ERG and FLI1

Number of citations of the paper that reports this interaction (PubMedID 9681824)
0

Data Source:
HPRD (in vitro)

		ERG	FLI1
Description		ETS transcription factor ERG	Fli-1 proto-oncogene, ETS transcription factor
Image
GO Annotations	Cellular Component	Chromatin Nucleus Nucleoplasm Cytoplasm Cytosol Ribonucleoprotein Complex	Chromatin Nucleus Nucleoplasm Cytosol Nuclear Body
	Molecular Function	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Activator Activity, RNA Polymerase II-specific DNA Binding Chromatin Binding DNA-binding Transcription Factor Activity Protein Binding Sequence-specific DNA Binding Sequence-specific Double-stranded DNA Binding	Transcription Cis-regulatory Region Binding RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Activator Activity, RNA Polymerase II-specific DNA Binding Chromatin Binding DNA-binding Transcription Factor Activity Protein Binding Sequence-specific DNA Binding Sequence-specific Double-stranded DNA Binding
	Biological Process	Regulation Of DNA-templated Transcription Regulation Of Transcription By RNA Polymerase II Protein Phosphorylation Signal Transduction Cell Differentiation Positive Regulation Of Transcription By RNA Polymerase II	Regulation Of DNA-templated Transcription Regulation Of Transcription By RNA Polymerase II Hemostasis Blood Circulation Animal Organ Morphogenesis Cell Differentiation Megakaryocyte Development Positive Regulation Of DNA-templated Transcription Positive Regulation Of Transcription By RNA Polymerase II
Pathways			Transcriptional regulation of granulopoiesis
Drugs
Diseases		Prostate cancer Ewing's sarcoma	Ewing's sarcoma
GWAS		Abdominal aortic aneurysm ( 27899403) Amyotrophic lateral sclerosis (sporadic) ( 24529757) Appendicular lean mass ( 33097823) B-cell acute lymphoblastic leukaemia ( 31767839) B-cell acute lymphoblastic leukaemia (high-hyperdiploidy) ( 31767839) Diastolic blood pressure ( 27841878 30578418) Eosinophil count ( 32888494) Eosinophil percentage of white cells ( 32888494) General cognitive ability ( 25383866) Granulocyte percentage of myeloid white cells ( 27863252) Gut microbiota relative abundance (Blautia) ( 33208821) Heel bone mineral density ( 30598549 28869591) Hematocrit ( 32888494) Hemoglobin ( 32888494) Iron status biomarkers (iron levels) ( 28334935) Keratinocyte cancer (MTAG) ( 31174203) Lymphocyte percentage of white cells ( 32888494) Mean corpuscular hemoglobin ( 27863252 32888494) Mean corpuscular volume ( 27863252 32888494) Mean reticulocyte volume ( 32888494) Mean spheric corpuscular volume ( 32888494) Metabolite levels (HVA) ( 23319000) Monocyte count ( 32888494) Monocyte percentage of white cells ( 32888494 27863252) Multiple sclerosis ( 27386562 31604244) Neonatal lupus ( 20662065) Neutrophil count ( 32888494) Non-response to antidepressants and depression ( 27622933) Platelet count ( 27863252 32888494) Plateletcrit ( 27863252 32888494) Pulse pressure ( 27841878 30578418) Red blood cell count ( 32888494) Refractive error ( 32231278) Response to cognitive-behavioural therapy in anxiety disorder ( 26989097) Sum eosinophil basophil counts ( 27863252) White blood cell count ( 32888494) White blood cell count (basophil) ( 29403010) White blood cell types ( 21738478)	Albumin-globulin ratio ( 29403010) Amyotrophic lateral sclerosis (sporadic) ( 24529757) Corneal astigmatism ( 30306274) Coronary artery calcified atherosclerotic plaque (130 HU threshold) in type 2 diabetes ( 29221444) Digit length ratio ( 29659830) Digit length ratio (left hand) ( 29659830) Digit length ratio (right hand) ( 29659830) Eosinophil count ( 32888494) Eosinophil percentage of white cells ( 32888494) Heel bone mineral density ( 30598549) Height ( 31562340 20881960) Hip circumference adjusted for BMI ( 34021172) Left ventricular obstructive tract defect (inherited effect) ( 28468790) Mean corpuscular volume ( 32888494) Mean spheric corpuscular volume ( 32888494) Monocyte count ( 32888494) Monocyte percentage of white cells ( 32888494) Myopia (pathological) ( 23049088) Non-albumin protein levels ( 29403010) Platelet count ( 27863252 32888494) Plateletcrit ( 27863252 32888494) Refractive error ( 32231278) Rheumatoid arthritis ( 22446963) Rheumatoid arthritis (ACPA-positive) ( 24532676) Systemic lupus erythematosus ( 27399966 26502338) Type 1 diabetes ( 34012112 34127860) Vitiligo ( 27723757)
Interacting Genes		106 interacting genes: ACTB ADAR APP ARK2N ATP5PD CDC5L CLTC COL6A2 CRYAA CSTB DDX21 DDX23 DKC1 DNAJA1 DNAJA2 DNAJA4 EEF1A2 ELAVL1 ETS2 ETV1 EXOSC9 FAM218A FBL FLI1 HERC2 HIPK1 HNRNPA1 HNRNPA2B1 HNRNPAB HNRNPC HNRNPD HNRNPDL HNRNPF HNRNPH1 HNRNPH3 HNRNPU HNRNPUL1 HNRNPUL2 HSPD1 HUWE1 ILF2 ILF3 ITGB2 JUN LANCL1 LARS1 MATR3 MNAT1 MSH3 MYO5A NCL NEUROD2 NFIA NFIB NFIC NOLC1 NONO NPM1 NUMA1 PARP1 PCBP1 PDE9A PIAS1 PIAS3 POLR2A PRKDC PRMT2 PRPF40A PRPF8 PTPRD PUF60 PVT1 RCC2 RING1 RNF111 RNF2 RPLP0 SETDB1 SF3B1 SF3B2 SF3B3 SFPQ SLX4 SMARCE1 SNRNP200 SOX10 SOX6 SPI1 SPOP STUB1 SYN1 TARBP1 TOP1 TOP2B TRIM25 TRIM33 TRIP12 UBR4 UBR5 UHRF1 USP9X WDR13 XRN2 ZBED5 ZBTB44 ZMYM2	18 interacting genes: BRCA1 CTBP2 ELK1 ERG ETV6 EWSR1 GATA1 KLF1 PIAS1 PIAS2 PRKCD SIAH1 SMAD3 SMAD9 SOX30 SRF TDP2 UBE2I
Entrez ID		2078	2313
HPRD ID		01298	01901
Ensembl ID		ENSG00000157554	ENSG00000151702
Uniprot IDs		A0A0C4DG41 B4DN83 B4DVX5 B5MDW0 P11308	Q01543
PDB IDs		1SXE 4IRG 4IRH 4IRI 5YBC 5YBD 6VGE 6VGG	1FLI 1X66 2YTU 5E8G 5E8I 5JVT 6VG2 6VG8 6VGD 9CP6 9MWY 9MX8 9MX9 9MXA
Enriched GO Terms of Interacting Partners?		RNA Binding Nucleic Acid Metabolic Process Nucleoplasm Nucleus Nucleobase-containing Compound Metabolic Process RNA Metabolic Process MRNA Splicing, Via Spliceosome RNA Splicing, Via Transesterification Reactions Regulation Of Macromolecule Metabolic Process MRNA Metabolic Process RNA Processing Ribonucleoprotein Complex Macromolecule Metabolic Process Regulation Of Metabolic Process MRNA Processing Regulation Of Primary Metabolic Process RNA Splicing Catalytic Step 2 Spliceosome Spliceosomal Complex Regulation Of Macromolecule Biosynthetic Process Nucleic Acid Binding Regulation Of Gene Expression DNA Metabolic Process DNA Binding Negative Regulation Of Metabolic Process Chromatin Negative Regulation Of Macromolecule Metabolic Process Chromatin Remodeling Positive Regulation Of Nucleobase-containing Compound Metabolic Process Negative Regulation Of Nucleobase-containing Compound Metabolic Process Positive Regulation Of Metabolic Process Regulation Of Nucleobase-containing Compound Metabolic Process Positive Regulation Of Macromolecule Metabolic Process Regulation Of RNA Metabolic Process Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Biosynthetic Process Positive Regulation Of RNA Biosynthetic Process Negative Regulation Of RNA Metabolic Process Positive Regulation Of RNA Metabolic Process Positive Regulation Of DNA-templated Transcription Chromatin Binding Chromatin Organization Regulation Of Telomere Maintenance Via Telomere Lengthening Regulation Of RNA Biosynthetic Process DNA Repair Negative Regulation Of Biosynthetic Process Negative Regulation Of Macromolecule Biosynthetic Process Regulation Of DNA-templated Transcription Alternative MRNA Splicing, Via Spliceosome Nuclear Matrix	Regulation Of RNA Metabolic Process Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Chromatin Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Gene Expression Negative Regulation Of DNA-templated Transcription Regulation Of Macromolecule Biosynthetic Process Regulation Of Primary Metabolic Process Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription DNA Binding Negative Regulation Of RNA Biosynthetic Process DNA-binding Transcription Factor Activity Nucleus Positive Regulation Of RNA Metabolic Process Negative Regulation Of RNA Metabolic Process Regulation Of Macromolecule Metabolic Process Negative Regulation Of Nucleobase-containing Compound Metabolic Process Nucleoplasm Positive Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Biosynthetic Process DNA-binding Transcription Activator Activity, RNA Polymerase II-specific Transcription Cis-regulatory Region Binding Regulation Of Metabolic Process RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding Cellular Developmental Process DNA-binding Transcription Factor Activity, RNA Polymerase II-specific Positive Regulation Of Macromolecule Metabolic Process Positive Regulation Of Macromolecule Biosynthetic Process SUMO Transferase Activity RNA Polymerase II-specific DNA-binding Transcription Factor Binding Negative Regulation Of Macromolecule Biosynthetic Process SMAD Protein Signal Transduction Positive Regulation Of Metabolic Process Negative Regulation Of Biosynthetic Process Cell Differentiation PML Body Sequence-specific DNA Binding Negative Regulation Of Macromolecule Metabolic Process Transcription Coregulator Binding Cellular Response To Oxygen-containing Compound Negative Regulation Of Metabolic Process Protein Sumoylation SMAD Protein Complex Response To Hormone Heteromeric SMAD Protein Complex Developmental Process
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