CNKSR2

Description		connector enhancer of kinase suppressor of Ras 2
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GO Annotations	Cellular Component	Cytoplasm Plasma Membrane Postsynaptic Density Membrane Neuronal Cell Body Postsynaptic Membrane Extracellular Exosome Glutamatergic Synapse Extrinsic Component Of Postsynaptic Density Membrane
	Molecular Function	Protein Binding Protein Kinase Binding Identical Protein Binding
	Biological Process	Regulation Of Signal Transduction Intracellular Signal Transduction Postsynaptic Specialization Organization Postsynapse Organization
Pathways		MAP2K and MAPK activation Signaling by moderate kinase activity BRAF mutants Signaling by high-kinase activity BRAF mutants Signaling by BRAF and RAF1 fusions Paradoxical activation of RAF signaling by kinase inactive BRAF Signaling downstream of RAS mutants Signaling by RAF1 mutants
Drugs
Diseases
GWAS		Bipolar disorder ( 31043756) Educational attainment (years of education) ( 30038396) Schizophrenia ( 25056061) Type 2 diabetes ( 30718926)
Novel Interacting Genes		14 novel interacting genes: DLG1 DLG2 DLG3 DLG4 LRRC7 PATJ RALA RGS3 SHANK3 SMURF2 SNTA1 TJP1 TNIK YAP1
Interacting Genes		14 interacting genes: DLG1 DLG2 DLG3 DLG4 LRRC7 PATJ RALA RGS3 SHANK3 SMURF2 SNTA1 TJP1 TNIK YAP1
Entrez ID		22866
HPRD ID		06473
Ensembl ID		ENSG00000149970
Uniprot IDs		A0A2R8Y622 A0A2R8Y700 A0A2R8Y7A1 A0A2U3TZH5 B3KPN2 Q8WXI2
PDB IDs		2EAN 3BS5
Enriched GO Terms of Interacting Partners?		Receptor Clustering Establishment Or Maintenance Of Apical/basal Cell Polarity Establishment Or Maintenance Of Epithelial Cell Apical/basal Polarity Ionotropic Glutamate Receptor Binding Protein Localization To Cell Junction Receptor Localization To Synapse Protein Localization To Synapse Establishment Or Maintenance Of Cell Polarity Regulation Of Postsynaptic Membrane Neurotransmitter Receptor Levels Neuromuscular Junction Adherens Junction Bicellular Tight Junction Localization Within Membrane Protein Localization To Membrane Cell Junction Basolateral Plasma Membrane Postsynaptic Density Kinase Binding Postsynaptic Density Membrane Cell-cell Adhesion Protein Localization To Postsynaptic Membrane Protein Localization To Postsynapse Neuron Projection Plasma Membrane AMPA Glutamate Receptor Clustering Regulation Of Cell Projection Organization Anchoring Junction Neuron Spine Synaptic Membrane Protein Kinase Binding Protein-containing Complex Localization GMP Kinase Activity Regulation Of Anatomical Structure Morphogenesis Ribonucleoside Diphosphate Metabolic Process Cell Adhesion GDP Metabolic Process Nucleoside Diphosphate Metabolic Process Regulation Of Biological Quality Cytosol Juxtaparanode Region Of Axon Neurotransmitter-gated Ion Channel Clustering Cell Junction Assembly Cellular Response To Potassium Ion Nervous System Development Cellular Localization Chemical Synaptic Transmission Dendritic Spine Morphogenesis Postsynaptic Density Organization Neurotransmitter Receptor Localization To Postsynaptic Specialization Membrane Regulation Of Plasma Membrane Bounded Cell Projection Organization
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