EIF2S1 and EIF2B4

Number of citations of the paper that reports this interaction (PubMedID 8887689)
29

Data Source:
HPRD (in vivo, in vitro)

		EIF2S1	EIF2B4
Description		eukaryotic translation initiation factor 2 subunit alpha	eukaryotic translation initiation factor 2B subunit delta
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GO Annotations	Cellular Component	Nucleus Cytoplasm Mitochondrion Cytosol Eukaryotic Translation Initiation Factor 2 Complex Cytoplasmic Stress Granule Membrane Eukaryotic 48S Preinitiation Complex Translation Initiation Ternary Complex Synapse Extracellular Exosome Glial Limiting End-foot	Cytoplasm Cytosol Eukaryotic Translation Initiation Factor 2B Complex
	Molecular Function	Nucleic Acid Binding RNA Binding Translation Initiation Factor Activity Protein Binding Ribosome Binding	Translation Initiation Factor Activity Guanyl-nucleotide Exchange Factor Activity Protein Binding Translation Initiation Factor Binding
	Biological Process	Mitophagy Translation Translational Initiation Regulation Of Translation Negative Regulation Of Translational Initiation In Response To Stress Stress Granule Assembly Cellular Response To Amino Acid Starvation Cellular Response To Oxidative Stress Cellular Response To Heat Cellular Response To UV Response To Endoplasmic Reticulum Stress Regulation Of Translation In Response To Endoplasmic Reticulum Stress PERK-mediated Unfolded Protein Response Regulation Of Translational Initiation In Response To Stress Mitochondrial Respirasome Assembly HRI-mediated Signaling Response To Kainic Acid Response To Manganese-induced Endoplasmic Reticulum Stress Positive Regulation Of Type B Pancreatic Cell Apoptotic Process	Ovarian Follicle Development Cytoplasmic Translational Initiation Translation Translational Initiation Regulation Of Translation Central Nervous System Development Response To Heat Response To Glucose Oligodendrocyte Development Myelination Response To Peptide Hormone Animal Organ Development T Cell Receptor Signaling Pathway
Pathways		L13a-mediated translational silencing of Ceruloplasmin expression PERK regulates gene expression PERK regulates gene expression ABC-family proteins mediated transport Translation initiation complex formation Formation of the ternary complex, and subsequently, the 43S complex Ribosomal scanning and start codon recognition GTP hydrolysis and joining of the 60S ribosomal subunit Recycling of eIF2:GDP Response of EIF2AK4 (GCN2) to amino acid deficiency Response of EIF2AK1 (HRI) to heme deficiency PKR-mediated signaling Cellular response to mitochondrial stress	Recycling of eIF2:GDP
Drugs
Diseases			Leukoencephalopathy with vanishing white matter; Vanishing white matter disease; Childhood ataxia with diffuse central nervous system hypomyelination (CACH); Cree leukoencephalopathy (CLE)
GWAS			Non-oily fish consumption ( 32066663)
Interacting Genes		28 interacting genes: ACTN1 ANXA1 CASP3 CASP6 CDC37 CEBPA CSNK2A1 EIF1AX EIF2AK1 EIF2AK2 EIF2AK3 EIF2B1 EIF2B2 EIF2B3 EIF2B4 EIF2S2 HSP90AA1 HSPB1 MELK P4HB PPP1R15A PRKCA PRKCD PRMT7 SFN TERT THAP12 VAC14	3 interacting genes: EIF2B2 EIF2S1 EIF2S2
Entrez ID		1965	8890
HPRD ID		04881	09459
Ensembl ID		ENSG00000134001	ENSG00000115211
Uniprot IDs		P05198 Q53XC0	B4DUP5 E7ERK9 F8W8L6 Q71US4 Q9HBP7 Q9UI10
PDB IDs		1KL9 1Q8K 6K71 6K72 6O81 6O85 6O9Z 6YBV 6ZMW 6ZP4 7A09 7D43 7D44 7D45 7F66 7F67 7NZM 7QP6 7QP7 7SYR 7SYS 8OZ0 8PJ1 8PJ2 8PJ3 8PJ4 8PPL 8QZZ	6CAJ 6EZO 6K71 6K72 6O81 6O85 6O9Z 7D43 7D44 7D45 7D46 7F64 7F66 7F67 7KMF 7L70 7L7G 7RLO 7TRJ 7VLK 8TQO 8TQZ
Enriched GO Terms of Interacting Partners?		Translational Initiation Eukaryotic Translation Initiation Factor 2B Complex Translation Initiation Factor Activity Cytosol Regulation Of Translational Initiation Response To Stress Post-transcriptional Regulation Of Gene Expression Cytoplasmic Translational Initiation Protein Metabolic Process Response To Temperature Stimulus Response To Heat Regulation Of Apoptotic Process Regulation Of Translation Regulation Of Programmed Cell Death Eukaryotic Translation Initiation Factor 2alpha Kinase Activity Regulation Of Protein Metabolic Process Response To Hormone Regulation Of Immune System Process Signal Transduction Oligodendrocyte Development Positive Regulation Of Immune System Process Intrinsic Apoptotic Signaling Pathway Macromolecule Metabolic Process Apoptotic Signaling Pathway Translation Protein Serine Kinase Activity Regulation Of Immune Response Intracellular Signal Transduction Response To Glucose Cellular Response To Stress Response To Monosaccharide Protein Serine/threonine Kinase Activity Glial Cell Development Activation Of Immune Response Translation Factor Activity, RNA Binding Response To Carbohydrate Cell Development Protein Kinase C Inhibitor Activity Positive Regulation Of Immune Response Identical Protein Binding Response To Peptide Hormone Cytoplasm Regulation Of Gene Expression Regulation Of Stem Cell Proliferation Negative Regulation Of Translation Protein Kinase Activity Regulation Of Macromolecule Biosynthetic Process Cellular Response To Staurosporine Protein Kinase C Signaling Protein Folding	Translation Initiation Factor Activity Translational Initiation Eukaryotic Translation Initiation Factor 2 Complex Translation Cytoplasmic Translational Initiation Response To Heat Regulation Of Translational Initiation Translation Initiation Ternary Complex Response To Temperature Stimulus Response To Manganese-induced Endoplasmic Reticulum Stress Glial Limiting End-foot Male Germ Cell Proliferation Macromolecule Biosynthetic Process Response To Kainic Acid Negative Regulation Of Translational Initiation In Response To Stress Positive Regulation Of Type B Pancreatic Cell Apoptotic Process Eukaryotic Translation Initiation Factor 2B Complex HRI-mediated Signaling Regulation Of Translation In Response To Endoplasmic Reticulum Stress Mitochondrial Respirasome Assembly Regulation Of Translational Initiation In Response To Stress Regulation Of Translation Cellular Response To Manganese Ion Formation Of Translation Preinitiation Complex PERK-mediated Unfolded Protein Response Response To Manganese Ion Eukaryotic 48S Preinitiation Complex Post-transcriptional Regulation Of Gene Expression Positive Regulation Of Epithelial Cell Apoptotic Process Regulation Of Translation In Response To Stress Translation Factor Activity, RNA Binding Translation Initiation Factor Binding Oligodendrocyte Development Protein Metabolic Process Stress Granule Assembly ER-nucleus Signaling Pathway Integrated Stress Response Signaling Negative Regulation Of Translational Initiation Ovarian Follicle Development Synapse Cellular Response To Heat Regulation Of Epithelial Cell Apoptotic Process Mitophagy Cellular Response To Amino Acid Starvation Response To Amino Acid Starvation Endoplasmic Reticulum Unfolded Protein Response Glial Cell Development Autophagy Of Mitochondrion Ribosome Binding
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