PLA2R1

Description		phospholipase A2 receptor 1
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GO Annotations	Cellular Component	Extracellular Region Plasma Membrane Cell Surface Membrane Receptor Complex
	Molecular Function	Phospholipase A2 Inhibitor Activity Carbohydrate Binding Signaling Receptor Activity Phospholipase Binding
	Biological Process	Positive Regulation Of Cytokine Production Endocytosis Receptor-mediated Endocytosis Positive Regulation Of DNA Damage Response, Signal Transduction By P53 Class Mediator Reactive Oxygen Species Metabolic Process Positive Regulation Of Arachidonate Secretion Replicative Senescence Oxidative Stress-induced Premature Senescence Negative Regulation Of Arachidonate Secretion Positive Regulation Of Podocyte Apoptotic Process
Pathways		Acyl chain remodelling of PC Acyl chain remodelling of PS Acyl chain remodelling of PE Acyl chain remodelling of PI Acyl chain remodelling of PG Synthesis of PA
Drugs
Diseases
GWAS		Bilirubin levels ( 20639394) Blood protein levels ( 30072576) Crohn's disease ( 26192919) Idiopathic membranous nephropathy ( 21323541) Inflammatory bowel disease ( 26192919) Membranous nephropathy ( 27333618 32231244) Platelet count ( 32888494) Plateletcrit ( 32888494) Proportion of activated microglia (inferior temporal cortex) ( 30679421) Refractive error ( 32231278) Tourette syndrome ( 30818990) Waist-hip index ( 34021172) Waist-to-hip ratio adjusted for BMI ( 34021172)
Novel Interacting Genes		3 novel interacting genes: PLA2G10 PLA2G2A SCN2A
Interacting Genes		3 interacting genes: PLA2G10 PLA2G2A SCN2A
Entrez ID		22925
HPRD ID		09222
Ensembl ID		ENSG00000153246
Uniprot IDs		B7ZML4 Q13018
PDB IDs		6JLI 7QSR
Enriched GO Terms of Interacting Partners?		Intestinal Stem Cell Homeostasis Positive Regulation Of Macrophage Derived Foam Cell Differentiation Low-density Lipoprotein Particle Remodeling Calcium-dependent Phospholipase A2 Activity Arachidonate Secretion Phospholipase A2 Activity Phosphatidylglycerol Metabolic Process Phosphatidylethanolamine Metabolic Process Phosphatidic Acid Metabolic Process Regulation Of Macrophage Derived Foam Cell Differentiation Plasma Lipoprotein Particle Remodeling Protein-containing Complex Remodeling Long-chain Fatty Acid Transport Phosphatidylcholine Metabolic Process Fatty Acid Transport Phospholipid Binding Monocarboxylic Acid Transport Homeostasis Of Number Of Cells Platelet Activating Factor Catabolic Process Intrinsic Apoptotic Signaling Pathway In Response To Osmotic Stress Lysophospholipid Transport Carboxylic Acid Transport Organic Acid Transport Glycerophospholipid Metabolic Process Lipid Catabolic Process Positive Regulation Of Arachidonate Secretion Lipid Transport Glycerolipid Metabolic Process Regulation Of Arachidonate Secretion Phospholipid Metabolic Process Organic Anion Transport 1-alkyl-2-acetylglycerophosphocholine Esterase Activity Platelet Activating Factor Metabolic Process Positive Regulation Of Acrosome Reaction Regulation Of Inflammatory Response Regulation Of Neutrophil Activation Voltage-gated Sodium Channel Complex Phosphatidylcholine Catabolic Process Positive Regulation Of Prostaglandin Secretion Production Of Molecular Mediator Involved In Inflammatory Response Multicellular Organismal-level Homeostasis Regulation Of Acrosome Reaction Negative Regulation Of Cholesterol Efflux Secretion Prostaglandin Biosynthetic Process Voltage-gated Sodium Channel Activity Positive Regulation Of Icosanoid Secretion Angiotensin-activated Signaling Pathway Calcium Ion Binding Node Of Ranvier
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