PPM1E and CCL19

		PPM1E	CCL19
Description		protein phosphatase, Mg2+/Mn2+ dependent 1E	C-C motif chemokine ligand 19
Image		No pdb structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm Nucleolus Cytoplasm Protein-containing Complex	Extracellular Region Extracellular Space
	Molecular Function	Phosphoprotein Phosphatase Activity Protein Serine/threonine Phosphatase Activity Protein Binding Hydrolase Activity Cation Binding Metal Ion Binding	Cytokine Activity Protein Binding Chemokine Activity CCR7 Chemokine Receptor Binding CCR10 Chemokine Receptor Binding Chemokine Receptor Binding CCR Chemokine Receptor Binding
	Biological Process	Negative Regulation Of Protein Kinase Activity Signal Transduction Peptidyl-threonine Dephosphorylation Positive Regulation Of Stress Fiber Assembly Cellular Response To Lipopolysaccharide Cellular Response To Xenobiotic Stimulus	Establishment Of T Cell Polarity Immunological Synapse Formation Dendritic Cell Chemotaxis Myeloid Dendritic Cell Chemotaxis Positive Regulation Of Dendritic Cell Antigen Processing And Presentation Intracellular Calcium Ion Homeostasis Chemotaxis Inflammatory Response Immune Response Cell Communication Response To Virus Positive Regulation Of Glycoprotein Biosynthetic Process Positive Regulation Of Cell Migration T Cell Costimulation Killing Of Cells Of Another Organism Regulation Of Cdc42 Protein Signal Transduction Positive Regulation Of Interleukin-1 Beta Production Positive Regulation Of Interleukin-12 Production Positive Regulation Of Tumor Necrosis Factor Production Positive Regulation Of Rac Protein Signal Transduction CCL19-activated CCR7 Signaling Pathway Positive Regulation Of T Cell Proliferation Positive Regulation Of Canonical NF-kappaB Signal Transduction Positive Regulation Of T-helper 1 Cell Differentiation Positive Regulation Of Endocytosis Positive Regulation Of JNK Cascade Eosinophil Chemotaxis Positive Regulation Of Receptor-mediated Endocytosis Cell Maturation Positive Regulation Of Chemotaxis Release Of Sequestered Calcium Ion Into Cytosol Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Regulation Of Cell Projection Assembly Antimicrobial Humoral Immune Response Mediated By Antimicrobial Peptide Chemokine-mediated Signaling Pathway Positive Regulation Of ERK1 And ERK2 Cascade Cellular Response To Prostaglandin E Stimulus Response To Nitric Oxide Positive Regulation Of Neutrophil Chemotaxis Mature Conventional Dendritic Cell Differentiation Cellular Response To Virus Positive Regulation Of Phospholipase C/protein Kinase C Signal Transduction Positive Regulation Of Non-canonical NF-kappaB Signal Transduction Positive Regulation Of Cell Motility Positive Regulation Of Dendritic Cell Dendrite Assembly Negative Regulation Of Dendritic Cell Apoptotic Process
Pathways		Negative regulation of NMDA receptor-mediated neuronal transmission	Chemokine receptors bind chemokines G alpha (i) signalling events Interleukin-10 signaling
Drugs
Diseases
GWAS		Circulating myeloperoxidase levels (plasma) ( 23620142) Cognitive function ( 25644384) Cognitive test performance ( 17903297) Intelligence (MTAG) ( 29326435) Post bronchodilator FEV1/FVC ratio ( 26634245) Refractive error ( 32231278) Systolic blood pressure ( 30224653 30578418) Testicular germ cell tumor ( 23666239)	Metabolite levels ( 23823483) Rheumatoid arthritis ( 24390342 30423114)
Interacting Genes		6 interacting genes: ARHGEF7 CCL19 DISC1 GAPDH PRKAA1 TNIK	18 interacting genes: ACKR2 ACKR4 ATP6V0B B4GALT1 CCL22 CCR10 CCR7 CNTFR CXCL13 DCTN3 FZD7 GALT MEOX2 PAX5 PF4V1 PPM1E RPS4X TLN1
Entrez ID		22843	6363
HPRD ID		17888	03750
Ensembl ID		ENSG00000175175	ENSG00000172724
Uniprot IDs		Q8WY54	Q6IBD6 Q99731
PDB IDs			2MP1 7STA
Enriched GO Terms of Interacting Partners?		Positive Regulation Of Cell Projection Organization Positive Regulation Of Cellular Component Organization Positive Regulation Of Cell Adhesion Positive Regulation Of Signal Transduction Response To Prostaglandin E Cellular Response To Prostaglandin E Stimulus Cellular Response To Prostaglandin Stimulus Regulation Of Plasma Membrane Bounded Cell Projection Organization Regulation Of Cell Projection Organization Positive Regulation Of Cell Communication Positive Regulation Of Signaling Regulation Of Cell Adhesion Wnt Signaling Pathway Cell Surface Receptor Signaling Pathway Neuron Cellular Homeostasis Positive Regulation Of Intracellular Signal Transduction Organelle Organization Regulation Of Cellular Component Organization TOR Signaling Regulation Of Developmental Process Negative Regulation Of Glucosylceramide Biosynthetic Process Positive Regulation Of Dendritic Cell Dendrite Assembly Negative Regulation Of Microtubule Nucleation Positive Regulation Of Developmental Process Antimicrobial Humoral Immune Response Mediated By Antimicrobial Peptide Peptidyl-cysteine S-trans-nitrosylation Glyceraldehyde-3-phosphate Dehydrogenase (NAD+) (phosphorylating) Activity Histone H2BS36 Kinase Activity [hydroxymethylglutaryl-CoA Reductase (NADPH)] Kinase Activity Intracellular Chemical Homeostasis Positive Regulation Of Plasma Membrane Bounded Cell Projection Assembly Positive Regulation Of JNK Cascade CCR7 Chemokine Receptor Binding CCL19-activated CCR7 Signaling Pathway Nervous System Development Glucose Metabolic Process Killing Of Cells Of Another Organism Regulation Of Protein Metabolic Process Positive Regulation Of Cell-substrate Adhesion Regulation Of Signal Transduction Peptidyl-cysteine S-nitrosylase Activity Cold Acclimation Positive Regulation Of Mitochondrial Transcription Cellular Homeostasis Myeloid Dendritic Cell Chemotaxis Regulation Of Dendritic Cell Dendrite Assembly CCR10 Chemokine Receptor Binding Pyramidal Neuron Migration To Cerebral Cortex Central Region Of Growth Cone Regulation Of JNK Cascade	Chemokine-mediated Signaling Pathway Cell Chemotaxis C-C Chemokine Receptor Activity Chemokine Receptor Activity Chemotaxis Locomotion Cytokine-mediated Signaling Pathway Myeloid Leukocyte Migration Positive Regulation Of Cytosolic Calcium Ion Concentration External Side Of Plasma Membrane Cell Migration C-C Chemokine Binding Leukocyte Migration Immune System Process Cell Motility G Protein-coupled Receptor Signaling Pathway Leukocyte Chemotaxis Inflammatory Response Chemokine Activity Calcium-mediated Signaling G Protein-coupled Receptor Activity Galactose Metabolic Process Positive Regulation Of Epithelial Cell Proliferation Involved In Wound Healing Granulocyte Chemotaxis Cell Surface Receptor Signaling Pathway CXCR Chemokine Receptor Binding Cellular Response To Lipid Granulocyte Migration Immune Response Mononuclear Cell Migration Response To Lipopolysaccharide Antimicrobial Humoral Immune Response Mediated By Antimicrobial Peptide Response To Molecule Of Bacterial Origin Antimicrobial Humoral Response C-C Motif Chemokine 19 Receptor Activity Chemokine (C-C Motif) Ligand 19 Binding Positive Regulation Of Glycoprotein Biosynthetic Process Involved In Immunological Synapse Formation Chemokine (C-C Motif) Ligand 21 Binding C-C Motif Chemokine 21 Receptor Activity UDP-glucose:hexose-1-phosphate Uridylyltransferase Activity Positive Regulation Of Circulating Fibrinogen Levels Cellular Response To Molecule Of Bacterial Origin Cellular Response To Lipopolysaccharide Negative Regulation Of Ectodermal Cell Fate Specification CXCR5 Chemokine Receptor Binding Lymphocyte Chemotaxis Across High Endothelial Venule Endothelial Cell Chemotaxis To Fibroblast Growth Factor Response To Lipid Regulation Of Humoral Immune Response Signal Transduction
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