FCER2

Description		Fc epsilon receptor II
Image
GO Annotations	Cellular Component	Extracellular Region Plasma Membrane External Side Of Plasma Membrane Membrane Extracellular Exosome
	Molecular Function	Protease Binding Integrin Binding Protein Binding Low-affinity IgE Receptor Activity IgE Binding Carbohydrate Binding Pattern Recognition Receptor Activity Metal Ion Binding
	Biological Process	B Cell Antigen Processing And Presentation Positive Regulation Of Humoral Immune Response Mediated By Circulating Immunoglobulin Immune Response Positive Regulation Of Gene Expression Fc-epsilon Receptor Signaling Pathway Fc-gamma Receptor Signaling Pathway Involved In Phagocytosis Macrophage Activation Defense Response To Bacterium Fc Receptor-mediated Immune Complex Endocytosis
Pathways		NOTCH2 intracellular domain regulates transcription Interleukin-10 signaling Interleukin-4 and Interleukin-13 signaling
Drugs		Lumiliximab
Diseases
GWAS		Blood protein levels ( 30072576) Post bronchodilator FEV1 ( 26634245)
Novel Interacting Genes		6 novel interacting genes: ATF7 CR2 FYN ITGAX ITGB2 XRCC6
Interacting Genes		6 interacting genes: ATF7 CR2 FYN ITGAX ITGB2 XRCC6
Entrez ID		2208
HPRD ID		01049
Ensembl ID		ENSG00000104921
Uniprot IDs		K3W4U1 P06734
PDB IDs		1T8C 1T8D 2H2R 2H2T 4EZM 4G96 4G9A 4GI0 4GJ0 4GJX 4GK1 4GKO 4J6J 4J6K 4J6L 4J6M 4J6N 4J6P 4J6Q 4KI1 5LGK 6Y0L 6Y0M
Enriched GO Terms of Interacting Partners?		Integrin AlphaX-beta2 Complex Positive Regulation Of Immune Response Positive Regulation Of Protein Targeting To Membrane Integrin Complex Regulation Of Protein Targeting To Membrane Heterotypic Cell-cell Adhesion Regulation Of Immune Response Positive Regulation Of Immune System Process Regulation Of Vasculature Development Protein-containing Complex Binding Regulation Of Angiogenesis Ficolin-1-rich Granule Membrane Tertiary Granule Membrane Scaffold Protein Binding Activation Of Immune Response Cellular Response To Glycine Response To Singlet Oxygen Leukocyte Activation Defense Response Lymphocyte Proliferation Response To Glycine Regulation Of Multicellular Organismal Development Cell-matrix Adhesion Positive Regulation Of Endothelial Tube Morphogenesis Integrin-mediated Signaling Pathway Integrin AlphaM-beta2 Complex Integrin AlphaL-beta2 Complex Mononuclear Cell Proliferation Leukocyte Proliferation Cell Activation Response To Stress Regulation Of Immune System Process Regulation Of Protein Modification Process Regulation Of Reactive Oxygen Species Metabolic Process Regulation Of Cell Shape Negative Regulation Of Hydrogen Peroxide Biosynthetic Process DNA End Binding Ku70:Ku80 Complex ICAM-3 Receptor Activity Positive Regulation Of Neutrophil Degranulation Integrin Binding Positive Regulation Of Multicellular Organismal Process Cell-substrate Adhesion CD8 Receptor Binding Type 5 Metabotropic Glutamate Receptor Binding Negative Regulation Of Dopamine Metabolic Process Immune System Process Negative Regulation Of Dendritic Spine Maintenance Growth Factor Receptor Binding Cellular Hyperosmotic Salinity Response
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