DUSP3 and EGF

Number of citations of the paper that reports this interaction (PubMedID 1281549)
38

Data Source:
HPRD (in vitro)

		DUSP3	EGF
Description		dual specificity phosphatase 3	epidermal growth factor
Image
GO Annotations	Cellular Component	Immunological Synapse Nucleus Nucleoplasm Cytoplasm Cytosol Cytoskeleton Cilium Motile Cilium Cell Projection	Extracellular Region Extracellular Space Lysosomal Membrane Plasma Membrane Membrane Clathrin-coated Endocytic Vesicle Membrane Platelet Alpha Granule Lumen Extracellular Exosome
	Molecular Function	Phosphoprotein Phosphatase Activity Protein Serine/threonine Phosphatase Activity Protein Tyrosine Phosphatase Activity Protein Binding Cytoskeletal Protein Binding Protein Tyrosine/serine/threonine Phosphatase Activity Hydrolase Activity Phosphatase Activity Protein Kinase Binding Receptor Signaling Protein Tyrosine Kinase Inhibitor Activity Receptor Tyrosine Kinase Binding MAP Kinase Phosphatase Activity Protein Tyrosine Kinase Binding	Guanyl-nucleotide Exchange Factor Activity Epidermal Growth Factor Receptor Binding Calcium Ion Binding Protein Binding Growth Factor Activity Transmembrane Receptor Protein Tyrosine Kinase Activator Activity Receptor Ligand Activity
	Biological Process	Negative Regulation Of Signal Transduction Dephosphorylation Negative Regulation Of Cell Migration Peptidyl-tyrosine Dephosphorylation Negative Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Negative Regulation Of MAPK Cascade Positive Regulation Of Mitotic Cell Cycle Negative Regulation Of JNK Cascade Negative Regulation Of T Cell Receptor Signaling Pathway Negative Regulation Of T Cell Activation Negative Regulation Of Chemotaxis Regulation Of Focal Adhesion Assembly Negative Regulation Of ERK1 And ERK2 Cascade Cellular Response To Epidermal Growth Factor Stimulus Positive Regulation Of Focal Adhesion Disassembly	Angiogenesis Positive Regulation Of Endothelial Cell Proliferation Positive Regulation Of Receptor Internalization Epidermal Growth Factor Receptor Signaling Pathway Cell Population Proliferation Positive Regulation Of Cell Population Proliferation Positive Regulation Of Endothelial Cell Migration Positive Regulation Of Macromolecule Metabolic Process Positive Regulation Of Gene Expression Positive Regulation Of Peptidyl-threonine Phosphorylation Cerebellar Granule Cell Precursor Proliferation Positive Regulation Of Cerebellar Granule Cell Precursor Proliferation Positive Regulation Of Cell Migration ERBB2-EGFR Signaling Pathway Positive Regulation Of Phosphorylation Positive Regulation Of DNA Binding Positive Regulation Of MAPK Cascade Positive Regulation Of Mitotic Nuclear Division Positive Regulation Of DNA-templated Transcription Regulation Of Receptor Signaling Pathway Via JAK-STAT System Development Branching Morphogenesis Of An Epithelial Tube Epithelial Cell Proliferation Positive Regulation Of Epithelial Cell Proliferation Negative Regulation Of Secretion Regulation Of Transport Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Mammary Gland Alveolus Development ERK1 And ERK2 Cascade Regulation Of Primary Metabolic Process Positive Regulation Of Canonical Wnt Signaling Pathway Regulation Of Calcium Ion Import Negative Regulation Of Cholesterol Efflux Positive Regulation Of Hyaluronan Biosynthetic Process Positive Regulation Of Protein Localization To Early Endosome Positive Regulation Of Epithelial Tube Formation Regulation Of Protein Localization To Cell Surface Positive Regulation Of Ubiquitin-dependent Protein Catabolic Process
Pathways		ERKs are inactivated	Platelet degranulation Signaling by ERBB2 Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants Signaling by ERBB4 SHC1 events in ERBB2 signaling SHC1 events in ERBB2 signaling PLCG1 events in ERBB2 signaling PIP3 activates AKT signaling Signaling by EGFR Signaling by EGFR GRB2 events in EGFR signaling GAB1 signalosome SHC1 events in EGFR signaling EGFR downregulation GRB2 events in ERBB2 signaling PI3K events in ERBB2 signaling EGFR interacts with phospholipase C-gamma Constitutive Signaling by Aberrant PI3K in Cancer Constitutive Signaling by EGFRvIII Inhibition of Signaling by Overexpressed EGFR RAF/MAP kinase cascade ERBB2 Regulates Cell Motility PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling ERBB2 Activates PTK6 Signaling Cargo recognition for clathrin-mediated endocytosis Clathrin-mediated endocytosis Downregulation of ERBB2 signaling Extra-nuclear estrogen signaling NOTCH3 Activation and Transmission of Signal to the Nucleus Estrogen-dependent nuclear events downstream of ESR-membrane signaling Signaling by ERBB2 KD Mutants Signaling by ERBB2 ECD mutants Signaling by ERBB2 TMD/JMD mutants Differentiation of Keratinocytes in Interfollicular Epidermis in Mammalian Skin NFE2L2 regulating tumorigenic genes Developmental Lineage of Mammary Gland Luminal Epithelial Cells Developmental Lineage of Mammary Gland Myoepithelial Cells Developmental Lineage of Multipotent Pancreatic Progenitor Cells
Drugs			Sucralfate Alpha-Aminobutyric Acid Cholecystokinin Tesevatinib Oleandrin
Diseases			Gastric cancer
GWAS		Fractures ( 30158200) HDL cholesterol ( 25961943 27036123) High density lipoprotein cholesterol levels ( 33339817) Metabolite levels ( 23823483) Triglycerides ( 25961943)	Albumin-globulin ratio ( 29403010) Blood protein levels ( 30072576) Glycated hemoglobin levels ( 34059833) Hair morphology ( 19896111) High light scatter reticulocyte count ( 32888494) High light scatter reticulocyte percentage of red cells ( 32888494) Lymphocyte count ( 32888494) Mean corpuscular hemoglobin concentration ( 32888494) Mean corpuscular volume ( 29403010) Mean spheric corpuscular volume ( 32888494) Monocyte count ( 32888494) Monocyte percentage of white cells ( 32888494) Neutrophil percentage of white cells ( 32888494) Non-albumin protein levels ( 29403010) Platelet count ( 32888494 33545615 27863252 29403010) Platelet distribution width ( 32888494) Plateletcrit ( 32888494 27863252) Reticulocyte count ( 32888494 27863252) Reticulocyte fraction of red cells ( 27863252 32888494) Spleen volume ( 34128465) Waist-to-hip ratio adjusted for BMI ( 28552196)
Interacting Genes		15 interacting genes: APP BNIP3L CASK EGF EGFR FGF7 MAP2K2 MAPK1 MAPK3 MEOX1 NEUROD1 PDGFA STAT1 SYK ZAP70	14 interacting genes: ADAM12 CPM DUSP3 EGFR ERBB2 ERBB3 GRB2 GRK2 LMNA MGST1 NRG1 PIK3R1 PIK3R2 VTN
Entrez ID		1845	1950
HPRD ID		02553	00578
Ensembl ID		ENSG00000108861	ENSG00000138798
Uniprot IDs		P51452	A0A494C018 P01133
PDB IDs		1J4X 1VHR 3F81 8TK2 8TK3 8TK4 8TK5 8TK6 9DJ9	1IVO 1JL9 1NQL 1P9J 2KV4 3NJP 7OM4 7SYD 7SYE 7SZ0 7SZ1 8HGO 8HGS
Enriched GO Terms of Interacting Partners?		Regulation Of MAPK Cascade ERBB2 Signaling Pathway Positive Regulation Of Metabolic Process Positive Regulation Of MAPK Cascade Cell Surface Receptor Signaling Pathway Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Regulation Of Golgi Inheritance Positive Regulation Of Phosphate Metabolic Process ERBB Signaling Pathway Regulation Of Cell Population Proliferation Positive Regulation Of Cell Motility Positive Regulation Of Locomotion Positive Regulation Of Cell Communication Positive Regulation Of Signaling Positive Regulation Of Cell Population Proliferation Positive Regulation Of Macromolecule Metabolic Process Trachea Formation Enzyme-linked Receptor Protein Signaling Pathway Positive Regulation Of Protein Phosphorylation Anatomical Structure Morphogenesis Positive Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Intracellular Signal Transduction Positive Regulation Of Phosphorylation ERBB3 Signaling Pathway ERBB2-ERBB3 Signaling Pathway Positive Regulation Of Biosynthetic Process Regulation Of Cell Communication Regulation Of Signaling Phosphotyrosine Residue Binding Protein Kinase Activity Positive Regulation Of Protein Metabolic Process ERK1 And ERK2 Cascade Animal Organ Morphogenesis Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Vesicle-mediated Transport Intracellular Signaling Cassette Regulation Of Multicellular Organismal Process Positive Regulation Of Cell Migration Regulation Of Phosphorus Metabolic Process Regulation Of Signal Transduction Glial Cell Development Epidermal Growth Factor Receptor Signaling Pathway Positive Regulation Of RNA Metabolic Process Epithelial Cell Proliferation Regulation Of Developmental Process Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of Golgi Organization	ErbB-3 Class Receptor Binding ERBB Signaling Pathway ERBB2 Signaling Pathway Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway ERBB2-ERBB3 Signaling Pathway ERBB3 Signaling Pathway Regulation Of Cell Adhesion Receptor Tyrosine Kinase Binding Epidermal Growth Factor Receptor Signaling Pathway Protein Tyrosine Kinase Activator Activity Regulation Of MAPK Cascade Enzyme-linked Receptor Protein Signaling Pathway Schwann Cell Development ERBB3:ERBB2 Complex Regulation Of Multicellular Organismal Process Protein Phosphatase Binding Regulation Of Signal Transduction Peripheral Nervous System Development Regulation Of Cell Communication Regulation Of Signaling ERBB2-ERBB4 Signaling Pathway Cellular Response To Epidermal Growth Factor Stimulus Phosphotyrosine Residue Binding Response To Epidermal Growth Factor Neurotrophin TRKA Receptor Binding 1-phosphatidylinositol-3-kinase Regulator Activity Negative Regulation Of Multicellular Organismal Process Positive Regulation Of Focal Adhesion Disassembly ERBB2-EGFR Signaling Pathway Glial Cell Development Basal Plasma Membrane Developmental Process ERBB4 Signaling Pathway Phosphatidylinositol 3-kinase Complex, Class IA Phosphatidylinositol 3-kinase Regulatory Subunit Binding Regulation Of Cellular Component Organization Wound Healing Intracellular Signaling Cassette Negative Regulation Of Apoptotic Process Positive Regulation Of Cell Adhesion Insulin Receptor Signaling Pathway Negative Regulation Of Programmed Cell Death Negative Regulation Of Signal Transduction Animal Organ Development Cell Surface Receptor Signaling Pathway Insulin Receptor Substrate Binding Regulation Of Intracellular Signal Transduction Myelination Axon Ensheathment
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