EIF2S1 and EIF2AK1

Number of citations of the paper that reports this interaction (PubMedID 9819435)
53

Data Source:
HPRD (in vivo)

		EIF2S1	EIF2AK1
Description		eukaryotic translation initiation factor 2 subunit alpha	eukaryotic translation initiation factor 2 alpha kinase 1
Image			No pdb structure
GO Annotations	Cellular Component	Nucleus Cytoplasm Mitochondrion Cytosol Eukaryotic Translation Initiation Factor 2 Complex Cytoplasmic Stress Granule Membrane Eukaryotic 48S Preinitiation Complex Translation Initiation Ternary Complex Synapse Extracellular Exosome Glial Limiting End-foot	Nucleus Cytoplasm Cytosol
	Molecular Function	Nucleic Acid Binding RNA Binding Translation Initiation Factor Activity Protein Binding Ribosome Binding	Nucleotide Binding Protein Kinase Activity Protein Serine/threonine Kinase Activity Eukaryotic Translation Initiation Factor 2alpha Kinase Activity Protein Binding ATP Binding Kinase Activity Transferase Activity Heme Binding Protein Homodimerization Activity Protein Serine Kinase Activity
	Biological Process	Mitophagy Translation Translational Initiation Regulation Of Translation Negative Regulation Of Translational Initiation In Response To Stress Stress Granule Assembly Cellular Response To Amino Acid Starvation Cellular Response To Oxidative Stress Cellular Response To Heat Cellular Response To UV Response To Endoplasmic Reticulum Stress Regulation Of Translation In Response To Endoplasmic Reticulum Stress PERK-mediated Unfolded Protein Response Regulation Of Translational Initiation In Response To Stress Mitochondrial Respirasome Assembly HRI-mediated Signaling Response To Kainic Acid Response To Manganese-induced Endoplasmic Reticulum Stress Positive Regulation Of Type B Pancreatic Cell Apoptotic Process	Mitophagy Acute Inflammatory Response Translational Initiation Regulation Of Translation Regulation Of Translational Initiation Phagocytosis Response To Stress Negative Regulation Of Cell Population Proliferation Negative Regulation Of Translation Macrophage Differentiation Negative Regulation Of Translational Initiation By Iron Protoporphyrinogen IX Metabolic Process Protein Autophosphorylation Regulation Of Hemoglobin Biosynthetic Process Negative Regulation Of Hemoglobin Biosynthetic Process Establishment Of Localization In Cell Multicellular Organismal-level Iron Ion Homeostasis Protein Localization To Mitochondrion Integrated Stress Response Signaling HRI-mediated Signaling Positive Regulation Of Mitophagy Response To Iron Ion Starvation
Pathways		L13a-mediated translational silencing of Ceruloplasmin expression PERK regulates gene expression PERK regulates gene expression ABC-family proteins mediated transport Translation initiation complex formation Formation of the ternary complex, and subsequently, the 43S complex Ribosomal scanning and start codon recognition GTP hydrolysis and joining of the 60S ribosomal subunit Recycling of eIF2:GDP Response of EIF2AK4 (GCN2) to amino acid deficiency Response of EIF2AK1 (HRI) to heme deficiency PKR-mediated signaling Cellular response to mitochondrial stress	Response of EIF2AK1 (HRI) to heme deficiency Cellular response to mitochondrial stress
Drugs			Fostamatinib
Diseases
GWAS			High light scatter reticulocyte count ( 27863252 32888494) High light scatter reticulocyte percentage of red cells ( 27863252 32888494) Mean corpuscular hemoglobin ( 32888494) Mean corpuscular volume ( 32888494) Reticulocyte count ( 27863252 32888494) Reticulocyte fraction of red cells ( 27863252 32888494)
Interacting Genes		28 interacting genes: ACTN1 ANXA1 CASP3 CASP6 CDC37 CEBPA CSNK2A1 EIF1AX EIF2AK1 EIF2AK2 EIF2AK3 EIF2B1 EIF2B2 EIF2B3 EIF2B4 EIF2S2 HSP90AA1 HSPB1 MELK P4HB PPP1R15A PRKCA PRKCD PRMT7 SFN TERT THAP12 VAC14	6 interacting genes: CDC37 EIF2S1 HSP90AA1 LCOR LIG4 SELENOS
Entrez ID		1965	27102
HPRD ID		04881	10684
Ensembl ID		ENSG00000134001	ENSG00000086232
Uniprot IDs		P05198 Q53XC0	Q9BQI3
PDB IDs		1KL9 1Q8K 6K71 6K72 6O81 6O85 6O9Z 6YBV 6ZMW 6ZP4 7A09 7D43 7D44 7D45 7F66 7F67 7NZM 7QP6 7QP7 7SYR 7SYS 8OZ0 8PJ1 8PJ2 8PJ3 8PJ4 8PPL 8QZZ
Enriched GO Terms of Interacting Partners?		Translational Initiation Eukaryotic Translation Initiation Factor 2B Complex Translation Initiation Factor Activity Cytosol Regulation Of Translational Initiation Response To Stress Post-transcriptional Regulation Of Gene Expression Cytoplasmic Translational Initiation Protein Metabolic Process Response To Temperature Stimulus Response To Heat Regulation Of Apoptotic Process Regulation Of Translation Regulation Of Programmed Cell Death Eukaryotic Translation Initiation Factor 2alpha Kinase Activity Regulation Of Protein Metabolic Process Response To Hormone Regulation Of Immune System Process Signal Transduction Oligodendrocyte Development Positive Regulation Of Immune System Process Intrinsic Apoptotic Signaling Pathway Macromolecule Metabolic Process Apoptotic Signaling Pathway Translation Protein Serine Kinase Activity Regulation Of Immune Response Intracellular Signal Transduction Response To Glucose Cellular Response To Stress Response To Monosaccharide Protein Serine/threonine Kinase Activity Glial Cell Development Activation Of Immune Response Translation Factor Activity, RNA Binding Response To Carbohydrate Cell Development Protein Kinase C Inhibitor Activity Positive Regulation Of Immune Response Identical Protein Binding Response To Peptide Hormone Cytoplasm Regulation Of Gene Expression Regulation Of Stem Cell Proliferation Negative Regulation Of Translation Protein Kinase Activity Regulation Of Macromolecule Biosynthetic Process Cellular Response To Staurosporine Protein Kinase C Signaling Protein Folding	Ubiquitin-specific Protease Binding ER-nucleus Signaling Pathway Protein Folding Chaperone Complex Regulation Of Programmed Cell Death Regulation Of Apoptotic Process Endoplasmic Reticulum Unfolded Protein Response Response To Heat Translation Initiation Ternary Complex Cellular Response To Heat DNA Biosynthetic Process Unfolded Protein Binding CTP Binding DATP Binding Regulation Of Nitric Oxide Metabolic Process Neurofibrillary Tangle Assembly Positive Regulation Of Chromosome Organization UTP Binding Scaffold Protein Binding Sulfonylurea Receptor Binding Establishment Of Integrated Proviral Latency Establishment Of Viral Latency HSP90-CDC37 Chaperone Complex Derlin-1-VIMP Complex Response To Manganese-induced Endoplasmic Reticulum Stress Glial Limiting End-foot Cellular Response To Stress Rho GDP-dissociation Inhibitor Binding Histone Deacetylase Binding DNA Ligase (ATP) Activity DNA Ligase IV Complex DNA Ligase Activity Response To Temperature Stimulus Response To Kainic Acid Eukaryotic Translation Initiation Factor 2 Complex Pro-B Cell Differentiation T Cell Receptor V(D)J Recombination DN2 Thymocyte Differentiation Cellular Response To Radiation Cellular Response To Metal Ion Negative Regulation Of Translational Initiation In Response To Stress Positive Regulation Of Type B Pancreatic Cell Apoptotic Process Sperm Mitochondrial Sheath Protein Folding Regulation Of Defense Response Telomerase Holoenzyme Complex Assembly Nucleotide-excision Repair, DNA Gap Filling Negative Regulation Of Acute Inflammatory Response To Antigenic Stimulus Cellular Response To Oxidative Stress HRI-mediated Signaling Response To Endoplasmic Reticulum Stress
Tagcloud ?
Tagcloud (Difference) ?
Tagcloud (Intersection) ?