Sodium Channel Activity Positive Regulation Of Icosanoid Secretion Angiotensin-activated Signaling Pathway Calcium Ion Binding Node Of Ranvier	Sodium Channel Regulator Activity Organelle Neuronal Action Potential Positive Regulation Of Sodium Ion Transport Intercalated Disc Positive Regulation Of Membrane Depolarization During Cardiac Muscle Cell Action Potential Regulation Of Sodium Ion Transport Maintenance Of Protein Location In Plasma Membrane Positive Regulation Of Podocyte Apoptotic Process Negative Regulation Of Arachidonate Secretion Positive Regulation Of Cell Communication By Electrical Coupling Action Potential Negative Regulation Of Icosanoid Secretion Oxidative Stress-induced Premature Senescence Transmembrane Transporter Binding Regulation Of Delayed Rectifier Potassium Channel Activity Negative Regulation Of Potassium Ion Transmembrane Transporter Activity Spectrin-associated Cytoskeleton Channel Activator Activity Regulation Of Membrane Depolarization During Action Potential Negative Regulation Of Voltage-gated Potassium Channel Activity Cellular Response To Magnesium Ion Regulation Of Membrane Depolarization During Cardiac Muscle Cell Action Potential Negative Regulation Of Delayed Rectifier Potassium Channel Activity Positive Regulation Of Monoatomic Ion Transport Adherens Junction Voltage-gated Sodium Channel Activity Involved In Cardiac Muscle Cell Action Potential AV Node Cell Action Potential Protein O-linked Glycosylation Protein Glycosylation Glycosyltransferase Activity Poly-N-acetyllactosamine Metabolic Process Glycosylation N-acetyllactosaminide Beta-1,3-N-acetylglucosaminyltransferase Activity Poly-N-acetyllactosamine Biosynthetic Process Macromolecule Glycosylation Carbohydrate Binding Regulation Of Arachidonate Secretion Stress-induced Premature Senescence Phospholipase A2 Inhibitor Activity Positive Regulation Of Arachidonate Secretion Negative Regulation Of Fatty Acid Transport Cellular Response To Sterol Depletion SREBP Signaling Pathway
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