FCER2 and ATF7

Number of citations of the paper that reports this interaction (PubMedID 25416956)
56

Data Source:
BioGRID (two hybrid)

		FCER2	ATF7
Description		Fc epsilon receptor II	activating transcription factor 7
Image			No pdb structure
GO Annotations	Cellular Component	Extracellular Region Plasma Membrane External Side Of Plasma Membrane Membrane Extracellular Exosome	Chromosome, Telomeric Region Chromatin Nucleus Nucleoplasm Chromosome Cytoplasm RNA Polymerase II Transcription Regulator Complex
	Molecular Function	Protease Binding Integrin Binding Protein Binding Low-affinity IgE Receptor Activity IgE Binding Carbohydrate Binding Pattern Recognition Receptor Activity Metal Ion Binding	Transcription Cis-regulatory Region Binding RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific Transcription Coactivator Binding DNA-binding Transcription Repressor Activity, RNA Polymerase II-specific DNA Binding DNA-binding Transcription Factor Activity Protein Binding Zinc Ion Binding Enzyme Binding CAMP Response Element Binding Metal Ion Binding Mitogen-activated Protein Kinase Binding Sequence-specific Double-stranded DNA Binding
	Biological Process	B Cell Antigen Processing And Presentation Positive Regulation Of Humoral Immune Response Mediated By Circulating Immunoglobulin Immune Response Positive Regulation Of Gene Expression Fc-epsilon Receptor Signaling Pathway Fc-gamma Receptor Signaling Pathway Involved In Phagocytosis Macrophage Activation Defense Response To Bacterium Fc Receptor-mediated Immune Complex Endocytosis	Negative Regulation Of Transcription By RNA Polymerase II Regulation Of DNA-templated Transcription Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Transcription By RNA Polymerase II
Pathways		NOTCH2 intracellular domain regulates transcription Interleukin-10 signaling Interleukin-4 and Interleukin-13 signaling
Drugs		Lumiliximab	Pseudoephedrine
Diseases
GWAS		Blood protein levels ( 30072576) Post bronchodilator FEV1 ( 26634245)	Basophil count ( 32888494) Electroencephalogram traits ( 25387704) Heel bone mineral density ( 30598549) Height ( 20189936 21998595 25429064 31562340) Lymphocyte percentage of white cells ( 32888494) Monocyte count ( 32888494) Monocyte percentage of white cells ( 32888494) Neutrophil count ( 32888494) Neutrophil percentage of white cells ( 32888494) Waist-to-hip ratio adjusted for BMI ( 26426971) Waist-to-hip ratio adjusted for BMI (age <50) ( 26426971) Waist-to-hip ratio adjusted for BMI (age >50) ( 26426971) Waist-to-hip ratio adjusted for BMI x sex x age interaction (4df test) ( 26426971)
Interacting Genes		6 interacting genes: ATF7 CR2 FYN ITGAX ITGB2 XRCC6	18 interacting genes: ATF2 FAM9B FCER2 FOS KASH5 MAPK9 MBD3 MITD1 OCIAD1 PTP4A1 PTP4A2 TAF12 TAF4 TAOK3 TMEM239 UBC URI1 YY1
Entrez ID		2208	11016
HPRD ID		01049	06968
Ensembl ID		ENSG00000104921	ENSG00000170653
Uniprot IDs		K3W4U1 P06734	P17544
PDB IDs		1T8C 1T8D 2H2R 2H2T 4EZM 4G96 4G9A 4GI0 4GJ0 4GJX 4GK1 4GKO 4J6J 4J6K 4J6L 4J6M 4J6N 4J6P 4J6Q 4KI1 5LGK 6Y0L 6Y0M
Enriched GO Terms of Interacting Partners?		Integrin AlphaX-beta2 Complex Positive Regulation Of Immune Response Positive Regulation Of Protein Targeting To Membrane Integrin Complex Regulation Of Protein Targeting To Membrane Heterotypic Cell-cell Adhesion Regulation Of Immune Response Positive Regulation Of Immune System Process Regulation Of Vasculature Development Protein-containing Complex Binding Regulation Of Angiogenesis Ficolin-1-rich Granule Membrane Tertiary Granule Membrane Scaffold Protein Binding Activation Of Immune Response Cellular Response To Glycine Response To Singlet Oxygen Leukocyte Activation Defense Response Lymphocyte Proliferation Response To Glycine Regulation Of Multicellular Organismal Development Cell-matrix Adhesion Positive Regulation Of Endothelial Tube Morphogenesis Integrin-mediated Signaling Pathway Integrin AlphaM-beta2 Complex Integrin AlphaL-beta2 Complex Mononuclear Cell Proliferation Leukocyte Proliferation Cell Activation Response To Stress Regulation Of Immune System Process Regulation Of Protein Modification Process Regulation Of Reactive Oxygen Species Metabolic Process Regulation Of Cell Shape Negative Regulation Of Hydrogen Peroxide Biosynthetic Process DNA End Binding Ku70:Ku80 Complex ICAM-3 Receptor Activity Positive Regulation Of Neutrophil Degranulation Integrin Binding Positive Regulation Of Multicellular Organismal Process Cell-substrate Adhesion CD8 Receptor Binding Type 5 Metabotropic Glutamate Receptor Binding Negative Regulation Of Dopamine Metabolic Process Immune System Process Negative Regulation Of Dendritic Spine Maintenance Growth Factor Receptor Binding Cellular Hyperosmotic Salinity Response	MRNA Transcription By RNA Polymerase II MRNA Transcription DNA-templated Transcription Positive Regulation Of Macromolecule Metabolic Process Abducens Nucleus Development Mitotic DNA Integrity Checkpoint Signaling Cellular Response To Anisomycin Growth Plate Cartilage Chondrocyte Differentiation Intrinsic Apoptotic Signaling Pathway In Response To Hypoxia Chromatin Binding Nucleoplasm Positive Regulation Of Cardiac Muscle Myoblast Proliferation Facial Nucleus Development Histone H2B Acetyltransferase Activity Promoter-specific Chromatin Binding DNA Damage Response Hypoglossal Nucleus Development Positive Regulation Of Nucleobase-containing Compound Metabolic Process JNK Cascade Nucleus RNA Polymerase II-specific DNA-binding Transcription Factor Binding Cellular Response To Stress H4 Histone Acetyltransferase Complex Positive Regulation Of Transforming Growth Factor Beta2 Production Transcription By RNA Polymerase II Cellular Response To Chemical Stress Growth Plate Cartilage Chondrocyte Proliferation Positive Regulation Of RNA Metabolic Process Mitotic DNA Damage Checkpoint Signaling Cellular Response To Oxidative Stress Positive Regulation Of Macromolecule Biosynthetic Process Nucleic Acid Metabolic Process MAPK Cascade B Cell Antigen Processing And Presentation Fc Receptor Signaling Pathway Low-affinity IgE Receptor Activity Fc Receptor-mediated Immune Complex Endocytosis Fc-epsilon Receptor Signaling Pathway Response To Prolactin Conditioned Taste Aversion Regulation Of MiRNA Transcription Medium-term Memory Cellular Response To Prolactin JUN Kinase Activity Protein Localization To Tricellular Tight Junction Regulation Of Cellular Response To Stress Transcription Factor TFTC Complex Transcription Factor TFIID Complex Transcription Preinitiation Complex Assembly Positive Regulation Of DNA-templated Transcription Initiation
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