STX2 and PCGF2

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		STX2	PCGF2
Description		syntaxin 2	polycomb group ring finger 2
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Extracellular Space Plasma Membrane Endomembrane System Membrane Basolateral Plasma Membrane Lamellipodium SNARE Complex Protein-containing Complex Intracellular Membrane-bounded Organelle Presynaptic Active Zone Membrane	Chromatin Sex Chromatin Nucleus Nucleoplasm Nuclear Body PcG Protein Complex PRC1 Complex
	Molecular Function	SNARE Binding Structural Molecule Activity SNAP Receptor Activity Protein Binding Identical Protein Binding Calcium-dependent Protein Binding	DNA Binding Chromatin Binding Protein Binding Zinc Ion Binding Metal Ion Binding Promoter-specific Chromatin Binding
	Biological Process	Intracellular Protein Transport Exocytosis Signal Transduction Acrosome Reaction Ectoderm Development Animal Organ Morphogenesis Vesicle-mediated Transport Synaptic Vesicle Fusion To Presynaptic Active Zone Membrane Cellular Response To Oxidative Stress Vesicle Docking Cornified Envelope Assembly	Negative Regulation Of Transcription By RNA Polymerase II In Utero Embryonic Development Chromatin Organization Chromatin Remodeling Anterior/posterior Pattern Specification Embryonic Skeletal System Morphogenesis Embryonic Skeletal System Development Cellular Response To Hydrogen Peroxide Apoptotic Signaling Pathway Negative Regulation Of Apoptotic Signaling Pathway
Pathways			SUMOylation of DNA damage response and repair proteins SUMOylation of transcription cofactors SUMOylation of chromatin organization proteins SUMOylation of RNA binding proteins SUMOylation of DNA methylation proteins Activation of anterior HOX genes in hindbrain development during early embryogenesis Transcriptional Regulation by E2F6
Drugs
Diseases
GWAS		Initial pursuit acceleration in psychotic disorders ( 29064472) Metabolite levels ( 23823483) Plasma plasminogen activator levels ( 24578379) vWF levels ( 30586737)
Interacting Genes		65 interacting genes: AARD ABI3 ANKRD46 APOL2 BET1 BLOC1S2 CD53 CDC23 CERT1 CPLX2 CTSA CYBC1 EBAG9 ENTPD3 FGA GET1 GIMAP5 MIP MRPL11 MTG1 NAPB NINJ2 PCGF2 PLN PLPP4 RMDN3 RNF4 RTP2 SEC22A SEC22B SERP1 SLC18A1 SNAP25 SNAP29 SNCA STRIT1 STX12 STX16 STX1A STX1B STX3 STX4 STX5 STX6 STX7 STX8 STXBP1 STXBP2 STXBP5L SYT1 SYT4 SYT7 TMEM120A TMEM120B TSPAN8 UBE2I UNC13B VAMP2 VAMP3 VAMP5 VAPB VTI1B ZCCHC12 ZFPL1 ZNF785	26 interacting genes: ABHD6 AKT1 CBX6 CCND2 CD247 CDK2 CTNNAL1 GJB5 HOXC9 HSF2 LMNA OGT PELI2 RBCK1 RNF2 SPDEF STX2 SUMO3 TRAF2 UBE2D3 UBE2E2 UBE2Q2 UBE2T UBE2U USP11 USP7
Entrez ID		2054	7703
HPRD ID		11816	10621
Ensembl ID		ENSG00000111450	ENSG00000277258
Uniprot IDs		A0A994J5V9 A0A994J840 P32856	P35227
PDB IDs
Enriched GO Terms of Interacting Partners?		SNAP Receptor Activity SNARE Complex Organelle Localization By Membrane Tethering SNARE Binding Membrane Docking Vesicle Docking Vesicle Fusion Organelle Membrane Fusion Membrane Fusion Organelle Fusion Vesicle Organization Membrane Organization Organelle Localization Syntaxin Binding Vesicle-mediated Transport Establishment Of Localization In Cell Synaptic Vesicle Exocytosis Exocytosis Calcium-ion Regulated Exocytosis Cellular Localization Syntaxin-1 Binding Secretion By Cell Regulated Exocytosis Vesicle Docking Involved In Exocytosis Vesicle-mediated Transport In Synapse Neurotransmitter Transport Calcium Ion-regulated Exocytosis Of Neurotransmitter Establishment Of Protein Localization Intracellular Transport Protein Transport Secretion Endomembrane System Signal Release SNARE Complex Assembly Synaptic Vesicle Membrane Membrane Regulation Of Exocytosis Regulation Of Secretion By Cell Regulation Of Synaptic Vesicle Priming Regulation Of Secretion Positive Regulation Of Exocytosis Intracellular Protein Transport Vesicle Intracellular Protein Localization Synaptic Vesicle Neuronal Dense Core Vesicle Exocytosis Regulation Of Vesicle Fusion Positive Regulation Of Synaptic Transmission Synaptic Vesicle Priming Positive Regulation Of Calcium Ion-dependent Exocytosis	Post-translational Protein Modification Protein Modification By Small Protein Conjugation Protein Polyubiquitination Protein Ubiquitination Protein Modification Process Ubiquitin Conjugating Enzyme Activity Ubiquitin-protein Transferase Activity Protein K11-linked Ubiquitination Transferase Activity TORC1 Signaling Protein Metabolic Process Protein K6-linked Ubiquitination TOR Signaling Protein K48-linked Ubiquitination Regulation Of Anaphase-promoting Complex-dependent Catabolic Process Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of G1/S Transition Of Mitotic Cell Cycle Cellular Response To Stress Protein Monoubiquitination Macromolecule Metabolic Process Regulation Of G1/S Transition Of Mitotic Cell Cycle Regulation Of Extrinsic Apoptotic Signaling Pathway Positive Regulation Of Cell Cycle G1/S Phase Transition Regulation Of Ubiquitin-dependent Protein Catabolic Process Nucleoplasm Protein K29-linked Ubiquitination Regulation Of Cell Cycle G1/S Phase Transition Regulation Of DNA-binding Transcription Factor Activity Protein Autoubiquitination Ubiquitin Protein Ligase Activity Protein K63-linked Ubiquitination Regulation Of Proteasomal Protein Catabolic Process Cellular Response To Nitric Oxide Cellular Response To Reactive Nitrogen Species Negative Regulation Of Release Of Cytochrome C From Mitochondria Negative Regulation Of Metabolic Process Regulation Of Protein Localization PRC1 Complex Positive Regulation Of Protein Localization To Cell Surface Ubiquitin-like Protein Transferase Activity Positive Regulation Of Mitotic Cell Cycle Phase Transition Regulation Of TORC1 Signaling Regulation Of Glucose Metabolic Process Response To Nitric Oxide Positive Regulation Of Lipid Biosynthetic Process Negative Regulation Of Macromolecule Metabolic Process Positive Regulation Of Cell Cycle Phase Transition PcG Protein Complex Negative Regulation Of RNA Metabolic Process Negative Regulation Of Macromolecule Biosynthetic Process
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