FGF6 and CELSR1

		FGF6	CELSR1
Description		fibroblast growth factor 6	cadherin EGF LAG seven-pass G-type receptor 1
Image		No pdb structure
GO Annotations	Cellular Component	Extracellular Region Extracellular Space Cytoplasm Sarcolemma	Nucleoplasm Plasma Membrane Adherens Junction Membrane
	Molecular Function	Fibroblast Growth Factor Receptor Binding Protein Binding Growth Factor Activity	Transmembrane Signaling Receptor Activity G Protein-coupled Receptor Activity Calcium Ion Binding
	Biological Process	Cartilage Condensation Angiogenesis Positive Regulation Of Cell Population Proliferation Fibroblast Growth Factor Receptor Signaling Pathway Neurogenesis Cell Differentiation Regulation Of Cell Migration Positive Regulation Of MAPK Cascade Myoblast Differentiation Positive Regulation Of Cell Division	Establishment Of Planar Polarity Neuron Migration Neural Tube Closure Cell Adhesion Homophilic Cell Adhesion Via Plasma Membrane Adhesion Molecules Signal Transduction Cell Surface Receptor Signaling Pathway G Protein-coupled Receptor Signaling Pathway Rho Protein Signal Transduction Nervous System Development Axonogenesis Central Nervous System Development Regulation Of Actin Cytoskeleton Organization Establishment Of Planar Polarity Of Embryonic Epithelium Cell-cell Adhesion Mediated By Cadherin Apical Protein Localization Establishment Of Body Hair Planar Orientation Wnt Signaling Pathway, Planar Cell Polarity Pathway Orthogonal Dichotomous Subdivision Of Terminal Units Involved In Lung Branching Morphogenesis Planar Dichotomous Subdivision Of Terminal Units Involved In Lung Branching Morphogenesis Lateral Sprouting Involved In Lung Morphogenesis Protein Localization Involved In Establishment Of Planar Polarity
Pathways		PI3K Cascade PIP3 activates AKT signaling Signaling by activated point mutants of FGFR1 FGFR4 ligand binding and activation FGFR1c ligand binding and activation FGFR2c ligand binding and activation Activated point mutants of FGFR2 Constitutive Signaling by Aberrant PI3K in Cancer Phospholipase C-mediated cascade: FGFR1 Phospholipase C-mediated cascade; FGFR2 Phospholipase C-mediated cascade; FGFR4 Downstream signaling of activated FGFR1 SHC-mediated cascade:FGFR1 PI-3K cascade:FGFR1 FRS-mediated FGFR1 signaling PI-3K cascade:FGFR2 SHC-mediated cascade:FGFR2 FRS-mediated FGFR2 signaling FRS-mediated FGFR4 signaling SHC-mediated cascade:FGFR4 PI-3K cascade:FGFR4 Negative regulation of FGFR1 signaling Negative regulation of FGFR2 signaling Negative regulation of FGFR4 signaling Signaling by FGFR2 in disease Signaling by FGFR1 in disease RAF/MAP kinase cascade PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling
Drugs
Diseases
GWAS		Colorectal cancer ( 23263487) Medication use (antimigraine preparations) ( 31015401) Migraine ( 27182965 27322543) Migraine without aura ( 27322543) Phosphorus levels ( 20558539 29403010) Response to cytadine analogues (cytosine arabinoside) ( 24483146)	Disease progression in age-related macular degeneration (adjusted for baseline) ( 29346644) HDL cholesterol change in response to fenofibrate in statin-treated type 2 diabetes ( 28736931) Heel bone mineral density ( 30598549) Iris color (L* coordinate) ( 30895295) Left–right brain asymmetry ( 33723403) Urate levels in obese individuals ( 25811787)
Interacting Genes		7 interacting genes: CELSR1 FGFR1 FGFR2 FGFR3 FGFR4 KLRC2 NCALD	2 interacting genes: FGF6 PSAP
Entrez ID		2251	9620
HPRD ID		00623	05160
Ensembl ID		ENSG00000111241	ENSG00000075275
Uniprot IDs		A0A7U3JW05 P10767	A0A6I8PRU0 Q9NYQ6
PDB IDs			7SZ8 8D40
Enriched GO Terms of Interacting Partners?		Fibroblast Growth Factor Receptor Activity Fibroblast Growth Factor Binding Positive Regulation Of Phospholipase Activity Positive Regulation Of Lipase Activity Transmembrane Receptor Protein Tyrosine Kinase Activity Receptor Complex Fibroblast Growth Factor Receptor Signaling Pathway Protein Tyrosine Kinase Activity Fibroblast Growth Factor Receptor Signaling Pathway Involved In Orbitofrontal Cortex Development Ventricular Zone Neuroblast Division Orbitofrontal Cortex Development Peptidyl-tyrosine Phosphorylation Forebrain Neuroblast Division Forebrain Ventricular Zone Progenitor Cell Division Positive Regulation Of Catalytic Activity Lung-associated Mesenchyme Development Endochondral Bone Growth Lateral Sprouting From An Epithelium Biomineral Tissue Development Branching Involved In Salivary Gland Morphogenesis Positive Regulation Of Hydrolase Activity Protein Autophosphorylation Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Cell Surface Receptor Signaling Pathway Positive Regulation Of MAPK Cascade Bone Growth Protein Kinase Activity Heparin Binding Regulation Of Catalytic Activity Positive Regulation Of ERK1 And ERK2 Cascade Mesenchymal Cell Proliferation Positive Regulation Of Mesenchymal Cell Proliferation Positive Regulation Of Cardiac Muscle Cell Proliferation Kinase Activity Signal Transduction Gland Morphogenesis Cellular Response To Fibroblast Growth Factor Stimulus Enzyme-linked Receptor Protein Signaling Pathway Regulation Of MAPK Cascade Midbrain Development Regulation Of Mesenchymal Cell Proliferation Bone Morphogenesis Positive Regulation Of Heart Growth Response To Fibroblast Growth Factor Ureteric Bud Development Regulation Of Cardiac Muscle Cell Proliferation Regulation Of ERK1 And ERK2 Cascade Mesonephric Tubule Development Mesonephric Epithelium Development Positive Regulation Of Organ Growth	Ganglioside GM3 Binding Ganglioside GP1c Binding Positive Regulation Of Beta-galactosidase Activity Ganglioside GM1 Transport To Membrane Ganglioside GM2 Binding Ganglioside GT1b Binding Ganglioside GM1 Binding Glycolipid Transport Prostate Gland Growth Epithelial Cell Differentiation Involved In Prostate Gland Development Ceramide Transport Cell Aggregation Cartilage Condensation Fibroblast Growth Factor Receptor Binding Myoblast Differentiation Azurophil Granule Membrane Organ Growth Fibroblast Growth Factor Receptor Signaling Pathway Extracellular Space Carbohydrate Derivative Transport Enzyme Activator Activity Scaffold Protein Binding Positive Regulation Of Cell Division Adenylate Cyclase-inhibiting G Protein-coupled Receptor Signaling Pathway Lysosomal Lumen
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