DTNA and SNTB2

Number of citations of the paper that reports this interaction (PubMedID 33961781)
97

Data Source:
BioGRID (affinity chromatography technology)
HPRD (in vivo)

		DTNA	SNTB2
Description		dystrobrevin alpha	syntrophin beta 2
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GO Annotations	Cellular Component	Nucleoplasm Cytoplasm Plasma Membrane Membrane Cell Junction Axon Extrinsic Component Of Cytoplasmic Side Of Plasma Membrane Protein-containing Complex Sarcolemma Cell Projection Intermediate Filament Cytoskeleton Synapse	Nucleoplasm Cytoplasm Golgi Apparatus Cytosol Cytoskeleton Microtubule Plasma Membrane Focal Adhesion Dystrophin-associated Glycoprotein Complex Membrane Transport Vesicle Membrane Cytoplasmic Vesicle Protein-containing Complex Centriolar Satellite Ciliary Basal Body Synapse Anchoring Junction
	Molecular Function	Protein Binding Zinc Ion Binding PDZ Domain Binding Metal Ion Binding	RNA Binding Actin Binding Structural Molecule Activity Protein Binding Calmodulin Binding
	Biological Process	Striated Muscle Contraction Signal Transduction Chemical Synaptic Transmission Neuromuscular Synaptic Transmission Synaptic Signaling
Pathways		Formation of the dystrophin-glycoprotein complex (DGC) Formation of the dystrophin-glycoprotein complex (DGC)	Formation of the dystrophin-glycoprotein complex (DGC) Formation of the dystrophin-glycoprotein complex (DGC)
Drugs
Diseases
GWAS		Coronary artery calcified atherosclerotic plaque (130 HU threshold) in type 2 diabetes ( 29221444) PR interval ( 32439900) Urate levels in overweight individuals ( 25811787)	Body mass index ( 26426971) Brain morphology (MOSTest) ( 32665545) Left-handedness ( 32989287) Logical memory (delayed recall) in normal cognition ( 29274321)
Interacting Genes		16 interacting genes: ACTA1 APPL1 DMD DRP2 DTNBP1 GFI1B KCNJ12 SNTA1 SNTB1 SNTB2 SNTG1 SNTG2 STAT3 SYNC SYNM UTRN	16 interacting genes: ABCA1 ADGRB1 ADRA1D DGKZ DMD DTNA ERBB4 KCNJ12 MAST1 MAST2 PTEN PTPRN SCN4A SCN5A UBC UTRN
Entrez ID		1837	6645
HPRD ID		03141	02491
Ensembl ID		ENSG00000134769	ENSG00000168807
Uniprot IDs		A0A7P0T9L1 A0A7P0TBH9 A0A7P0Z4D7 B7Z3X3 Q9Y4J8	Q13425
PDB IDs		2E5R	2VRF
Enriched GO Terms of Interacting Partners?		Dystrophin-associated Glycoprotein Complex Sarcolemma Syntrophin Complex Muscle Contraction Muscle System Process Actin Binding Vinculin Binding Structural Molecule Activity Cytoskeleton Regulation Of Sodium Ion Transmembrane Transport System Process Regulation Of Sodium Ion Transport Protein-containing Complex Filopodium Nitric-oxide Synthase Binding Neuromuscular Junction PDZ Domain Binding Plasma Membrane Costamere Structural Constituent Of Cytoskeleton Regulation Of Monoatomic Ion Transmembrane Transport Synapse Filopodium Membrane Myosin Binding Regulation Of Transport Positive Regulation Of Endocytosis Anchoring Junction Positive Regulation Of Cytokine Production Involved In Inflammatory Response Regulation Of Monoatomic Ion Transport Cardiac Muscle Cell Action Potential Structural Constituent Of Muscle Calmodulin Binding Regulation Of Heart Contraction Fast-twitch Skeletal Muscle Fiber Contraction Negative Regulation Of Fc-gamma Receptor Signaling Pathway Involved In Phagocytosis Cytoplasm Postsynaptic Membrane Regulation Of Blood Circulation Lateral Plasma Membrane Regulation Of Monoatomic Cation Transmembrane Transport Postsynaptic Density Glutamatergic Synapse Positive Regulation Of Growth Factor Dependent Skeletal Muscle Satellite Cell Proliferation Neurofilament Cytoskeleton Positive Regulation Of Macropinocytosis Positive Regulation Of Glutamate Neurotransmitter Secretion In Response To Membrane Depolarization Actin Cytoskeleton Signaling Striated Muscle Contraction Cell Communication	Plasma Membrane Muscle Contraction Muscle System Process Sarcolemma Regulation Of System Process Regulation Of Sodium Ion Transmembrane Transport Cardiac Muscle Cell Action Potential Membrane Cell Communication System Process Regulation Of Sodium Ion Transport PDZ Domain Binding Vinculin Binding Striated Muscle Contraction Nitric-oxide Synthase Binding Voltage-gated Sodium Channel Complex Regulation Of Multicellular Organismal Process Regulation Of Blood Circulation Dystrophin-associated Glycoprotein Complex Regulation Of Striated Muscle Contraction Voltage-gated Sodium Channel Activity Synapse Regulation Of Monoatomic Ion Transmembrane Transport Filopodium Membrane Action Potential Regulation Of Skeletal Muscle Contraction Regulation Of Biological Quality Cell-cell Signaling Muscle Organ Development Monoatomic Ion Channel Complex Signaling Synaptic Signaling Muscle Structure Development Regulation Of Transport Phagocytosis, Engulfment Phosphorylation Monoatomic Cation Channel Activity Regulation Of Monoatomic Ion Transport Sodium Channel Activity Regulation Of Muscle Contraction Cardiac Muscle Cell Action Potential Involved In Contraction Regulation Of Membrane Potential Cell Projection Cardiac Muscle Contraction Membrane Invagination Sphingolipid Floppase Activity Regulation Of Heart Contraction Positive Regulation Of Epithelial Cell Proliferation Establishment Of Planar Polarity Involved In Nephron Morphogenesis T-tubule
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