EIF1AX and EIF5

Number of citations of the paper that reports this interaction (PubMedID 10982835)
45

Data Source:
HPRD (in vitro, in vivo)

		EIF1AX	EIF5
Description		eukaryotic translation initiation factor 1A X-linked	eukaryotic translation initiation factor 5
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GO Annotations	Cellular Component	Cytoplasm Cytosol Eukaryotic 43S Preinitiation Complex Eukaryotic 48S Preinitiation Complex Multi-eIF Complex Synapse	Nucleus Cytoplasm Cytosol Plasma Membrane Synapse
	Molecular Function	TRNA Binding RNA Binding Translation Initiation Factor Activity Protein Binding Translation Factor Activity, RNA Binding	Nucleotide Binding RNA Binding Translation Initiation Factor Activity GDP-dissociation Inhibitor Activity GTPase Activator Activity Protein Binding GTP Binding Cadherin Binding Eukaryotic Initiation Factor EIF2 Binding
	Biological Process	Translation Translational Initiation Ribosome Assembly	Formation Of Cytoplasmic Translation Initiation Complex Translation Translational Initiation Regulation Of Translational Initiation Ribosome Assembly
Pathways		L13a-mediated translational silencing of Ceruloplasmin expression Translation initiation complex formation Formation of a pool of free 40S subunits Formation of the ternary complex, and subsequently, the 43S complex Ribosomal scanning and start codon recognition GTP hydrolysis and joining of the 60S ribosomal subunit	Ribosomal scanning and start codon recognition GTP hydrolysis and joining of the 60S ribosomal subunit
Drugs
Diseases
GWAS			Autism spectrum disorder or schizophrenia ( 28540026) Body mass index ( 26426971) Monocyte count ( 29403010) Number of sexual partners ( 30643258) Red blood cell traits ( 23222517)
Interacting Genes		9 interacting genes: APP EIF2S1 EIF3C EIF5 EIF5B HSPB1 IKBKG IPO13 RFPL3	18 interacting genes: APP CDC42 CEBPA CSNK2A1 CSNK2B DUSP12 EIF1AX EIF1AY EIF2S2 EIF3D EIF3G EIF4G1 EIF4G2 HSPB1 NCBP2 NRGN OGT PUM1
Entrez ID		1964	1983
HPRD ID		02174	03417
Ensembl ID		ENSG00000173674	ENSG00000100664
Uniprot IDs		P47813	P55010
PDB IDs		1D7Q 3ZJY 4KZY 4KZZ 6YBW 6ZMW 6ZP4 7A09 7QP6 7QP7 7SYQ 7SYR 7SYS 7SYV 7SYW 7SYX 7TQL 8OZ0 8PJ1 8PJ2 8PJ3 8PJ4 8PJ5 8PJ6 8PPL	2E9H 2G2K 2IU1 8OZ0 8PJ2 8PJ3
Enriched GO Terms of Interacting Partners?		Translation Initiation Factor Activity Regulation Of Translation Translational Initiation Post-transcriptional Regulation Of Gene Expression Regulation Of Translational Initiation Regulation Of Protein Metabolic Process Cellular Response To Manganese Ion Response To Manganese Ion Translation Formation Of Cytoplasmic Translation Initiation Complex Eukaryotic 48S Preinitiation Complex Ribosome Assembly Regulation Of Intrinsic Apoptotic Signaling Pathway Regulation Of Endoplasmic Reticulum Stress-induced Intrinsic Apoptotic Signaling Pathway Regulation Of Gene Expression Protein-containing Complex Assembly Regulation Of Macromolecule Biosynthetic Process Cytoplasm Membraneless Organelle Assembly Protein-containing Complex Organization Amyloid-beta Complex Growth Cone Lamellipodium Regulation Of Response To Calcium Ion Amylin Binding Cellular Component Assembly Positive Regulation Of Toll Signaling Pathway Positive Regulation Of Interleukin-1 Beta Production Translation Initiation Ternary Complex RNA Binding Negative Regulation Of Protein Kinase C Signaling Positive Regulation Of Interleukin-1 Production Regulation Of Macromolecule Metabolic Process Ribosome Binding Axo-dendritic Transport Regulation Of Apoptotic Signaling Pathway Synapse Response To Heat Acetylcholine Receptor Activator Activity Regulation Of Response To Endoplasmic Reticulum Stress Lipoprotein Particle Positive Regulation Of Protein Import PTB Domain Binding Collateral Sprouting In Absence Of Injury Regulation Of Protein Import Regulation Of Interleukin-1 Production Positive Regulation Of Tumor Necrosis Factor Production Endosome To Plasma Membrane Transport Vesicle Positive Regulation Of Endothelin Production Growth Cone Filopodium Regulation Of Metabolic Process	Translational Initiation Translation Initiation Factor Activity Cytoplasmic Translational Initiation Regulation Of Translational Initiation Translation Regulation Of Translation Translation Factor Activity, RNA Binding Cap-dependent Translational Initiation Post-transcriptional Regulation Of Gene Expression Macromolecule Biosynthetic Process Regulation Of Protein Metabolic Process Cytosol RNA Binding Eukaryotic 43S Preinitiation Complex Eukaryotic 48S Preinitiation Complex Protein Kinase CK2 Complex Symbiont-mediated Disruption Of Host Cell PML Body Protein Metabolic Process Viral Translational Termination-reinitiation Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Negative Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Macromolecule Metabolic Process Positive Regulation Of Cell Growth Regulation Of Ubiquitin-dependent Protein Catabolic Process Regulation Of Protein Catabolic Process Regulation Of Proteolysis Negative Regulation Of Proteasomal Protein Catabolic Process Negative Regulation Of Catabolic Process Negative Regulation Of Ubiquitin-dependent Protein Catabolic Process Regulation Of Proteasomal Protein Catabolic Process Regulation Of Cell Cycle Negative Regulation Of Proteolysis Involved In Protein Catabolic Process Eukaryotic Translation Initiation Factor 4F Complex Formation Of Cytoplasmic Translation Initiation Complex Eukaryotic Translation Initiation Factor 3 Complex Positive Regulation Of Growth MRNA Binding Regulation Of Synapse Organization Sin3-type Complex Translation Initiation Factor Binding Positive Regulation Of Long-term Synaptic Potentiation Negative Regulation Of Protein Catabolic Process Cellular Component Assembly Regulation Of Growth Regulation Of Presynapse Organization Regulation Of Presynapse Assembly PcG Protein Complex Post-transcriptional Gene Silencing Negative Regulation Of Proteolysis Viral Process
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