COPG1 and PTGES3

Number of citations of the paper that reports this interaction (PubMedID 11056392)
0

Data Source:
HPRD (in vitro, in vivo)

		COPG1	PTGES3
Description		coat protein complex I subunit gamma 1	prostaglandin E synthase 3
Image
GO Annotations	Cellular Component	Golgi Membrane Cytoplasm Endoplasmic Reticulum Endoplasmic Reticulum Membrane Endoplasmic Reticulum-Golgi Intermediate Compartment Golgi Apparatus Cytosol Membrane Membrane Coat COPI Vesicle Coat Transport Vesicle COPI-coated Vesicle Membrane Organelle Membrane Cytoplasmic Vesicle	Chromosome, Telomeric Region Nucleus Nucleoplasm Telomerase Holoenzyme Complex Cytoplasm Cytosol Protein-containing Complex Protein Folding Chaperone Complex
	Molecular Function	Structural Molecule Activity Protein Binding	Telomerase Activity Protein Binding Isomerase Activity Prostaglandin-E Synthase Activity Unfolded Protein Binding Protein-folding Chaperone Binding Hsp90 Protein Binding DNA Polymerase Binding
	Biological Process	Intracellular Protein Transport Endoplasmic Reticulum To Golgi Vesicle-mediated Transport Intra-Golgi Vesicle-mediated Transport Protein Secretion Protein Transport Vesicle-mediated Transport Establishment Of Golgi Localization Organelle Transport Along Microtubule	Telomere Maintenance Prostaglandin Biosynthetic Process Protein Folding Lipid Metabolic Process Fatty Acid Metabolic Process Fatty Acid Biosynthetic Process Prostaglandin Metabolic Process Telomere Maintenance Via Telomerase Signal Transduction Positive Regulation Of Telomere Maintenance Via Telomerase Prostanoid Biosynthetic Process Protein Stabilization Chaperone-mediated Protein Complex Assembly Telomerase Holoenzyme Complex Assembly
Pathways		COPI-mediated anterograde transport COPI-dependent Golgi-to-ER retrograde traffic	Synthesis of Prostaglandins (PG) and Thromboxanes (TX) HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand HSF1 activation Attenuation phase Aryl hydrocarbon receptor signalling ESR-mediated signaling Estrogen-dependent gene expression Potential therapeutics for SARS
Drugs		S-(Dimethylarsenic)Cysteine	Acetaminophen Grn163l Copper
Diseases
GWAS		Height ( 31562340) Hip circumference adjusted for BMI ( 34021172) Hip index ( 34021172) Waist-hip index ( 34021172) Waist-to-hip ratio adjusted for BMI ( 26426971 34021172) Waist-to-hip ratio adjusted for BMI (age >50) ( 26426971) Waist-to-hip ratio adjusted for BMI x sex x age interaction (4df test) ( 26426971)	Alanine aminotransferase levels ( 33547301) Asthma ( 31619474) High light scatter reticulocyte count ( 32888494) High light scatter reticulocyte percentage of red cells ( 27863252) Liver enzyme levels (alanine transaminase) ( 33972514) Mean platelet volume ( 22139419) Platelet count ( 22139419) Reticulocyte count ( 32888494)
Interacting Genes		24 interacting genes: ARCN1 ARF1 CDC42 CFTR COPB1 COPE COPG2 COPZ1 COPZ2 DRD1 FILNC1 H2AX PPBP PTGES3 RAB7A RHOQ RNF10 SACM1L SNCA SUMO2 TAPBP TMED10 WBP2 WEE2-AS1	30 interacting genes: AHR AHSA1 AIP ARNT CASP3 CASP7 CAV3 CD2AP CDC37 COPG1 COPG2 DNAJB1 DNMT3A EIF2AK2 ERBB3 ESR1 FES GZMB HSF1 HSP90AA1 HSPA1A HSPB1 MAPT NR3C1 NR3C2 SIM2 STIP1 SURF1 TERT THRA
Entrez ID		22820	10728
HPRD ID		09887	06138
Ensembl ID		ENSG00000181789	ENSG00000110958
Uniprot IDs		Q9Y678	A0A087WYT3 B3KUY2 Q15185
PDB IDs		1R4X	1EJF 7KRJ 7L7I 7L7J
Enriched GO Terms of Interacting Partners?		COPI Vesicle Coat COPI-coated Vesicle Membrane Retrograde Vesicle-mediated Transport, Golgi To Endoplasmic Reticulum COPI-coated Vesicle Vesicle-mediated Transport Transport Vesicle Golgi Membrane Intra-Golgi Vesicle-mediated Transport Golgi Vesicle Transport Endoplasmic Reticulum Membrane Establishment Of Localization In Cell Intracellular Protein Transport Intracellular Transport Establishment Of Protein Localization Endoplasmic Reticulum To Golgi Vesicle-mediated Transport Protein Transport Intracellular Protein Localization GBD Domain Binding Cellular Localization Golgi Apparatus Membrane Coat Cytoplasmic Vesicle Organelle Localization Regulation Of Dopamine Uptake Involved In Synaptic Transmission Positive Regulation Of Transport Glutamatergic Synapse Golgi Localization Golgi-associated Vesicle Membrane Adult Locomotory Behavior Endoplasmic Reticulum-Golgi Intermediate Compartment Synaptic Transmission, Dopaminergic Endoplasmic Reticulum-Golgi Intermediate Compartment Membrane Long-term Synaptic Depression Positive Regulation Of Exocytosis Behavioral Response To Cocaine Vesicle-mediated Transport In Synapse Bounding Membrane Of Organelle Secretory Granule Membrane Regulation Of Dopamine Metabolic Process Dopamine Transport Regulation Of Neurotransmitter Uptake Establishment Of Organelle Localization Positive Regulation Of Monoatomic Ion Transmembrane Transport D-glucose Transmembrane Transport Positive Regulation Of Secretion By Cell Positive Regulation Of Filopodium Assembly Monoamine Transport Dopamine Metabolic Process Regulation Of Vesicle-mediated Transport GTPase Activity	Hsp90 Protein Binding Nuclear Receptor Activity TBP-class Protein Binding Unfolded Protein Binding Response To Temperature Stimulus Response To Heat Regulation Of Gene Expression Cellular Response To Heat Regulation Of Macromolecule Biosynthetic Process Response To Lipid Protein Folding Chaperone Regulation Of Macromolecule Metabolic Process Aryl Hydrocarbon Receptor Complex Regulation Of Apoptotic Process Protein Folding Chaperone Complex Cytoplasm Positive Regulation Of Microtubule Polymerization Positive Regulation Of Protein Polymerization Response To Unfolded Protein Regulation Of Programmed Cell Death Regulation Of Primary Metabolic Process Intracellular Signal Transduction Regulation Of Metabolic Process Cytosol Response To Stress Regulation Of Protein-containing Complex Assembly Estrogen Response Element Binding Negative Regulation Of Macromolecule Biosynthetic Process Cellular Response To Lipid Protein-folding Chaperone Binding Negative Regulation Of Inclusion Body Assembly Protein Folding Negative Regulation Of Biosynthetic Process Animal Organ Development Regulation Of Cellular Response To Heat Intracellular Receptor Signaling Pathway Nuclear Aryl Hydrocarbon Receptor Complex Neurofibrillary Tangle Assembly Protein-containing Complex Regulation Of Neuron Apoptotic Process Regulation Of Microtubule Polymerization Regulation Of Inclusion Body Assembly Negative Regulation Of Macromolecule Metabolic Process Regulation Of Multicellular Organismal Process Response To Hormone Positive Regulation Of Metabolic Process Response To Hypoxia Sequence-specific DNA Binding Cellular Response To Oxygen-containing Compound DNA-binding Transcription Factor Activity
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