PCGF2 and UBE2Q2

Number of citations of the paper that reports this interaction (PubMedID 19690564)
61

Data Source:
BioGRID (two hybrid)

		PCGF2	UBE2Q2
Description		polycomb group ring finger 2	ubiquitin conjugating enzyme E2 Q2
Image		No pdb structure
GO Annotations	Cellular Component	Chromatin Sex Chromatin Nucleus Nucleoplasm Nuclear Body PcG Protein Complex PRC1 Complex	Nucleus Cytoplasm Cytosol
	Molecular Function	DNA Binding Chromatin Binding Protein Binding Zinc Ion Binding Metal Ion Binding Promoter-specific Chromatin Binding	Nucleotide Binding Ubiquitin-protein Transferase Activity Protein Binding ATP Binding Transferase Activity Ubiquitin Conjugating Enzyme Activity
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II In Utero Embryonic Development Chromatin Organization Chromatin Remodeling Anterior/posterior Pattern Specification Embryonic Skeletal System Morphogenesis Embryonic Skeletal System Development Cellular Response To Hydrogen Peroxide Apoptotic Signaling Pathway Negative Regulation Of Apoptotic Signaling Pathway	Protein Ubiquitination Protein K48-linked Ubiquitination
Pathways		SUMOylation of DNA damage response and repair proteins SUMOylation of transcription cofactors SUMOylation of chromatin organization proteins SUMOylation of RNA binding proteins SUMOylation of DNA methylation proteins Activation of anterior HOX genes in hindbrain development during early embryogenesis Transcriptional Regulation by E2F6	Synthesis of active ubiquitin: roles of E1 and E2 enzymes Antigen processing: Ubiquitination & Proteasome degradation
Drugs
Diseases
GWAS			Chronic kidney disease ( 20383146) Estimated glomerular filtration rate ( 30604766 31015462 31451708) Estimated glomerular filtration rate in diabetes ( 31451708) Glomerular filtration rate ( 29403010) Glomerular filtration rate (creatinine) ( 26831199 28452372) Glomerular filtration rate in non diabetics (creatinine) ( 26831199) Gout ( 33832965) Hemoglobin levels ( 32327693) Red blood cell count ( 32888494) Triglyceride levels in HIV infection ( 33109212) Urate levels ( 23263486 31985003) Urate levels in obese individuals ( 25811787)
Interacting Genes		26 interacting genes: ABHD6 AKT1 CBX6 CCND2 CD247 CDK2 CTNNAL1 GJB5 HOXC9 HSF2 LMNA OGT PELI2 RBCK1 RNF2 SPDEF STX2 SUMO3 TRAF2 UBE2D3 UBE2E2 UBE2Q2 UBE2T UBE2U USP11 USP7	11 interacting genes: BIRC2 BIRC3 HECTD3 ITCH MDM2 PCGF2 RC3H2 RNF111 RNF31 UBA1 UBC
Entrez ID		7703	92912
HPRD ID		10621	14294
Ensembl ID		ENSG00000277258	ENSG00000140367
Uniprot IDs		P35227	Q8WVN8
PDB IDs			1ZUO
Enriched GO Terms of Interacting Partners?		Post-translational Protein Modification Protein Modification By Small Protein Conjugation Protein Polyubiquitination Protein Ubiquitination Protein Modification Process Ubiquitin Conjugating Enzyme Activity Ubiquitin-protein Transferase Activity Protein K11-linked Ubiquitination Transferase Activity TORC1 Signaling Protein Metabolic Process Protein K6-linked Ubiquitination TOR Signaling Protein K48-linked Ubiquitination Regulation Of Anaphase-promoting Complex-dependent Catabolic Process Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of G1/S Transition Of Mitotic Cell Cycle Cellular Response To Stress Protein Monoubiquitination Macromolecule Metabolic Process Regulation Of G1/S Transition Of Mitotic Cell Cycle Regulation Of Extrinsic Apoptotic Signaling Pathway Positive Regulation Of Cell Cycle G1/S Phase Transition Regulation Of Ubiquitin-dependent Protein Catabolic Process Nucleoplasm Protein K29-linked Ubiquitination Regulation Of Cell Cycle G1/S Phase Transition Regulation Of DNA-binding Transcription Factor Activity Protein Autoubiquitination Ubiquitin Protein Ligase Activity Protein K63-linked Ubiquitination Regulation Of Proteasomal Protein Catabolic Process Cellular Response To Nitric Oxide Cellular Response To Reactive Nitrogen Species Negative Regulation Of Release Of Cytochrome C From Mitochondria Negative Regulation Of Metabolic Process Regulation Of Protein Localization PRC1 Complex Positive Regulation Of Protein Localization To Cell Surface Ubiquitin-like Protein Transferase Activity Positive Regulation Of Mitotic Cell Cycle Phase Transition Regulation Of TORC1 Signaling Regulation Of Glucose Metabolic Process Response To Nitric Oxide Positive Regulation Of Lipid Biosynthetic Process Negative Regulation Of Macromolecule Metabolic Process Positive Regulation Of Cell Cycle Phase Transition PcG Protein Complex Negative Regulation Of RNA Metabolic Process Negative Regulation Of Macromolecule Biosynthetic Process	Ubiquitin Protein Ligase Activity Protein Ubiquitination Protein Modification By Small Protein Conjugation Post-translational Protein Modification Modification-dependent Protein Catabolic Process Proteolysis Involved In Protein Catabolic Process Regulation Of Necroptotic Process Ubiquitin-protein Transferase Activity Regulation Of Programmed Necrotic Cell Death Protein Polyubiquitination Ubiquitin-dependent Protein Catabolic Process Macromolecule Catabolic Process Protein Modification Process Proteolysis Negative Regulation Of Necroptotic Process Negative Regulation Of Programmed Necrotic Cell Death Transferase Activity Catabolic Process Protein Metabolic Process Canonical NF-kappaB Signal Transduction Negative Regulation Of Programmed Cell Death Regulation Of Post-translational Protein Modification CD40 Receptor Complex Regulation Of Cytoplasmic Pattern Recognition Receptor Signaling Pathway Ubiquitin Binding Regulation Of Canonical NF-kappaB Signal Transduction Regulation Of Nucleotide-binding Domain, Leucine Rich Repeat Containing Receptor Signaling Pathway Positive Regulation Of Protein Ubiquitination Cysteine-type Endopeptidase Inhibitor Activity Involved In Apoptotic Process Zinc Ion Binding Ligase Activity Protein-containing Complex Positive Regulation Of Post-translational Protein Modification Regulation Of RIG-I Signaling Pathway Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Protein Metabolic Process Regulation Of Signal Transduction Negative Regulation Of Apoptotic Process Regulation Of Programmed Cell Death Proteasomal Protein Catabolic Process Regulation Of Immune Response Non-canonical NF-kappaB Signal Transduction Regulation Of Protein Ubiquitination Negative Regulation Of CD4-positive, Alpha-beta T Cell Activation Regulation Of Cell Communication Regulation Of Signaling Regulation Of Toll-like Receptor Signaling Pathway Ribonucleoprotein Complex Binding Positive Regulation Of Catabolic Process Macromolecule Metabolic Process
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