EGF and NRG1

Number of citations of the paper that reports this interaction (PubMedID 7730382)
0

Data Source:
HPRD (in vitro)

		EGF	NRG1
Description		epidermal growth factor	neuregulin 1
Image
GO Annotations	Cellular Component	Extracellular Region Extracellular Space Lysosomal Membrane Plasma Membrane Membrane Clathrin-coated Endocytic Vesicle Membrane Platelet Alpha Granule Lumen Extracellular Exosome	Extracellular Region Extracellular Space Nucleus Nucleoplasm Plasma Membrane Membrane Apical Plasma Membrane Glutamatergic Synapse
	Molecular Function	Guanyl-nucleotide Exchange Factor Activity Epidermal Growth Factor Receptor Binding Calcium Ion Binding Protein Binding Growth Factor Activity Transmembrane Receptor Protein Tyrosine Kinase Activator Activity Receptor Ligand Activity	Transcription Coregulator Activity Signaling Receptor Binding Cytokine Activity Integrin Binding Protein Binding Growth Factor Activity Zinc Ion Binding Nickel Cation Binding Protein Tyrosine Kinase Activator Activity Transmembrane Receptor Protein Tyrosine Kinase Activator Activity Receptor Tyrosine Kinase Binding ErbB-3 Class Receptor Binding Chemorepellent Activity Receptor Ligand Activity
	Biological Process	Angiogenesis Positive Regulation Of Endothelial Cell Proliferation Positive Regulation Of Receptor Internalization Epidermal Growth Factor Receptor Signaling Pathway Cell Population Proliferation Positive Regulation Of Cell Population Proliferation Positive Regulation Of Endothelial Cell Migration Positive Regulation Of Macromolecule Metabolic Process Positive Regulation Of Gene Expression Positive Regulation Of Peptidyl-threonine Phosphorylation Cerebellar Granule Cell Precursor Proliferation Positive Regulation Of Cerebellar Granule Cell Precursor Proliferation Positive Regulation Of Cell Migration ERBB2-EGFR Signaling Pathway Positive Regulation Of Phosphorylation Positive Regulation Of DNA Binding Positive Regulation Of MAPK Cascade Positive Regulation Of Mitotic Nuclear Division Positive Regulation Of DNA-templated Transcription Regulation Of Receptor Signaling Pathway Via JAK-STAT System Development Branching Morphogenesis Of An Epithelial Tube Epithelial Cell Proliferation Positive Regulation Of Epithelial Cell Proliferation Negative Regulation Of Secretion Regulation Of Transport Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Mammary Gland Alveolus Development ERK1 And ERK2 Cascade Regulation Of Primary Metabolic Process Positive Regulation Of Canonical Wnt Signaling Pathway Regulation Of Calcium Ion Import Negative Regulation Of Cholesterol Efflux Positive Regulation Of Hyaluronan Biosynthetic Process Positive Regulation Of Protein Localization To Early Endosome Positive Regulation Of Epithelial Tube Formation Regulation Of Protein Localization To Cell Surface Positive Regulation Of Ubiquitin-dependent Protein Catabolic Process	Ventricular Trabecula Myocardium Morphogenesis Cell Communication Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Nervous System Development Brain Development Peripheral Nervous System Development Cell Population Proliferation Positive Regulation Of Cell Population Proliferation Regulation Of Cell Communication Negative Regulation Of Cardiac Muscle Cell Apoptotic Process Neural Crest Cell Development Regulation Of Signaling Cell Differentiation Positive Regulation Of Cell Growth Mammary Gland Development Positive Regulation Of Protein-containing Complex Assembly Activation Of Protein Kinase B Activity Intracellular Signal Transduction ERBB Signaling Pathway ERBB2 Signaling Pathway ERBB3 Signaling Pathway ERBB4 Signaling Pathway ERBB2-ERBB3 Signaling Pathway ERBB2-ERBB4 Signaling Pathway ERBB4-ERBB4 Signaling Pathway Wound Healing Positive Regulation Of Cell Adhesion Negative Regulation Of DNA-templated Transcription Negative Chemotaxis Negative Regulation Of Secretion Positive Regulation Of Developmental Process Positive Regulation Of Striated Muscle Cell Differentiation Cardiac Muscle Cell Differentiation Ventricular Cardiac Muscle Cell Differentiation Positive Regulation Of Cardiac Muscle Cell Proliferation Cardiac Muscle Cell Myoblast Differentiation Endocardial Cell Differentiation Regulation Of Biological Quality Positive Regulation Of ERK1 And ERK2 Cascade Regulation Of Postsynaptic Neurotransmitter Receptor Internalization Positive Regulation Of Peptidyl-tyrosine Autophosphorylation Negative Regulation Of Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand
Pathways		Platelet degranulation Signaling by ERBB2 Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants Signaling by ERBB4 SHC1 events in ERBB2 signaling SHC1 events in ERBB2 signaling PLCG1 events in ERBB2 signaling PIP3 activates AKT signaling Signaling by EGFR Signaling by EGFR GRB2 events in EGFR signaling GAB1 signalosome SHC1 events in EGFR signaling EGFR downregulation GRB2 events in ERBB2 signaling PI3K events in ERBB2 signaling EGFR interacts with phospholipase C-gamma Constitutive Signaling by Aberrant PI3K in Cancer Constitutive Signaling by EGFRvIII Inhibition of Signaling by Overexpressed EGFR RAF/MAP kinase cascade ERBB2 Regulates Cell Motility PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling ERBB2 Activates PTK6 Signaling Cargo recognition for clathrin-mediated endocytosis Clathrin-mediated endocytosis Downregulation of ERBB2 signaling Extra-nuclear estrogen signaling NOTCH3 Activation and Transmission of Signal to the Nucleus Estrogen-dependent nuclear events downstream of ESR-membrane signaling Signaling by ERBB2 KD Mutants Signaling by ERBB2 ECD mutants Signaling by ERBB2 TMD/JMD mutants Differentiation of Keratinocytes in Interfollicular Epidermis in Mammalian Skin NFE2L2 regulating tumorigenic genes Developmental Lineage of Mammary Gland Luminal Epithelial Cells Developmental Lineage of Mammary Gland Myoepithelial Cells Developmental Lineage of Multipotent Pancreatic Progenitor Cells	Signaling by ERBB2 Signaling by ERBB4 SHC1 events in ERBB2 signaling SHC1 events in ERBB2 signaling PI3K events in ERBB4 signaling SHC1 events in ERBB4 signaling Nuclear signaling by ERBB4 PIP3 activates AKT signaling GRB7 events in ERBB2 signaling Downregulation of ERBB2:ERBB3 signaling GRB2 events in ERBB2 signaling PI3K events in ERBB2 signaling Constitutive Signaling by Aberrant PI3K in Cancer RAF/MAP kinase cascade ERBB2 Regulates Cell Motility PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling ERBB2 Activates PTK6 Signaling Downregulation of ERBB2 signaling Long-term potentiation Signaling by ERBB2 KD Mutants Signaling by ERBB2 TMD/JMD mutants
Drugs		Sucralfate Alpha-Aminobutyric Acid Cholecystokinin Tesevatinib Oleandrin
Diseases		Gastric cancer
GWAS		Albumin-globulin ratio ( 29403010) Blood protein levels ( 30072576) Glycated hemoglobin levels ( 34059833) Hair morphology ( 19896111) High light scatter reticulocyte count ( 32888494) High light scatter reticulocyte percentage of red cells ( 32888494) Lymphocyte count ( 32888494) Mean corpuscular hemoglobin concentration ( 32888494) Mean corpuscular volume ( 29403010) Mean spheric corpuscular volume ( 32888494) Monocyte count ( 32888494) Monocyte percentage of white cells ( 32888494) Neutrophil percentage of white cells ( 32888494) Non-albumin protein levels ( 29403010) Platelet count ( 32888494 33545615 27863252 29403010) Platelet distribution width ( 32888494) Plateletcrit ( 32888494 27863252) Reticulocyte count ( 32888494 27863252) Reticulocyte fraction of red cells ( 27863252 32888494) Spleen volume ( 34128465) Waist-to-hip ratio adjusted for BMI ( 28552196)	Bone mineral density (hip) ( 30172743) Cardiac Troponin-T levels ( 23247143) Cerebrospinal P-tau181p levels ( 28247064) Cerebrospinal T-tau levels ( 28247064) Chin dimples ( 27182965) Chronotype ( 30696823) Cognitive function ( 25644384) Coronary artery calcification ( 23870195) Dialysis-related mortality ( 21546767) Differentiated thyroid cancer ( 28703219) Diffusing capacity of carbon monoxide ( 30694715) Emphysema imaging phenotypes ( 26030696) Estimated glomerular filtration rate ( 31152163 30604766) Gut microbiota alpha diversity (PD_whole_tree index) ( 33208821) Hematocrit ( 32888494) Hemoglobin ( 32888494) Hip geometry ( 17903296) Hirschsprung disease ( 19196962 27702942 25310821) Hypothyroidism ( 27182965) Logical memory (delayed recall) in mild cognitive impairment ( 29274321) Logical memory (immediate recall) in mild cognitive impairment ( 29274321) Lung adenocarcinoma ( 28604730) Lung cancer ( 28604730) Major depressive disorder ( 29317602) Malaria ( 31844061) Metabolite levels (X-11787) ( 23934736) Morning person ( 30696823) Non-small cell lung cancer ( 31326317) Obstructive sleep apnea ( 25325441) Papillary thyroid cancer ( 28703219) Post bronchodilator FEV1/FVC ratio in COPD ( 26634245) Pulse pressure ( 27841878) Refractive astigmatism ( 25367360) Response to serotonin reuptake inhibitors in major depressive disorder ( 25897834) Rheumatic heart disease ( 34106200) Serum thyroid-stimulating hormone levels ( 25436638) Thyroid cancer ( 22267200) Thyroid hormone levels ( 23408906) Thyroid stimulating hormone levels ( 32769997) Urate levels ( 31578528) Weight ( 28552196)
Interacting Genes		14 interacting genes: ADAM12 CPM DUSP3 EGFR ERBB2 ERBB3 GRB2 GRK2 LMNA MGST1 NRG1 PIK3R1 PIK3R2 VTN	15 interacting genes: ADAM19 ASGR2 CD72 EGF EGFR ERBB2 ERBB3 ERBB4 IKZF4 JAGN1 LAPTM4B LIMK1 MS4A4A PLP1 TMEM54
Entrez ID		1950	3084
HPRD ID		00578	00802
Ensembl ID		ENSG00000138798	ENSG00000157168
Uniprot IDs		A0A494C018 P01133	A0A024QY88 A0A494C0K4 A0A494C0L9 A0A494C0Q4 A0A494C114 A0A494C1B5 A0A494C1F5 A0A494C1F8 A5YAK6 A5YAK8 A6MW54 A6MW55 A6MW56 B0FWZ3 B0FYA7 B0FYA8 B0FYA9 B7Z1D7 B7Z1E3 E3SFM9 E5RHP6 Q02297 Q6PK61 Q7RTW3 Q7RTW5
PDB IDs		1IVO 1JL9 1NQL 1P9J 2KV4 3NJP 7OM4 7SYD 7SYE 7SZ0 7SZ1 8HGO 8HGS	1HAE 1HAF 1HRE 1HRF 3U7U 7MN5 7MN6 7MN8 7SJL 8U4I 8U4L
Enriched GO Terms of Interacting Partners?		ErbB-3 Class Receptor Binding ERBB Signaling Pathway ERBB2 Signaling Pathway Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway ERBB2-ERBB3 Signaling Pathway ERBB3 Signaling Pathway Regulation Of Cell Adhesion Receptor Tyrosine Kinase Binding Epidermal Growth Factor Receptor Signaling Pathway Protein Tyrosine Kinase Activator Activity Regulation Of MAPK Cascade Enzyme-linked Receptor Protein Signaling Pathway Schwann Cell Development ERBB3:ERBB2 Complex Regulation Of Multicellular Organismal Process Protein Phosphatase Binding Regulation Of Signal Transduction Peripheral Nervous System Development Regulation Of Cell Communication Regulation Of Signaling ERBB2-ERBB4 Signaling Pathway Cellular Response To Epidermal Growth Factor Stimulus Phosphotyrosine Residue Binding Response To Epidermal Growth Factor Neurotrophin TRKA Receptor Binding 1-phosphatidylinositol-3-kinase Regulator Activity Negative Regulation Of Multicellular Organismal Process Positive Regulation Of Focal Adhesion Disassembly ERBB2-EGFR Signaling Pathway Glial Cell Development Basal Plasma Membrane Developmental Process ERBB4 Signaling Pathway Phosphatidylinositol 3-kinase Complex, Class IA Phosphatidylinositol 3-kinase Regulatory Subunit Binding Regulation Of Cellular Component Organization Wound Healing Intracellular Signaling Cassette Negative Regulation Of Apoptotic Process Positive Regulation Of Cell Adhesion Insulin Receptor Signaling Pathway Negative Regulation Of Programmed Cell Death Negative Regulation Of Signal Transduction Animal Organ Development Cell Surface Receptor Signaling Pathway Insulin Receptor Substrate Binding Regulation Of Intracellular Signal Transduction Myelination Axon Ensheathment	ERBB2 Signaling Pathway Epidermal Growth Factor Receptor Signaling Pathway ERBB Signaling Pathway ERBB2-EGFR Signaling Pathway Positive Regulation Of Epithelial Cell Proliferation Transmembrane Receptor Protein Tyrosine Kinase Activity Protein Tyrosine Kinase Activity Basal Plasma Membrane ERBB3:ERBB2 Complex Receptor Complex Epidermal Growth Factor Receptor Activity Neuregulin Receptor Activity Regulation Of Epithelial Cell Proliferation Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Transmembrane Signaling Receptor Activity Positive Regulation Of Protein Phosphorylation Cell Surface Receptor Signaling Pathway Positive Regulation Of Phosphorylation Positive Regulation Of Growth ErbB-3 Class Receptor Binding ERBB2-ERBB4 Signaling Pathway Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Positive Regulation Of MAPK Cascade Cellular Response To Epidermal Growth Factor Stimulus Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Protein Kinase Activity Peptidyl-tyrosine Phosphorylation Response To Epidermal Growth Factor Positive Regulation Of Phosphate Metabolic Process ERBB2-ERBB3 Signaling Pathway ERBB3 Signaling Pathway ERBB4 Signaling Pathway Salivary Gland Morphogenesis Glial Cell Development Intracellular Signaling Cassette Positive Regulation Of Protein Modification Process Kinase Activity Regulation Of Protein Phosphorylation Enzyme-linked Receptor Protein Signaling Pathway Regulation Of MAPK Cascade Protein Tyrosine Kinase Activator Activity Regulation Of Phosphorylation Mammary Gland Alveolus Development Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction System Development Basolateral Plasma Membrane Schwann Cell Development Neurotransmitter Receptor Localization To Postsynaptic Specialization Membrane Myelination Axon Ensheathment
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