CNKSR2 and RGS3

Number of citations of the paper that reports this interaction (PubMedID 16637659)
54

Data Source:
HPRD (in vitro)

		CNKSR2	RGS3
Description		connector enhancer of kinase suppressor of Ras 2	regulator of G protein signaling 3
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GO Annotations	Cellular Component	Cytoplasm Plasma Membrane Postsynaptic Density Membrane Neuronal Cell Body Postsynaptic Membrane Extracellular Exosome Glutamatergic Synapse Extrinsic Component Of Postsynaptic Density Membrane	Nucleus Cytoplasm Cytosol Plasma Membrane Membrane
	Molecular Function	Protein Binding Protein Kinase Binding Identical Protein Binding	GTPase Activity GTPase Activator Activity Protein Binding
	Biological Process	Regulation Of Signal Transduction Intracellular Signal Transduction Postsynaptic Specialization Organization Postsynapse Organization	G Protein-coupled Receptor Signaling Pathway Regulation Of G Protein-coupled Receptor Signaling Pathway Negative Regulation Of Signal Transduction
Pathways		MAP2K and MAPK activation Signaling by moderate kinase activity BRAF mutants Signaling by high-kinase activity BRAF mutants Signaling by BRAF and RAF1 fusions Paradoxical activation of RAF signaling by kinase inactive BRAF Signaling downstream of RAS mutants Signaling by RAF1 mutants	G alpha (q) signalling events G alpha (i) signalling events
Drugs
Diseases
GWAS		Bipolar disorder ( 31043756) Educational attainment (years of education) ( 30038396) Schizophrenia ( 25056061) Type 2 diabetes ( 30718926)	Height ( 28552196) Hematocrit ( 32888494) Hemoglobin ( 32888494) Hemoglobin levels ( 32327693) Red blood cell count ( 32888494) Refractive error ( 32231278)
Interacting Genes		14 interacting genes: DLG1 DLG2 DLG3 DLG4 LRRC7 PATJ RALA RGS3 SHANK3 SMURF2 SNTA1 TJP1 TNIK YAP1	25 interacting genes: ACD APP CDK6 CNKSR2 CYSRT1 DEPDC1B EFNB1 EFNB2 ESR1 GLS2 GNA11 GNAI3 GORASP2 GRIN2A HES4 HIPK3 MAPK12 PAX6 PLSCR1 PRKN SCN5A YWHAB YWHAE YWHAQ YWHAZ
Entrez ID		22866	5998
HPRD ID		06473	03720
Ensembl ID		ENSG00000149970	ENSG00000138835
Uniprot IDs		A0A2R8Y622 A0A2R8Y700 A0A2R8Y7A1 A0A2U3TZH5 B3KPN2 Q8WXI2	A0A087WUY2 A0A8Q3WKG2 B3KVT7 B3KWG8 H7BXY1 P49796 Q53GP3
PDB IDs		2EAN 3BS5	2F5Y 2OJ4 3FBK
Enriched GO Terms of Interacting Partners?		Receptor Clustering Establishment Or Maintenance Of Apical/basal Cell Polarity Establishment Or Maintenance Of Epithelial Cell Apical/basal Polarity Ionotropic Glutamate Receptor Binding Protein Localization To Cell Junction Receptor Localization To Synapse Protein Localization To Synapse Establishment Or Maintenance Of Cell Polarity Regulation Of Postsynaptic Membrane Neurotransmitter Receptor Levels Neuromuscular Junction Adherens Junction Bicellular Tight Junction Localization Within Membrane Protein Localization To Membrane Cell Junction Basolateral Plasma Membrane Postsynaptic Density Kinase Binding Postsynaptic Density Membrane Cell-cell Adhesion Protein Localization To Postsynaptic Membrane Protein Localization To Postsynapse Neuron Projection Plasma Membrane AMPA Glutamate Receptor Clustering Regulation Of Cell Projection Organization Anchoring Junction Neuron Spine Synaptic Membrane Protein Kinase Binding Protein-containing Complex Localization GMP Kinase Activity Regulation Of Anatomical Structure Morphogenesis Ribonucleoside Diphosphate Metabolic Process Cell Adhesion GDP Metabolic Process Nucleoside Diphosphate Metabolic Process Regulation Of Biological Quality Cytosol Juxtaparanode Region Of Axon Neurotransmitter-gated Ion Channel Clustering Cell Junction Assembly Cellular Response To Potassium Ion Nervous System Development Cellular Localization Chemical Synaptic Transmission Dendritic Spine Morphogenesis Postsynaptic Density Organization Neurotransmitter Receptor Localization To Postsynaptic Specialization Membrane Regulation Of Plasma Membrane Bounded Cell Projection Organization	Phosphoserine Residue Binding Enzyme Binding G Protein-coupled Receptor Binding Ephrin Receptor Binding Regulation Of Endoplasmic Reticulum Stress-induced Neuron Intrinsic Apoptotic Signaling Pathway Developmental Process Protein Domain Specific Binding Regulation Of Spontaneous Synaptic Transmission Regulation Of Toll-like Receptor Signaling Pathway Regulation Of Membrane Potential Ligand-gated Ion Channel Signaling Pathway Protein Sequestering Activity Signal Transduction Regulation Of Transport Protein Kinase Binding Negative Regulation Of Protein Localization To Nucleus Transmembrane Transporter Binding Modulation Of Excitatory Postsynaptic Potential Regulation Of Monoatomic Ion Transmembrane Transport Peptidase Activator Activity System Development Cellular Response To Manganese Ion Extracellular Exosome Ubiquitin Protein Ligase Binding Regulation Of Establishment Of Protein Localization Glutamatergic Synapse Regulation Of MiRNA Transcription Response To Manganese Ion Negative Regulation Of Nucleobase-containing Compound Metabolic Process Protein Targeting Regulation Of Protein Localization Negative Regulation Of Protein Localization Response To Lead Ion Negative Regulation Of RNA Biosynthetic Process Regulation Of Monoatomic Ion Transport Regulation Of MiRNA Metabolic Process Negative Regulation Of DNA-templated Transcription Cellular Response To Catecholamine Stimulus Regulation Of Protein Transport Regulation Of Neurotransmitter Uptake Response To Catecholamine Focal Adhesion Guanyl Nucleotide Binding Startle Response Negative Regulation Of Transport Regulation Of Innate Immune Response Positive Regulation Of Protein Transport Melanosome Negative Regulation Of Macromolecule Metabolic Process G-protein Beta/gamma-subunit Complex Binding
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