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CNKSR2

Description connector enhancer of kinase suppressor of Ras 2
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GO Annotations Cellular Component
  • Cytoplasm
  • Plasma Membrane
  • Neuron Projection
  • Neuronal Cell Body
  • Extracellular Exosome
  • Glutamatergic Synapse
  • Extrinsic Component Of Postsynaptic Density Membrane
Molecular Function
  • Protein Binding
  • Protein Kinase Binding
  • Identical Protein Binding
Biological Process
  • Regulation Of Signal Transduction
  • Intracellular Signal Transduction
  • Postsynapse Organization
Pathways
  • MAP2K and MAPK activation
  • Signaling by moderate kinase activity BRAF mutants
  • Signaling by high-kinase activity BRAF mutants
  • Signaling by BRAF and RAF fusions
  • Paradoxical activation of RAF signaling by kinase inactive BRAF
  • Signaling downstream of RAS mutants
  • Signaling by RAF1 mutants
Drugs
Diseases
GWAS
  • Bipolar disorder ( 31043756)
  • Educational attainment (years of education) ( 30038396)
  • Schizophrenia ( 25056061)
  • Type 2 diabetes ( 30718926)
Interacting Genes 13 interacting genes: DLG1 DLG2 DLG3 DLG4 LRRC7 PATJ RALA RGS3 SHANK3 SMURF2 SNTA1 TJP1 TNIK
Entrez ID 22866
HPRD ID 06473
Ensembl ID ENSG00000149970
Uniprot IDs A0A2R8Y622 A0A2R8Y700 A0A2R8Y7A1 A0A2U3TZH5 B3KPN2 Q8WXI2
PDB IDs 2EAN 3BS5
Enriched GO Terms of Interacting Partners?
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© Madhavi K. Ganapathiraju 2012-2025