RCAN1 and SPARCL1

Number of citations of the paper that reports this interaction (PubMedID 35914814)
83

Data Source:
BioGRID (two hybrid)

		RCAN1	SPARCL1
Description		regulator of calcineurin 1	SPARC like 1
Image
GO Annotations	Cellular Component	Nucleus Cytoplasm	Extracellular Region Extracellular Space Endoplasmic Reticulum Lumen Glutamatergic Synapse
	Molecular Function	Nucleic Acid Binding Protein Phosphatase Inhibitor Activity Protein Binding Calcium-dependent Protein Serine/threonine Phosphatase Regulator Activity Identical Protein Binding	Calcium Ion Binding Protein Binding Collagen Binding Metal Ion Binding Extracellular Matrix Binding
	Biological Process	Response To Ischemia Response To Stress Response To Oxidative Stress Skeletal Muscle Tissue Development Short-term Memory Response To Mechanical Stimulus Calcium-mediated Signaling Locomotion Involved In Locomotory Behavior Calcineurin-NFAT Signaling Cascade Response To Estrogen Skeletal Muscle Fiber Development Negative Regulation Of Smooth Muscle Cell Differentiation Negative Regulation Of Calcineurin-NFAT Signaling Cascade	Signal Transduction Regulation Of Synapse Organization Synaptic Membrane Adhesion
Pathways			Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) Post-translational protein phosphorylation
Drugs		Dipyridamole
Diseases
GWAS		Cancer ( 29299148) Rheumatoid arthritis ( 23143596 24390342 30423114) Rheumatoid arthritis (ACPA-positive) ( 23143596 24532676)	Blood protein levels ( 30072576) Idiopathic dilated cardiomyopathy ( 29495422) Urate levels ( 31578528)
Interacting Genes		29 interacting genes: APP ATP5PO BTRC CBR3 CXXC5 DSCAM E2F3 GSK3B IL10RB ITSN1 KCNE1 MAP3K3 MAPK3 NEUROD2 PICK1 PPP3CA PPP3CB PPP3R1 PRDM4 PTPRD SF3A2 SON SOX10 SOX9 SPARCL1 USP22 UXT ZNF292 ZNF350	12 interacting genes: BTG3 DISC1 DSCR9 EGFR HUNK LCOR MYCBP2 PDGFRL PRNP RCAN1 SKIL TTC3
Entrez ID		1827	8404
HPRD ID		04226	06919
Ensembl ID		ENSG00000159200	ENSG00000152583
Uniprot IDs		B7Z1F0 E9PDJ2 P53805 Q6FGP2 Q6ZMM3 V9GYW9	B7ZB68 Q14515 Q8N4S1
PDB IDs		6UUQ	7KBU
Enriched GO Terms of Interacting Partners?		Regulation Of Calcium-mediated Signaling Modulation Of Chemical Synaptic Transmission Positive Regulation Of Calcium-mediated Signaling Regulation Of Transcription By RNA Polymerase II Glial Cell Development Negative Regulation Of Calcium Ion Import Across Plasma Membrane Calcineurin Complex Positive Regulation Of Cellular Component Organization Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription Positive Regulation Of RNA Metabolic Process Positive Regulation Of Transcription By RNA Polymerase II Regulation Of Calcineurin-NFAT Signaling Cascade Protein Serine/threonine Phosphatase Complex Regulation Of Calcineurin-mediated Signaling Positive Regulation Of Calcium Ion Import Across Plasma Membrane Regulation Of RNA Metabolic Process Positive Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Negative Regulation Of Calcium Ion Import Regulation Of Calcium Ion Import Across Plasma Membrane Glutamatergic Synapse Regulation Of Nucleobase-containing Compound Metabolic Process Positive Regulation Of Calcineurin-NFAT Signaling Cascade Calcineurin-NFAT Signaling Cascade Negative Regulation Of Cation Transmembrane Transport Negative Regulation Of Monoatomic Ion Transmembrane Transport Intracellular Signaling Cassette Cell Development Regulation Of Endocytosis Positive Regulation Of Calcium Ion Import Protein Dimerization Activity Calcineurin-mediated Signaling Regulation Of Cellular Component Organization Positive Regulation Of Cell Communication Positive Regulation Of Signaling Regulation Of Synaptic Plasticity Positive Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of Monoatomic Ion Transport Regulation Of Vesicle-mediated Transport Calmodulin-dependent Protein Phosphatase Activity Positive Regulation Of Metabolic Process Regulation Of Signal Transduction Positive Regulation Of Signal Transduction Regulation Of Cell Communication Regulation Of Signaling Positive Regulation Of Biosynthetic Process Negative Regulation Of Calcium Ion Transmembrane Transport Positive Regulation Of Cation Transmembrane Transport	Negative Regulation Of Calcineurin-NFAT Signaling Cascade Negative Regulation Of Calcium-mediated Signaling Regulation Of Calcineurin-mediated Signaling Regulation Of Calcineurin-NFAT Signaling Cascade Cerebral Cortex Cell Migration Cellular Response To Estradiol Stimulus Telencephalon Cell Migration Forebrain Cell Migration Skeletal Muscle Tissue Development Learning Or Memory Cognition Intracellular Signal Transduction Identical Protein Binding Positive Regulation Of Protein Localization To Plasma Membrane Positive Regulation Of Protein Localization To Cell Periphery Shc-EGFR Complex Response To Growth Factor Multivesicular Body, Internal Vesicle Lumen Platelet-derived Growth Factor Beta-receptor Activity Platelet-derived Growth Factor Receptor Activity Regulation Of Plasma Membrane Bounded Cell Projection Organization Type 8 Metabotropic Glutamate Receptor Binding Regulation Of Synapse Organization Regulation Of Cell Projection Organization Positive Regulation Of Axonogenesis Positive Regulation Of Protein Localization To Membrane Protein-containing Complex Binding Regulation Of Calcium-mediated Signaling Positive Regulation Of Protein Kinase C Signaling Epidermal Growth Factor Receptor Activity Platelet Activating Factor Receptor Activity Pyramidal Neuron Migration To Cerebral Cortex Central Region Of Growth Cone
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