DTNA and SYNC

Number of citations of the paper that reports this interaction (PubMedID 11053421)
0

Data Source:
HPRD (two hybrid, in vitro, in vivo)

		DTNA	SYNC
Description		dystrobrevin alpha	syncoilin, intermediate filament protein
Image			No pdb structure
GO Annotations	Cellular Component	Nucleoplasm Cytoplasm Plasma Membrane Membrane Cell Junction Axon Extrinsic Component Of Cytoplasmic Side Of Plasma Membrane Protein-containing Complex Sarcolemma Cell Projection Intermediate Filament Cytoskeleton Synapse	Cytoplasm Cytosol Intermediate Filament Z Disc Neuromuscular Junction Sarcolemma Perinuclear Region Of Cytoplasm
	Molecular Function	Protein Binding Zinc Ion Binding PDZ Domain Binding Metal Ion Binding	Protein Binding
	Biological Process	Striated Muscle Contraction Signal Transduction Chemical Synaptic Transmission Neuromuscular Synaptic Transmission Synaptic Signaling	Intermediate Filament-based Process
Pathways		Formation of the dystrophin-glycoprotein complex (DGC) Formation of the dystrophin-glycoprotein complex (DGC)
Drugs
Diseases
GWAS		Coronary artery calcified atherosclerotic plaque (130 HU threshold) in type 2 diabetes ( 29221444) PR interval ( 32439900) Urate levels in overweight individuals ( 25811787)
Interacting Genes		16 interacting genes: ACTA1 APPL1 DMD DRP2 DTNBP1 GFI1B KCNJ12 SNTA1 SNTB1 SNTB2 SNTG1 SNTG2 STAT3 SYNC SYNM UTRN	3 interacting genes: DES DTNA ITSN1
Entrez ID		1837	81493
HPRD ID		03141	18134
Ensembl ID		ENSG00000134769	ENSG00000162520
Uniprot IDs		A0A7P0T9L1 A0A7P0TBH9 A0A7P0Z4D7 B7Z3X3 Q9Y4J8	Q9H7C4
PDB IDs		2E5R
Enriched GO Terms of Interacting Partners?		Dystrophin-associated Glycoprotein Complex Sarcolemma Syntrophin Complex Muscle Contraction Muscle System Process Actin Binding Vinculin Binding Structural Molecule Activity Cytoskeleton Regulation Of Sodium Ion Transmembrane Transport System Process Regulation Of Sodium Ion Transport Protein-containing Complex Filopodium Nitric-oxide Synthase Binding Neuromuscular Junction PDZ Domain Binding Plasma Membrane Costamere Structural Constituent Of Cytoskeleton Regulation Of Monoatomic Ion Transmembrane Transport Synapse Filopodium Membrane Myosin Binding Regulation Of Transport Positive Regulation Of Endocytosis Anchoring Junction Positive Regulation Of Cytokine Production Involved In Inflammatory Response Regulation Of Monoatomic Ion Transport Cardiac Muscle Cell Action Potential Structural Constituent Of Muscle Calmodulin Binding Regulation Of Heart Contraction Fast-twitch Skeletal Muscle Fiber Contraction Negative Regulation Of Fc-gamma Receptor Signaling Pathway Involved In Phagocytosis Cytoplasm Postsynaptic Membrane Regulation Of Blood Circulation Lateral Plasma Membrane Regulation Of Monoatomic Cation Transmembrane Transport Postsynaptic Density Glutamatergic Synapse Positive Regulation Of Growth Factor Dependent Skeletal Muscle Satellite Cell Proliferation Neurofilament Cytoskeleton Positive Regulation Of Macropinocytosis Positive Regulation Of Glutamate Neurotransmitter Secretion In Response To Membrane Depolarization Actin Cytoskeleton Signaling Striated Muscle Contraction Cell Communication	Intermediate Filament Cytoskeleton Sarcolemma Nuclear Envelope Muscle Contraction Clathrin-dependent Synaptic Vesicle Endocytosis Muscle System Process Positive Regulation Of Caveolin-mediated Endocytosis Cell Tip Supramolecular Fiber Fascia Adherens Cardiac Myofibril Postsynaptic Endocytic Zone Postsynaptic Actin Cytoskeleton Regulation Of Caveolin-mediated Endocytosis Positive Regulation Of Growth Hormone Secretion Regulation Of Modification Of Postsynaptic Actin Cytoskeleton Contractile Muscle Fiber Extrinsic Component Of Cytoplasmic Side Of Plasma Membrane Regulation Of Growth Hormone Secretion Regulation Of Modification Of Postsynaptic Structure Apical Dendrite Skeletal Muscle Organ Development Intracellular Vesicle Proline-rich Region Binding Regulation Of Modification Of Synaptic Structure Nuclear Envelope Organization Neuromuscular Synaptic Transmission Clathrin-dependent Endocytosis Positive Regulation Of Dendritic Spine Development Synaptic Vesicle Endocytosis Presynaptic Endocytosis Intercalated Disc Synapse Regulation Of Dendritic Spine Development
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