FGF6 and KLRC2

		FGF6	KLRC2
Description		fibroblast growth factor 6	killer cell lectin like receptor C2
Image		No pdb structure
GO Annotations	Cellular Component	Extracellular Region Extracellular Space Cytoplasm Sarcolemma	Plasma Membrane External Side Of Plasma Membrane Membrane Receptor Complex
	Molecular Function	Fibroblast Growth Factor Receptor Binding Protein Binding Growth Factor Activity	Transmembrane Signaling Receptor Activity Protein Binding MHC Class I Protein Complex Binding Carbohydrate Binding MHC Class Ib Receptor Activity Activating MHC Class Ib Receptor Activity Protein Antigen Binding
	Biological Process	Cartilage Condensation Angiogenesis Positive Regulation Of Cell Population Proliferation Fibroblast Growth Factor Receptor Signaling Pathway Neurogenesis Cell Differentiation Regulation Of Cell Migration Positive Regulation Of MAPK Cascade Myoblast Differentiation Positive Regulation Of Cell Division	Stimulatory C-type Lectin Receptor Signaling Pathway Natural Killer Cell Mediated Immunity Adaptive Immune Response Immune System Process Immune Response-regulating Cell Surface Receptor Signaling Pathway Cellular Defense Response Signal Transduction Regulation Of Natural Killer Cell Activation Regulation Of Natural Killer Cell Mediated Cytotoxicity Positive Regulation Of Natural Killer Cell Degranulation Innate Immune Response Positive Regulation Of Natural Killer Cell Mediated Cytotoxicity
Pathways		PI3K Cascade PIP3 activates AKT signaling Signaling by activated point mutants of FGFR1 FGFR4 ligand binding and activation FGFR1c ligand binding and activation FGFR2c ligand binding and activation Activated point mutants of FGFR2 Constitutive Signaling by Aberrant PI3K in Cancer Phospholipase C-mediated cascade: FGFR1 Phospholipase C-mediated cascade; FGFR2 Phospholipase C-mediated cascade; FGFR4 Downstream signaling of activated FGFR1 SHC-mediated cascade:FGFR1 PI-3K cascade:FGFR1 FRS-mediated FGFR1 signaling PI-3K cascade:FGFR2 SHC-mediated cascade:FGFR2 FRS-mediated FGFR2 signaling FRS-mediated FGFR4 signaling SHC-mediated cascade:FGFR4 PI-3K cascade:FGFR4 Negative regulation of FGFR1 signaling Negative regulation of FGFR2 signaling Negative regulation of FGFR4 signaling Signaling by FGFR2 in disease Signaling by FGFR1 in disease RAF/MAP kinase cascade PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling	DAP12 interactions DAP12 signaling DAP12 signaling
Drugs
Diseases
GWAS		Colorectal cancer ( 23263487) Medication use (antimigraine preparations) ( 31015401) Migraine ( 27182965 27322543) Migraine without aura ( 27322543) Phosphorus levels ( 20558539 29403010) Response to cytadine analogues (cytosine arabinoside) ( 24483146)	Alanine aminotransferase levels ( 33547301) Aspartate aminotransferase levels ( 33547301) Composite immunoglobulin trait (IgA/IgG) ( 28628107) Liver enzyme levels (alanine transaminase) ( 33972514) Lymphocyte count ( 32888494) Monocyte count ( 32888494) Monocyte percentage of white cells ( 32888494) Neutrophil percentage of white cells ( 27863252 32888494) Plateletcrit ( 32888494) Red blood cell count ( 32888494)
Interacting Genes		7 interacting genes: CELSR1 FGFR1 FGFR2 FGFR3 FGFR4 KLRC2 NCALD	5 interacting genes: FBP1 FGF6 HLA-E KLRD1 NIF3L1
Entrez ID		2251	3822
HPRD ID		00623	04202
Ensembl ID		ENSG00000111241	ENSG00000205809
Uniprot IDs		A0A7U3JW05 P10767	P26717
PDB IDs			2L35
Enriched GO Terms of Interacting Partners?		Fibroblast Growth Factor Receptor Activity Fibroblast Growth Factor Binding Positive Regulation Of Phospholipase Activity Positive Regulation Of Lipase Activity Transmembrane Receptor Protein Tyrosine Kinase Activity Receptor Complex Fibroblast Growth Factor Receptor Signaling Pathway Protein Tyrosine Kinase Activity Fibroblast Growth Factor Receptor Signaling Pathway Involved In Orbitofrontal Cortex Development Ventricular Zone Neuroblast Division Orbitofrontal Cortex Development Peptidyl-tyrosine Phosphorylation Forebrain Neuroblast Division Forebrain Ventricular Zone Progenitor Cell Division Positive Regulation Of Catalytic Activity Lung-associated Mesenchyme Development Endochondral Bone Growth Lateral Sprouting From An Epithelium Biomineral Tissue Development Branching Involved In Salivary Gland Morphogenesis Positive Regulation Of Hydrolase Activity Protein Autophosphorylation Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Cell Surface Receptor Signaling Pathway Positive Regulation Of MAPK Cascade Bone Growth Protein Kinase Activity Heparin Binding Regulation Of Catalytic Activity Positive Regulation Of ERK1 And ERK2 Cascade Mesenchymal Cell Proliferation Positive Regulation Of Mesenchymal Cell Proliferation Positive Regulation Of Cardiac Muscle Cell Proliferation Kinase Activity Signal Transduction Gland Morphogenesis Cellular Response To Fibroblast Growth Factor Stimulus Enzyme-linked Receptor Protein Signaling Pathway Regulation Of MAPK Cascade Midbrain Development Regulation Of Mesenchymal Cell Proliferation Bone Morphogenesis Positive Regulation Of Heart Growth Response To Fibroblast Growth Factor Ureteric Bud Development Regulation Of Cardiac Muscle Cell Proliferation Regulation Of ERK1 And ERK2 Cascade Mesonephric Tubule Development Mesonephric Epithelium Development Positive Regulation Of Organ Growth	Positive Regulation Of Natural Killer Cell Mediated Cytotoxicity Negative Regulation Of Natural Killer Cell Mediated Cytotoxicity Positive Regulation Of Natural Killer Cell Mediated Immunity Natural Killer Cell Mediated Immunity Regulation Of Natural Killer Cell Activation Regulation Of T Cell Mediated Cytotoxicity Regulation Of Natural Killer Cell Mediated Cytotoxicity Regulation Of Natural Killer Cell Mediated Immunity Positive Regulation Of Leukocyte Mediated Cytotoxicity Positive Regulation Of Cell Killing Positive Regulation Of Antibody-dependent Cellular Cytotoxicity Negative Regulation Of Innate Immune Response Regulation Of Leukocyte Mediated Cytotoxicity Phosphoric Ester Hydrolase Activity Cellular Response To Raffinose Fructose 1,6-bisphosphate 1-phosphatase Activity Regulation Of T Cell Mediated Immunity Positive Regulation Of Lymphocyte Mediated Immunity Lymphocyte Mediated Immunity MHC Class Ib Protein Complex Positive Regulation Of TRAIL Production HLA-E Specific Inhibitory MHC Class Ib Receptor Activity MHC Class Ib Protein Binding, Via Antigen Binding Groove Leukocyte Mediated Immunity Cellular Hypotonic Salinity Response Positive Regulation Of CD8-positive, Alpha-beta T Cell Proliferation Regulation Of TRAIL Production Natural Killer Cell Tolerance Induction Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class Ib Positive Regulation Of Type IIa Hypersensitivity RNA Polymerase II-specific DNA-binding Transcription Factor Binding Regulation Of Lymphocyte Mediated Immunity Cellular Hyperosmotic Salinity Response Regulation Of Adaptive Immune Response Based On Somatic Recombination Of Immune Receptors Built From Immunoglobulin Superfamily Domains Negative Regulation Of Immune Response Regulation Of Adaptive Immune Response Hyperosmotic Salinity Response Cellular Response To Magnesium Ion Protection From Natural Killer Cell Mediated Cytotoxicity Monosaccharide Binding Positive Regulation Of Hypersensitivity MHC Class I Protein Complex Binding Fructose 1,6-bisphosphate Metabolic Process Positive Regulation Of Acute Inflammatory Response To Antigenic Stimulus Beta-2-microglobulin Binding Regulation Of CD8-positive, Alpha-beta T Cell Proliferation Positive Regulation Of CD8-positive, Alpha-beta T Cell Activation Natural Killer Cell Lectin-like Receptor Binding Positive Regulation Of Immune Effector Process MHC Class I Protein Complex
Tagcloud ?
Tagcloud (Difference) ?
Tagcloud (Intersection) ?