DOCK1 and STX16

		DOCK1	STX16
Description		dedicator of cytokinesis 1	syntaxin 16
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GO Annotations	Cellular Component	Cytoplasm Cytosol Plasma Membrane Membrane Guanyl-nucleotide Exchange Factor Complex Postsynapse Glutamatergic Synapse	Golgi Membrane Cytoplasm Endoplasmic Reticulum Golgi Apparatus Trans-Golgi Network Cytosol Focal Adhesion Endomembrane System Membrane Synaptic Vesicle Membrane SNARE Complex Golgi Cisterna Trans-Golgi Network Membrane Intracellular Membrane-bounded Organelle Perinuclear Region Of Cytoplasm
	Molecular Function	Guanyl-nucleotide Exchange Factor Activity GTPase Activator Activity Protein Binding SH3 Domain Binding Small GTPase Binding	SNARE Binding SNAP Receptor Activity Protein Binding Syntaxin Binding
	Biological Process	Phagocytosis Phagocytosis, Engulfment Apoptotic Process Signal Transduction Integrin-mediated Signaling Pathway Small GTPase-mediated Signal Transduction Myoblast Fusion Positive Regulation Of Epithelial Cell Migration Cell Migration Regulation Of Postsynapse Assembly Positive Regulation Of Substrate Adhesion-dependent Cell Spreading	Intracellular Protein Transport Vesicle Fusion Protein Transport Vesicle-mediated Transport Endocytic Recycling Retrograde Transport, Endosome To Golgi Vesicle Docking
Pathways		Regulation of actin dynamics for phagocytic cup formation DCC mediated attractive signaling DCC mediated attractive signaling VEGFA-VEGFR2 Pathway PTK6 Regulates RHO GTPases, RAS GTPase and MAP kinases RAC1 GTPase cycle RAC2 GTPase cycle RHOG GTPase cycle FCGR3A-mediated phagocytosis Factors involved in megakaryocyte development and platelet production	Intra-Golgi traffic Retrograde transport at the Trans-Golgi-Network
Drugs
Diseases			Pseudohypoparathyroidism
GWAS		Airway wall thickness ( 25517131) Apolipoprotein Levels ( 23031429) Body mass index ( 25673413) Body mass index (change over time) in gastrointestinal cancer ( 28044437) Body mass index (change over time) in gastrointestinal cancer or chronic obstructive pulmonary disease ( 28044437) BRCA1/2-negative high-risk breast cancer ( 30323354) Chronotype ( 30696823) Gut microbiota (bacterial taxa, hurdle binary method) ( 32572223) Homeostasis model assessment of insulin resistance in less-fat diet ( 30327367) Response to cytidine analogues (gemcitabine) ( 24483146) Response to TNF inhibitor in rheumatoid arthritis (change in disease activity score) ( 30166627) Response to TNF inhibitor in rheumatoid arthritis (change in tender 28-joint count) ( 30166627) Social communication problems ( 24564958) Weight ( 28552196)	Cardiovascular risk factors (age interaction) ( 20838585) Hemoglobin ( 32888494)
Interacting Genes		18 interacting genes: ADAM12 BCAR1 C10orf90 CLRN3 CRK CYTH2 ELMO1 ELMO2 MMP21 NCK2 PRKACA PSAT1 RAC1 RHOG STX16 TAMALIN TLK2 WASF2	13 interacting genes: DOCK1 MEOX2 NAPB PTPN12 RHOU STX1A STX2 STX4 STX6 VAMP3 VAMP4 VPS45 VTI1A
Entrez ID		1793	8675
HPRD ID		03240	04718
Ensembl ID		ENSG00000150760	ENSG00000124222
Uniprot IDs		A0A096LNH6 A0A2X0U2H5 B2RUU3 Q14185	B4DJX9 O14662
PDB IDs		3L4C	8QQF
Enriched GO Terms of Interacting Partners?		SH3 Domain Binding Rac Protein Signal Transduction Actin Filament Organization Actin Cytoskeleton Organization Cell Chemotaxis Actin Filament-based Process Cell Motility Regulation Of Cellular Component Organization Supramolecular Fiber Organization Lamellipodium Assembly Regulation Of Postsynapse Assembly Lamellipodium Organization Chemotaxis Cell Migration Regulation Of Actin Cytoskeleton Organization Locomotion Positive Regulation Of Skeletal Muscle Acetylcholine-gated Channel Clustering Hepatocyte Growth Factor Receptor Signaling Pathway Regulation Of Actin Filament-based Process Regulation Of Skeletal Muscle Acetylcholine-gated Channel Clustering Receptor Tyrosine Kinase Binding Positive Regulation Of Receptor Clustering Endocytosis Postsynapse Positive Regulation Of Protein Localization To Membrane Response To Hepatocyte Growth Factor Regulation Of Cell Junction Assembly Small GTPase-mediated Signal Transduction Regulation Of Receptor Clustering Regulation Of Cytoskeleton Organization Actin Cytoskeleton Glutamatergic Synapse Regulation Of Bicellular Tight Junction Assembly Protein Kinase A Regulatory Subunit Binding Cytoskeleton Organization Positive Regulation Of Lamellipodium Assembly Import Into Cell Regulation Of Cell Shape Regulation Of Postsynapse Organization Regulation Of Ruffle Assembly Cytosol Neuron Migration Phagocytosis, Engulfment Signaling Receptor Complex Adaptor Activity Positive Regulation Of Lamellipodium Organization Establishment Or Maintenance Of Cell Polarity Regulation Of Synapse Assembly Regulation Of Protein Localization To Membrane Regulation Of Lamellipodium Assembly Positive Regulation Of Supramolecular Fiber Organization	SNARE Complex SNAP Receptor Activity Organelle Fusion Vesicle-mediated Transport Vesicle Fusion Organelle Membrane Fusion SNARE Complex Assembly Vesicle Docking SNARE Binding Membrane Fusion Vesicle Organization Intracellular Protein Transport Organelle Localization By Membrane Tethering Membrane Docking Protein Transport Intracellular Transport Endomembrane System Establishment Of Protein Localization Membrane Organization Cellular Localization Establishment Of Localization In Cell Phagocytic Vesicle Intracellular Protein Localization Trans-Golgi Network Membrane Synaptic Vesicle To Endosome Fusion Vesicle-mediated Transport To The Plasma Membrane Synaptobrevin 2-SNAP-25-syntaxin-1a Complex Cornified Envelope Assembly Endosome Exocytosis Organelle Localization Cellular Response To Type II Interferon Endocytic Recycling Clathrin-coated Vesicle Regulation Of Synaptic Vesicle Priming Localization Within Membrane Endosomal Transport Glutamatergic Synapse Golgi Vesicle Transport Retrograde Transport, Endosome To Golgi Response To Type II Interferon Post-Golgi Vesicle-mediated Transport Golgi Membrane Bounding Membrane Of Organelle Cytosolic Transport Synaptic Vesicle Organelle Organization Secretion By Cell Presynaptic Active Zone Membrane Calcium-ion Regulated Exocytosis
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